2016
DOI: 10.1016/j.carbpol.2016.04.056
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Effect of starch on the mechanical and in vitro properties of collagen-hydroxyapatite sponges for applications in dentistry

Abstract: This study sought to improve the mechanical and blood-absorbing properties of collagen sponges, while keeping them compressible, by incorporating blended hydroxyapatite (HA)-starch. Results were compared with CollaPlug(®) (pure collagen). The elastic modulus increased from 1.5±0.2kPa for CollaPlug(®) to 49±8kPa for sponges with composition 1:4:10 (collagen:HA:starch, by weight). The modified microstructure and surface area provided by the starch granules on the sponges improved cell viability. Sponges with com… Show more

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Cited by 25 publications
(16 citation statements)
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“…Collagen has been clinically applied as a promising biomaterial to regenerate bone tissue due to the fact of its biodegradation, low antigenicity, and cytocompatibility [168,169,170]. Pure collagen are relatively soft (elastic modulus: 14.6 ± 2.8 kPa) and cannot be directly used as bone replacement materials [171]. The combination with CNTs is expected to optimize properties of collagen materials thus making them suitable for use as biomimetic composite scaffolds in bone tissue engineering.…”
Section: Advancements In Cnt-based Scaffolds or Implants For Bone mentioning
confidence: 99%
“…Collagen has been clinically applied as a promising biomaterial to regenerate bone tissue due to the fact of its biodegradation, low antigenicity, and cytocompatibility [168,169,170]. Pure collagen are relatively soft (elastic modulus: 14.6 ± 2.8 kPa) and cannot be directly used as bone replacement materials [171]. The combination with CNTs is expected to optimize properties of collagen materials thus making them suitable for use as biomimetic composite scaffolds in bone tissue engineering.…”
Section: Advancements In Cnt-based Scaffolds or Implants For Bone mentioning
confidence: 99%
“…Because of its bioremediation, lower antigenicity, and excellent biocompatibility, collagen has been proposed as a nanomaterial for reconstructing bone tissue [ 56 , 57 , 58 ]. Natural collagen is slightly softer and cannot be used directly as a bone substitute [ 59 ]. A mixture of CNTs can enhance the stability of collagen components, making them ideal for use in bone regeneration as biocompatible structural scaffolds.…”
Section: Cnt–polymer Composites For Tissue Engineering and Regenermentioning
confidence: 99%
“…An understanding of and prediction of the soaking and drying phenomena are relevant to various situations including food processing and preservation (Welti-Chanes, Velez-Ruiz & Barbosa-Canovas 2016), functional fabric design (Vasiliev 2008), landslides (Take et al 2004) and building safety (Šelih, Sousa & Bremner 1994). We also note that highly absorbent sponges are finding diverse medical applications including dressing, wound healing (Kobatake, Mita & Kato 2015;Lee et al 2016a) and dental treatments (Castro-Ceseña et al 2016), where liquid imbibition dynamics plays an important role.…”
Section: Introductionmentioning
confidence: 97%