Antimicrobial resistance in cystic fibrosis isolates of<i>Haemophilus influenzae</i>

Atkinson, Christopher T.; Tristram, Stephen

doi:10.1080/09674845.2016.1165408

Cited by 8 publications

(12 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…from urine and the hospital environment. Atkinson and Tristram [55] also focussed on CF, but upon infections with Haemophilus influenzae. One of the drivers of their study was a report of an increased frequency of antibiotic resistance by this organism in CF patients [56].…”

Section: Cell Pathologymentioning

confidence: 99%

British Journal of Biomedical Science in 2016. What have we learned?

Blann

2017

British Journal of Biomedical Science

View full text Add to dashboard Cite

In 2016, the British Journal of Biomedical Science published 36 reports outlining specific advances in each of the various disciplines within biomedical science. These were one review, 25 original articles, 9 'In Brief' reports and one letter to the Editor. Of these, the majority were in blood science (5 in biochemistry, 7 in haematology and 2 in immunology) and infection science (8 in microbiology, 2 in virology) with a smaller number in cellular sciences (6 in cellular pathology and 2 in cytopathology). Three reports considered both biochemistry and immunology, while another reported an advance in the identification of chromosomal abnormalities. The present report will summarise key aspects of these publications that are of greatest relevance to laboratory scientists.

show abstract

Section: Cell Pathologymentioning

confidence: 99%

British Journal of Biomedical Science in 2016. What have we learned?

Blann

2017

British Journal of Biomedical Science

View full text Add to dashboard Cite

show abstract

“…With the advancement of time, microbes become resistant to different antimicrobials and spread the disease without any hindrance. The widespread use and abuse of antimicrobials in the fields of both animal and human health has caused the expansion of resistant bacteria that are resistant to the wide range of medicines that are currently accessible (Tang et al 2023). The growing issue of antibiotic resistance, which has become a serious health hazard in practically every country in the globe, including Pakistan, has been vigorously advocated for by WHO.…”

Section: What Is Resistance To Antimicrobials?mentioning

confidence: 99%

“…Due to its multidimensional, linked, and diverse ecological aspects, understanding the AMR pattern is difficult. The right usage of antimicrobial products in diverse areas must be decided upon by individuals and society as a whole in order to control widespread resistance (Tang et al 2023). A multi-sectoral approach to oversight, involving teams from the veterinary, environmental, and healthcare sectors as well as stakeholders, is necessary to understand the complex AMR situation (McEwen et al 2018).…”

Section: The Widespread Resistance: One Health Approachmentioning

confidence: 99%

Antimicrobial Resistance and Zoonotic Pathogens

2023

IJAB

View full text Add to dashboard Cite

The development of antimicrobial resistance (AMR) poses serious threat to the environment, animal and human health in terms of treatment of the diseases especially zoonotic infections. The ability of microorganisms to withstand the action of antimicrobial therapy has serious consequences for treating bacterial infections and has emerged as a global health concern. Antibiotic resistance has been increased by the irrational use of antibiotics in veterinary care, agriculture and human medicine. This irrational use has made antimicrobial ineffective to treat diseases especially diseases of zoonotic importance. The phenomenon of AMR presents a serious risk to public health in addition to impairing the efficacy of medical interventions. The likelihood of spillover events is raised by the interdependence of ecosystems and the growing connection between humans and animals. The management of infectious diseases is made more challenging by the coexistence of zoonotic pathogens and antimicrobial resistance. The transboundary pathogens have infected the environment globally due to their spread and by developing antimicrobial resistance. The growing issue of antibiotic resistance, which has become a serious health hazard in practically every country in the globe, including Pakistan, has been vigorously advocated for by WHO. 'One Health' offers a variety of strategies to stop the transboundary and zoonotic spread of AMR and maintain the efficient use of antibiotics in both human and animal treatment. Resistant zoonotic pathogen strains have the potential to undermine the efficacy of current therapies, resulting in illnesses that worsen and last longer. Implementing ethical and rational use of antimicrobials, surveillance, and control strategies between human medical care, veterinary care and environmental professions can develop effective measures to reduce the threats of AMR and protect the world from this threat. WHO has started to adopt mitigation measures to have fruitful consequences and pleasant results to cope these conditions effectively.

show abstract

“…The need for alternative preventative therapies for NTHi infections has become apparent following ineffective vaccination attempts and a rapidly evolving antibiotic resistance profile that has resulted in treatment failure with first- and second-line antibiotic regimens [ 4 , 16 , 17 , 18 , 19 , 20 ]. One avenue gaining attention is the use of upper respiratory tract commensals, which may have utility in altering the pharyngeal habitability for pathogens such as NTHi [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Oropharyngeal Carriage of hpl-Containing Haemophilus haemolyticus Predicts Lower Prevalence and Density of NTHi Colonisation in Healthy Adults

et al. 2021

View full text Add to dashboard Cite

Nontypeable Haemophilus influenzae (NTHi) is a major respiratory pathogen that initiates infection by colonising the upper airways. Strategies that interfere with this interaction may therefore have a clinically significant impact on the ability of NTHi to cause disease. We have previously shown that strains of the commensal bacterium Haemophilus haemolyticus (Hh) that produce a novel haem-binding protein, haemophilin, can prevent NTHi growth and interactions with host cells in vitro. We hypothesized that natural pharyngeal carriage of Hh strains with the hpl open reading frame (Hh-hpl+) would be associated with a lower prevalence and/or density of NTHi colonisation in healthy individuals. Oropharyngeal swabs were collected from 257 healthy adults in Australia between 2018 and 2019. Real-time PCR was used to quantitatively compare the oropharyngeal carriage load of NTHi and Hh populations with the Hh-hpl+ or Hh-hpl− genotype. The likelihood of acquiring/maintaining NTHi colonisation status over a two- to six-month period was assessed in individuals that carried either Hh-hpl− (n = 25) or Hh-hpl+ (n = 25). Compared to carriage of Hh-hpl− strains, adult (18–65 years) and elderly (>65 years) participants that were colonised with Hh-hpl+ were 2.43 or 2.67 times less likely to carry NTHi in their oropharynx, respectively. Colonisation with high densities of Hh-hpl+ correlated with a low NTHi carriage load and a 2.63 times lower likelihood of acquiring/maintaining NTHi colonisation status between visits. Together with supporting in vitro studies, these results encourage further investigation into the potential use of Hh-hpl+ as a respiratory probiotic candidate for the prevention of NTHi infection.

show abstract

Antimicrobial resistance in cystic fibrosis isolates ofHaemophilus influenzae

Cited by 8 publications

References 12 publications

British Journal of Biomedical Science in 2016. What have we learned?

British Journal of Biomedical Science in 2016. What have we learned?

Antimicrobial Resistance and Zoonotic Pathogens

Oropharyngeal Carriage of hpl-Containing Haemophilus haemolyticus Predicts Lower Prevalence and Density of NTHi Colonisation in Healthy Adults

Contact Info

Product

Resources

About