Effects of high di(2-ethylhexyl) phthalate (DEHP) exposure due to tainted food intake on pre-pubertal growth characteristics in a Taiwanese population

Tsai, Yu-Chen; Lin, Ching-Ling; Hou, Jia‐Woei; Huang, Po-Chin; Lee, Meng-Chih; Chen, Bai-Hsiun; Wu, Ming Tsang; Chen, Chu-Chih; Wang, Shu Li; Lee, Ching-Chang; Hsiung, Chao A.; Chen, Mei-Lien

doi:10.1016/j.envres.2016.05.005

Cited by 28 publications

(11 citation statements)

References 55 publications

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“…Wu et al (2013), in a cohort of Tanner Stage I Taiwanese children ( n = 60) between the ages of two to eight, found that children exposed to DEHP and DiNP tainted foodstuffs had significantly reduced TSH levels compared with the unexposed children. In a follow-up study of these children exposed to tainted food intake, Tsai et al (2016) observed that daily DEHP intake was not associated with thyroid hormone levels among children between 6 and 10.5 years of age.…”

Section: Discussionmentioning

confidence: 91%

Phthalates and thyroid function in preschool age children: Sex specific associations

Morgenstern

Whyatt

Insel

et al. 2017

Environment International

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Background Research relating either prenatal or concurrent measures of phthalate exposure to thyroid function in preschool children is inconclusive. Methods In a study of inner-city mothers and their children, metabolites of di-n-butyl phthalate, butylbenzyl phthalate, di-isobutyl phthalate, di(2-ethylhexyl) phthalate, and diethyl phthalate were measured in a spot urine sample collected from women in late pregnancy and from their children at age 3 years. We measured children's serum free thyroxine (FT4) and thyroid stimulating hormone (TSH) at age 3. Linear regression models were used to investigate the associations between phthalate metabolites, measured in maternal urine during late pregnancy and measured in child urine at age 3 and thyroid function measured at age 3. Results Mean concentrations (ranges) were 1.42 ng/dL (1.02 - 2.24) for FT4, and 2.62 ulU/mL (0.61 – 11.67) for TSH. In the children at age 3, among girls, FT4 decreased with increasing loge mono-n-butyl phthalate [estimated b = -0.06; 95% CI: (-0.09, -0.02)], loge mono-isobutyl phthalate [b = -0.05; 95% CI: (-0.09, -0.01)], loge monoethyl phthalate [b = -0.04; 95% CI: (-0.07, -0.01)], and loge mono(2-ethyl-5-hydroxyhexyl) phthalate [b = -0.04; 95% CI: (-0.07, -0.003)] and loge. mono(2-ethyl-5-oxy-hexyl) phthalate [b = -0.04; 95% CI: (-0.07, -0.004)] In contrast, among boys, we observed no associations between FT4 and child phthalate metabolites at age 3. On the other hand, in late gestation, FT4 increased with increasing loge mono-(2-ethylhexyl) phthalate [estimated b = 0.04; 95% CI: (0.02, 0.06)] and no sex difference was observed. We found no associations between phthalate biomarkers measured in either the child or prenatal samples and TSH at age 3. Conclusions The data show inverse and sex specific associations between specific phthalate metabolites measured in children at age 3 and thyroid function in preschool children. These results may provide evidence for the hypothesis that reductions in thyroid hormones mediate associations between early life phthalate exposure and child cognitive outcomes.

