Morphologic and molecular changes in the placenta: what we can learn from environmental exposures

Vrooman, Lisa A.; Xin, Frances; Bartolomei, Marisa S.

doi:10.1016/j.fertnstert.2016.08.016

Cited by 33 publications

(20 citation statements)

References 88 publications

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“…In this context, researchers are studying the possible effects that EDCs can cause at the placental level [20], and some of the most important knowledge that emerged so far is summarized below.…”

Section: From Environment To Pregnant Mothermentioning

confidence: 99%

Endocrine-Disrupting Chemicals in Human Fetal Growth

Street

Bernasconi

2020

IJMS

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Fetal growth is regulated by a complex interaction of maternal, placental, and fetal factors. The effects and outcomes that chemicals, widely distributed in the environment, may have on the health status of both the mother and the fetus are not yet well defined. Mainly mixtures of chemical substances are found in the mothers and placenta. Exposure to endocrine-disrupting chemicals (EDCs) can be associated with fetal growth retardation, thyroid dysfunction, and neurological disorders. EDCs mostly interfere with insulin, glucocorticoid, estrogenic, and thyroid pathways, with subsequent effects on normal endocrine and metabolic functions, which cause changes in the epigenome and state of inflammation with life-long effects and consequences. International scientific societies recommend the implementation of research and of all possible preventive measures. This review briefly summarizes all these aspects.

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Section: From Environment To Pregnant Mothermentioning

confidence: 99%

Endocrine-Disrupting Chemicals in Human Fetal Growth

Street

Bernasconi

2020

IJMS

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“…Over the last 10 years since the first PPTox conference, the DOHaD field has expanded significantly including new windows of exposure, new environmental chemicals, a considerable growth in the transgenerational epigenetic inheritance and obesogen areas as well as an expanded focus on the placenta, liver reproduction, immune and neurodevelopment/neurobehaviour …”

Section: Summary and Future Directionsmentioning

confidence: 99%

The developmental basis of disease: Update on environmental exposures and animal models

Heindel

2018

Basic Clin Pharma Tox

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At the Prenatal Programming and Toxicity (PPTox) Conference I in 2008, I presented an overview of the developmental origins of health and disease field focusing on environmental chemical exposures and disease outcomes. At that time, I noted that the field was getting off the ground with a focus on developmental exposure to a small number of endocrine disrupting chemicals (EDCs) and disease outcomes across the lifespan in animal models. In this update, I note that the DOHaD field has changed significantly over the last decade. There are new windows of susceptibility including preconception, prepuberty, a focus on the mother and not just the offspring, and a significant focus on the new field of epigenetic transgenerational inheritance. New disease focus areas have sprung up including obesity, type 2 diabetes and fatty liver disease, all with a connection to developmental exposures to EDCs. There is also a focus on the study of new EDCs, molecular mechanisms, the development of new biomarkers of exposure and disease outcomes and studies focusing on intervention and prevention studies.

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“…The association between incinerators and preterm birth, however, demonstrates that dioxin teratogenicity does not account for all adverse reproductive outcomes associated with waste incinerators. Other possible links include effects of dioxins on placental development and function 75 as well as endocrine signalling 76,77 …”

Section: Resultsmentioning

confidence: 99%

The health impacts of waste incineration: a systematic review

Tait

Brew

Che

et al. 2020

Australian and New Zealand Journal of Public Health

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Introduction: Waste incineration is increasingly used to reduce waste volume and produce electricity. Several incinerators have recently been proposed in Australia and community groups are concerned about health impacts. An overview of the evidence on health effects has been needed. Method:A systematic review of English language literature for waste incinerators and health using PRISMA methodology. Results:A range of adverse health effects were identified, including significant associations with some neoplasia, congenital anomalies, infant deaths and miscarriage, but not for other diseases. Ingestion was the dominant exposure pathway for the public. Newer incinerator technologies may reduce exposure.Discussion: Despite these findings, diverse chemicals, poor study methodologies and inconsistent reporting of incinerator technology specifications precludes firmer conclusions about safety. Conclusion:Older incinerator technology and infrequent maintenance schedules have been strongly linked with adverse health effects. More recent incinerators have fewer reported ill effects, perhaps because of inadequate time for adverse effects to emerge. A precautionary approach is required. Waste minimisation is essential.Implications for public health: Public health practitioners can offer clearer advice about adverse health effects from incinerators. We suggest improved research design and methods to make future studies more robust and comparable. We offer ideas for better policy and regulation.

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Morphologic and molecular changes in the placenta: what we can learn from environmental exposures

Cited by 33 publications

References 88 publications

Endocrine-Disrupting Chemicals in Human Fetal Growth

Endocrine-Disrupting Chemicals in Human Fetal Growth

The developmental basis of disease: Update on environmental exposures and animal models

The health impacts of waste incineration: a systematic review

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