Ischemia modified albumin and other inflammatory markers in the diagnosis of appendicitis in children

Nazik, Selçuk; Avcı, Veli; Kiraz, Zeynep Küskü

doi:10.5505/tjtes.2016.11823

Cited by 26 publications

(36 citation statements)

References 12 publications

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“…The sensitivity of the WCC in acute appendicitis ranges from 65-89.4% with a specificity of 55-80% in studies done in HICs; 3,[22][23][24][25] in comparison, our results show a lower sensitivity and specificity of 69.6% and 43.1%, respectively. This may perhaps be attributed to the higher incidence of other infections in our populations such as tuberculosis and worm infestation.…”

Section: Discussionmentioning

confidence: 52%

Correlation of white cell count and CRP in acute appendicitis in paediatric patients

Withers¹,

Grieve²,

Loveland³

2019

S. Afr. j. surg.

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Background: Ten per cent of children who present with abdominal pain at an emergency department are diagnosed with acute appendicitis. The diagnosis of which relies on clinical acumen, but addition of tests such as measurement of the white cell count (WCC) and C-reactive protein (CRP) are needed to decrease the morbidity associated with inappropriate surgical management. This study evaluates the sensitivity, specificity and accuracy of the WCC and CRP separately and when used in combination and evaluates whether an increased WCC and CRP are associated with complicated appendicitis. Methods: A retrospective record review of all paediatric patients who underwent appendicectomy between June 2010 and December 2016 was conducted. Demographic data, the WCC, CRP and histology results were reviewed. Results: 763 records were reviewed. The sensitivity and specificity of the WCC were 69.6% and 43.1% respectively and of the CRP were 95.4% and 24.5% respectively. The sensitivity was higher when both the CRP and WCC were elevated (97.47%). A normal WCC and CRP had a specificity of 98%, with an odds ratio of 8.69 of a patient not having appendicitis. There was a borderline significance between the WCC and the presence of acute appendicitis (p = 0.0494). The CRP was significant in patient with acute appendicitis (p < 0.0001). The WCC and CRP between uninflamed appendix specimens, uncomplicated appendicitis and complicated appendicitis was significant. Conclusion: Both increasing CRP and WCC correlates with an increased likelihood of the presence of complicated appendicitis. The chance of a patient having appendicitis with both normal WCC and CRP is low.

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Section: Discussionmentioning

confidence: 52%

Correlation of white cell count and CRP in acute appendicitis in paediatric patients

Withers¹,

Grieve²,

Loveland³

2019

S. Afr. j. surg.

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“…In their study, Dumlu et al (29) also observed increased IMA levels in the AG than in the CG. In a study conducted in children, Nazik et al (30) observed that IMA levels were elevated in AA. Kılıç et al (31) suggested that IMA levels in adult AA patients are significantly elevated and can be used as an indicator of appendicitis severit.…”

Section: The Demographic Results Of Groupsmentioning

confidence: 98%

Tiyol / Disülfit dengesinin değerlendirilmesi çocuklarda apandisitin ayırıcı tanısında yardımcı olabilir mi?

Demir¹,

Günal²,

Özmen³

et al. 2020

Turkish Journal of Pediatric Disease

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Objective: We aimed to investigate the potential of assessing thiol/disulfide homeostasis as novel oxidative stress markers to improve the challenging diagnosis of acute appendicitis in children. Material and Methods: A total of 60 pediatric patients (0-18 years) were enrolled in the study, 30 of which were in the control group and 30 in the acute appendicitis group. Native thiol, total thiol, dynamic disulfide, dynamic thiol, ischemia modified albümin, albumin, White blood cell, hemoglobin, hematocrit, and platelet counts of both groups were measured. The results of both groups were compared using the SPSS (Statistical Package for Social Sciences) version 17 (Chicago, USA) program. For all variables, p <0.05 was considered significant. Results: Total thiol (p<0.001), native thiol (p<0.001), and albümin (p<0.001) levels were significantly decreased while dynamic disulfide, dynamic thiol (p=0.003), and ischemia modified albümin (p<0.001) levels those indicating oxidant side were increased in acute appendicitis group compared to control. White blood cell counts in acute appendicitis group were higher (p<0.001), and platelet counts were lower (p=0.03) than the control group. Conclusion: In the differential diagnosis of acute appendicitis, especially in case that are difficult to diagnose, besides a physical examination, imaging, and current laboratory tests, quantification of thiol/disulfide homeostasis may be helpful in diagnosing. In addition, evaluating albumin and IMA levels may increase the specificity of the test. This test can be more helpful in cases diagnosis is difficult such as children small in their ages and mental retardation.

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“…In a recent study, NLR, and PLR were evaluated in patients treated for familial Mediterranean fever 19 ; PLR was deemed increased in patients with the condition compared with the control group. In another study by Nazik 20 , use of NLR, PLR, IMA, and ESR values may be helpful in the diagnosis of appendicitis. In our study, PLR was increased with in ammation and was higher in the perforated appendectomy group (237.51 ± 149.98).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Reliable Biomarkers for the Diagnosis of Perforated Acute Appendicitis: A Retrospective case control study

Zhou

Han

et al. 2020

Preprint

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Background To investigate the relationship among neutrophil to lymphocyte ratio (NLR),platelet to lymphocyte ratio (PLR) of patients with perforated acute appendicitis and its clinical significance༎ Methods The present study selected 243 patients who underwent appendectomy presented with acute appendicitis from January 2013 and December 2015༎All patients were confirmed by pathology༎AA patients were divided into Perforated acute appendicitis(PAA)group and Non-perforated acute appendicitis༈NPAA༉ group༎The routine blood test results were collected pre-operation and calculated the NLR and PLR༎To analyze the relationship among the NLR,PLR, Age, Gender, WBC count, Operation approach in PAA group and NPAA group. Results The NLR and PLR of PAA group were significantly higher than that of the NPAA group (P < 0.0001 and P = 0.039);Cut-off value NLR (≥ 8.96) and PLR (≥ 173.03) of were PAA group were significantly higher than that of the NPAA group (P < 0.0001 and P = 0.012). Multiple logistic regression analysis identified NLR as independent variables. Conclusions We suggest that the preoperative NLR and PLR are useful parameters to differentiate among PAA and NPAA.

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Ischemia modified albumin and other inflammatory markers in the diagnosis of appendicitis in children

Cited by 26 publications

References 12 publications

Correlation of white cell count and CRP in acute appendicitis in paediatric patients

Correlation of white cell count and CRP in acute appendicitis in paediatric patients

Tiyol / Disülfit dengesinin değerlendirilmesi çocuklarda apandisitin ayırıcı tanısında yardımcı olabilir mi?

Evaluation of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Reliable Biomarkers for the Diagnosis of Perforated Acute Appendicitis: A Retrospective case control study

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