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Section: Discussionmentioning

confidence: 91%

Phthalates and thyroid function in preschool age children: Sex specific associations

Morgenstern

Whyatt

Insel

et al. 2017

Environment International

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“…In Taiwan, there is no suggested TDI value for DiBP, even though this phthalate was reported41 to reduce fetal testosterone production with a potency similar to that of both DnBP and DEHP, which suggests that it is appropriate to use the EFSA TDI value for DnBP to estimate exposure to DnBP and DiBP simultaneously. For vulnerable groups—especially children—the growing evidence indicated that growth and development of the reproductive and endocrine systems could be disrupted42434445. In addition, results from the recent toxicological phthalates studies have indicated a consideration of each TDI for each individual phthalate would be inappropriate for the overall tolerable phthalate intake383940.…”

Section: Discussionmentioning

confidence: 99%

Estimated Daily Intake and Cumulative Risk Assessment of Phthalates in the General Taiwanese after the 2011 DEHP Food Scandal

Chang

Lee

Pan

et al. 2017

Sci Rep

Self Cite

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A food scandal occurred in Taiwan in 2011 because the DEHP (di-2-ethylhexyl phthalate) had been intentionally used in food products. We assessed the daily intakes (DIs) and cumulative risk of phthalates in Taiwan’s general population after the scandal. The DIs of 6 phthalates, including di-n-butyl phthalate (DnBP), di-iso-butyl phthalate (DiBP), and DEHP, were evaluated using urinary phthalate metabolites. Hazard quotients of phthalates classified as affecting the reproductive (HQrep) and hepatic (HQhep) systems were assessed using cumulative approach. The creatinine-based model showed that the highest DI values in children 7-to 12- years-old were for DEHP (males: median: 4.79 μg/kg bw/d; females: median: 2.62 μg/kg bw/d). The 95th percentile (P95) of HQrep values were all >1 in the 7- to 12-year-old and 18- to 40-year-old male groups. The P95 of HQhep values were all >1 in the 7- to 18- year-old male groups. Most of the HQrep was attributable to the HQs of DnBP and DiBP (53.9–84.7%), and DEHP contributed most to HQhep (83.1–98.6%), which reveals that DnBP, DiBP and DEHP were the main risk of phthalate exposure for Taiwanese. Taiwan’s general population is widely exposed to DnBP, DiBP and DEHP, especially for young children.

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“…: intraperitoneal; JZ: junctional zone of placenta; LAB: labyrinth layer of placenta; LOI: loss of imprinting; MBS: maternal blood space; PND: postnatal day; s.c.: subcutaneous; T: testosterone; TA: total area; TCDD: 2,3,7,8-tetrachlorodibenzodioxin; TGC: trophoblast giant cell Note: Environmental Protection Agency’s established reference doses (if determined): BPA: 50 μg/kg bw/d (47); DEHP: 20 μg/kg bw/d (80) …”

Section: Tablementioning

confidence: 99%

“… Note: Environmental Protection Agency’s established reference doses (if determined): BPA: 50 μg/kg bw/d (47); DEHP: 20 μg/kg bw/d (80) …”

Section: Tablementioning

confidence: 99%

Morphologic and molecular changes in the placenta: what we can learn from environmental exposures

Vrooman

Xin

Bartolomei

2016

Fertility and Sterility

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In mammals, the extraembryonic tissues, which include the placenta, are crucial for embryonic development and growth. Because the placenta is no longer needed for postnatal life, however, it has been relatively understudied as a tissue of interest in biomedical research. Recently, increased efforts have been placed on understanding the placenta and how it may play a key role in human health and disease. In this review, we discuss two very different types of environmental exposures--assisted reproductive technologies and in utero exposure to endocrine disrupting chemicals. We summarize the current literature on their effects on placental development in both rodent and human, and comment on the potential use of placental biomarkers as predictors of offspring health outcomes.

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Effects of high di(2-ethylhexyl) phthalate (DEHP) exposure due to tainted food intake on pre-pubertal growth characteristics in a Taiwanese population

Cited by 28 publications

References 55 publications

Phthalates and thyroid function in preschool age children: Sex specific associations

Phthalates and thyroid function in preschool age children: Sex specific associations

Estimated Daily Intake and Cumulative Risk Assessment of Phthalates in the General Taiwanese after the 2011 DEHP Food Scandal

Morphologic and molecular changes in the placenta: what we can learn from environmental exposures

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