Role of follow-up endoscopic examination in treatment response assessment for patients with gastric diffuse large B cell lymphoma

Yoon, Seung Bae; Lee, In Seok; Lee, Ha Ni; Kim, Eun Young; Kim, Woohyeon; Lee, Han Hee; Lee, Bo‐In; Choi, Myung-Gyu; Jung, Seung Eun; Choi, Byung Ock; Park, Gyeong Sin; Cho, Seok-Goo

doi:10.1080/00365521.2016.1177854

Cited by 2 publications

(1 citation statement)

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“…Studies (El-Galaly et al 2014 ; Yang et al 2011 ) have confirmed that imaging examinations play an important role in the assessment of response in patients with gastric DLBCL after treatment. Yoon et al ( 2016 ) explored the utility of endoscopy during and after DLBCL treatment. They suggested that in addition to radiological examinations, endoscopy and biopsy should also be performed; however, the number of patients included in their study was small, only 45 cases; thus, there may be selection bias.…”

Section: Discussionmentioning

confidence: 99%

A new nomogram for assessing complete response (CR) in gastric diffuse large B-cell lymphoma (DLBCL) patients after chemotherapy

Wang,

Chen,

Wang

et al. 2023

J Cancer Res Clin Oncol

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Purpose Achieving complete response (CR) after first-line chemotherapy in gastric DLBCL patients often results in longer disease-free survival. We explored whether a model based on imaging features combined with clinicopathological factors could assess the CR to chemotherapy in patients with gastric DLBCL. Methods Univariate (P < 0.10) and multivariate (P < 0.05) analyses were used to identify factors associated with a CR to treatment. As a result, a system was developed to evaluate whether gastric DLBCL patients had a CR to chemotherapy. Evidence was found to support the model's ability to predict outcomes and demonstrate clinical value. Results We retrospectively analysed 108 people who had been diagnosed gastric DLBCL; 53 were in CR. Patients were divided at random into a 5:4 training/testing dataset split. β2 microglobulin before and after chemotherapy and lesion length after chemotherapy were independent predictors of the CR of gastric DLBCL patients after chemotherapy. These factors were used in the predictive model construction. In the training dataset, the area under the curve (AUC) of the model was 0.929, the specificity was 0.806, and the sensitivity was 0.862. In the testing dataset, the model had an AUC of 0.957, specificity of 0.792, and sensitivity of 0.958. The AUC did not differ significantly between the training and testing dates (P > 0.05). Conclusion A model constructed using imaging features combined with clinicopathological factors could effectively evaluate the CR to chemotherapy in gastric DLBCL patients. The predictive model can facilitate the monitoring of patients and be used to adjust individualised treatment plans.

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Section: Discussionmentioning

confidence: 99%

A new nomogram for assessing complete response (CR) in gastric diffuse large B-cell lymphoma (DLBCL) patients after chemotherapy

Wang,

Chen,

Wang

et al. 2023

J Cancer Res Clin Oncol

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Outcome and patterns of relapse in primary gastric diffuse large B cell lymphoma treated with RCHOP

et al. 2023

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Role of follow-up endoscopic examination in treatment response assessment for patients with gastric diffuse large B cell lymphoma

Abstract: In gastric DLBCL patients, endoscopic response does not always correlate with radiologic response and might predict disease recurrence. We suggest that follow-up endoscopic examination with biopsy should be performed in addition to radiologic examination.

Cited by 2 publications

References 20 publications

A new nomogram for assessing complete response (CR) in gastric diffuse large B-cell lymphoma (DLBCL) patients after chemotherapy

A new nomogram for assessing complete response (CR) in gastric diffuse large B-cell lymphoma (DLBCL) patients after chemotherapy

Outcome and patterns of relapse in primary gastric diffuse large B cell lymphoma treated with RCHOP

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