Prognostic factors in infective endocarditis in general hospitals in the Netherlands

Abstract

IntroductionDespite advances in treatment, infective endocarditis (IE) still ranks amongst the most lethal infectious diseases. We sought to determine prognostic factors in general hospitals in the Netherlands as research in this setting is scarce.ResultsBetween 2004 and 2011, we identified 216 cases of IE, 30.1 % of which were prosthetic valve IE. This leads to an annual incidence of IE of 5.7 new cases per 100,000 persons per year. Women were less likely to undergo surgical intervention (OR = 1.96, 95 % CI 1.06–3.61, p = 0.031). Also, ageing was an independent prognostic factor for not receiving surgery in a multivariate analysis (annual OR = 1.04, 95 % CI 1.02–1.06, p < 0.001). Female sex was a prognostic factor for mortality (OR = 2.35, 95 % CI 1.29–4.28, p = 0.005). Age was also an independent prognostic factor for mortality (OR = 1.05, 95% CI 1.03–1.08, p < 0.001). Conservative treatment was a prognostic factor for mortality (OR = 3.39, 95 % CI 1.80–6.38, p < 0.001) whereas surgical intervention was an independent prognostic factor for adverse events (OR = 3.03, 95% CI 1.64–5.55, p < 0.001). Staphylococcus aureus was an independent prognostic factor for adverse events (OR = 2.05, 95 % CI 1.10–3.84, p = 0.024) but not for mortality.ConclusionThis study shows that endocarditis in general hospitals has a high rate of morbidity and mortality. Even when treated, it ranks as one of the most lethal infectious diseases in the Netherlands, especially in women and the elderly.

Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016

“…Compared to the literature published from China on IE, the rate approached to other studies in our region [14][15][16]. But it was significantly lower than that reported by other studies from developed countries with 74-100% [26,27]. However, according to the 2015 European Association of Cardiology guidelines on IE, for TTE positive patients, TEE should be performed to exclude perivalvular complications [1].…”

Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016

“…Compared to the literature published from China on IE, the rate approached to other studies in our region [14][15][16]. But it was signi cantly lower than that reported by other studies from developed countries with 74%-100% [26,27].However, according to the 2015 European Association of Cardiology guidelines on IE , for TTE positive patients, TEE should be performed to exclude perivalvular complications [1]. The low utilization rate of TEE could directly resulted in the low detection rate of perivalvular complications such as valvular perforation and perivalvular abscess.…”

Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016

“…Based on a review of the literature published from China on IE, the rate was similarly but it approached to other studies in our region [13,18,19]. But this rate was significantly lower than that reported by other studies from developed countries with 74%-100% [20,21].However, according to the 2015 European Association of Cardiology guidelines on IE, for TTE positive patients, TEE should be performed to exclude perivalvular complications[1]. The low utilization rate of TEE could directly resulted in the low detection rate of perivalvular complications such as valvular perforation and perivalvular abscess in our study.…”