Neutrophil-to-lymphocyte count ratio is associated with perforated appendicitis in elderly patients of emergency department

Jung, Si Kyung; Rhee, Dong Yoon; Lee, Woon Jeong; Woo, Seon Hee; Seol, Seung Hwan; Kim, Dae–Hee; Choi, Seung Pill

doi:10.1007/s40520-016-0584-8

Cited by 34 publications

(35 citation statements)

References 25 publications

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“…AUC value of NLR was 0.755 (95% CI, 0.660-0.834), cut-off value was 5.6, sensitivity was 78.0%, and specificity was 65.9%. [16] In the current study, NLR value in group with appendicitis was statistically significantly higher than in control group, which was in accordance with results seen in the literature.…”

Section: Discussionsupporting

confidence: 93%

Ischemia modified albumin and other inflammatory markers in the diagnosis of appendicitis in children

Nazik

Avcı²,

Kiraz³

2016

Ulus Travma Acil Cerrahi Derg

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Section: Discussionsupporting

confidence: 93%

Ischemia modified albumin and other inflammatory markers in the diagnosis of appendicitis in children

Nazik

Avcı²,

Kiraz³

2016

Ulus Travma Acil Cerrahi Derg

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“…Thus, the ratio of these 2 subgroups (NLR) is used as a parameter of inflammation. [7][8][9][10][11][12][13] In a study designed by Kahramanca et al [9] it was determined that NLR was a useful parameter for diagnosing AA and discriminating between SA and CA. In a study involving 3392 cases, Sevinç et al [12] found that the WBC count was not a significant parameter in CA diagnosis, though it was significant in diagnosing AA.…”

Section: Discussionmentioning

confidence: 99%

A New And Early Marker In Diagnosis Of Acute Complicated Appendicitis: Immature Granulocyte

Ünal

2018

Ulus Travma Acil Cerrahi Derg

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BACKGROUND:The aim of this study was to investigate the effectiveness of the immature granulocyte (IG) count (IGC) and percentage (IG%) in both diagnosing acute appendicitis (AA) and discriminating between simple appendicitis (SA) and complicated appendicitis (CA). METHODS:This study was carried out using the data of 438 adult patients who underwent an appendectomy. Demographic details, the preoperative white blood cell (WBC) count, neutrophil/lymphocyte ratio (NLR), IGC and IG%, operation findings, and pathology results were assessed retrospectively. The patients were grouped as AA and normal appendix (NA) according to the pathology reports, and the AA cases were subdivided into SA and CA groups according to the intraoperative findings. RESULTS: WBC, NLR, IGC, and IG% were significant parameters in the diagnosis of AA. The area under the receiver operating characteristic curve (AUROC: 0.795), sensitivity (55.5%) and specificity (96.1%) values of IGC were higher than the other parameters. All of the parameters were also significant for a CA diagnosis; however, the value of IG% in a CA diagnosis was stronger than the other parameters (IG% AUROC: 0.979, sensitivity: 94.4%, specificity: 97.9%). CONCLUSION:The IG value is a fast, easily available, and reliable parameter in both diagnosing AA and discriminating between SA and CA.

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“…The complete blood count (CBC) is one of the most commonly used laboratory tests for the diagnosis of AA. Many studies have focused on the role of white blood cell (WBC), neutrophil-to-lymphocyte ratio (NLR), platelet distribution width (PDW), mean platelet volume (MPV), red cell distribution width (RDW), platelet count (PLT), lymphocyte (L), neutrophil (N), C-reactive protein (CRP), and Lymphocyte-C-reactive protein ratio (LCR) values in the diagnosis of AA [4,8,[16][17][18]. We aimed to investigate the diagnostic efficacy of CBC parameters, CRP, and LCR in AA diagnosis and their relationship with appendix diameter.…”

Section: Introductionmentioning

confidence: 99%

The Correlation between Complete Blood Count Parameters and Appendix Diameter for the Diagnosis of Acute Appendicitis

Daldal

Dagmura

2020

Healthcare

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Acute appendicitis is one of the most common causes of acute abdominal diseases seen between the ages of 10 and 19, mostly seen in males. The lifetime risk of developing acute appendicitis is 8.6% for males and 6.7% for females. We aimed to investigate the efficacy of the complete blood count parameters, C-reactive protein, and Lymphocyte-C-reactive Protein Ratio laboratory tests in the diagnosis of acute appendicitis, as well as their relationship with appendix diameter. We retrospectively examined all patients who underwent appendectomy between 1 January 2012 and 30 June 2019 in the General Surgery Clinic of Gaziosmanpasa University Faculty of Medicine. Laboratory tests, imaging findings, age, and gender were recorded. Lymphoid hyperplasia is considered as normal appendix—in other words, as negative appendicitis. The distribution of Lymphoid hyperplasia and appendicitis rates were statistically different in the groups formed according to appendix diameter (≤6 and >6 mm) (p < 0.001). We found a significant correlation between appendix diameter and WBC (White blood count), Lymphocyte, Neutrophil, RDW(Red blood cell distribution width), NLR(Neutrophil to lymphocyte ratio), and PLT/L (Platelet to lymphocyte ratio), MPV (Mean platelet volume) and RDW were significantly different in patients with an appendix diameter of ≤6 mm (p = 0.007, p = 0.006, respectively). WBC, Neutrophil, PDW, and NLR values were significantly different between appendicitis and hyperplasia groups in patients with an appendix diameter of >6 mm. The sensitivity of the NLR score (cutoff = 2.6057) in the diagnosis of appendicitis was 86.1% and selectivity was 50% in these patients. Complete blood count parameters evaluation with the clinical findings revealed that NLR is an important parameter that may help the diagnosis of acute appendicitis with an appendix diameter of >6 mm. In patients whose pathological results indicated acute appendicitis but who had a diameter of ≤6 mm, we found an elevated MPV and low RDW values.

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Neutrophil-to-lymphocyte count ratio is associated with perforated appendicitis in elderly patients of emergency department

Abstract: We suggest that the initial NLR in the elderly patient is the most powerful predictive factor for the diagnosis of AA perforation in the ED.

Cited by 34 publications

References 25 publications

Ischemia modified albumin and other inflammatory markers in the diagnosis of appendicitis in children

Ischemia modified albumin and other inflammatory markers in the diagnosis of appendicitis in children

A New And Early Marker In Diagnosis Of Acute Complicated Appendicitis: Immature Granulocyte

The Correlation between Complete Blood Count Parameters and Appendix Diameter for the Diagnosis of Acute Appendicitis

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