Adenoma of the Nonpigmented Ciliary Body and Iris Epithelium in Mexican Mestizo Patients

Serna‐Ojeda, Juan Carlos; Ariza-Camacho, Enrique; Collado-Solórzano, Alberto; Flores-Sánchez, Blanca C.; Rodríguez-Reyes, Abelardo; Fulda-Graue, Emiliano

doi:10.1159/000381066

Cited by 8 publications

(6 citation statements)

References 9 publications

(8 reference statements)

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“…In our case, the tumor was composed of solid and tubular components, but most of the tubular components were outside the iris, while most of the solid components were inside the iris. Adenoma of the NPCE shows negative immunoreactivity for HMB-45 and positive immunoreactivity for S-100 and vimentin in most cases [6, 12, 13, 14, 15]. In some cases, a positive reaction to CK (AE1/AE3) is detected [1, 6, 15], CD68 is focally positive [14] or negative [15], and the proliferation index (MIB-1, Ki-67) is below 10% [14, 15].…”

Section: Discussionmentioning

confidence: 99%

Rare Histological Type of Adenoma of the Nonpigmented Ciliary Epithelium

Ishiahara

Hashida

Asao

et al. 2019

Case Rep Ophthalmol

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We report the rare case of an adenoma of the nonpigmented ciliary epithelium (NPCE). A 67-year-old healthy man presented with a regularly shaped and nonpigmented mass at the iris root of his right eye. His best-corrected visual acuity was 1.5 with normal intraocular pressure. During observation, the size of the tumor remained stable for 1.5 years but then rapidly grew, extending through the iris, and gradually enlarged to the point of compressing the iris. Ultimately, an iridocyclectomy with scleral resection under a lamellar scleral flap was performed. The histopathologic features of the resected tissue were consistent with adenoma of the NPCE. Histopathological analysis showed that the tumor consisted of both tubular and solid components. There were solid lesions inside of the ciliary epithelium and tubular lesions outside. We observed positive immunoreactivity to vimentin and cytokeratin CK (AE1/AE3) and negative reactivity to S-100 and CD68, both rarely associated with adenoma of NPCE. During 1 year of follow-up after the iridocyclectomy, no signs of tumor recurrence were observed.

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Section: Discussionmentioning

confidence: 99%

Rare Histological Type of Adenoma of the Nonpigmented Ciliary Epithelium

Ishiahara

Hashida

Asao

et al. 2019

Case Rep Ophthalmol

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“…Аденома НПЦЭ считается наиболее редким вариантом данной группы опухоли, в литературе в основном описана в виде клинических наблю-дений [7,12]. Представленный нами клинический пример аденомы НПЦЭ у ребенка 13 лет можно отнести к казуистическим случаям, так как опу-бликованы лишь единичные описания этой опу-холи в детском возрасте [2,5,8,12].…”

Section: Discussionunclassified

“…Разнообразная клиническая картина, несмотря на доброкачественный характер пора-жения, может быть причиной ряда локальных осложнений. В большинстве случаев это изме-нения в хрусталике -чаще катаракта, реже -ее сублюксация [2,13]. Именно развитие катаракты становится причиной снижения зрения у боль-ных аденомой НПЦЭ [8,14].…”

Section: Discussionunclassified

“…Их диагностика в значительной степени затруднена, необходима дифференциация с рядом неопластических про-цессов, как правило, с меланомой сосудистой оболочки глаза [1,2]. Диагноз опухоли обычно ставится на основании данных патоморфологи-ческого исследования после ее локальной эксци-зии либо энуклеации.…”

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Adenoma of the non-pigmented ciliary epithelium in a 13-year old child

et al. 2017

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“…These lumina were filled with PAS-positive colloid. Initial histological differential diagnoses considered in our case were ectopic lacrimal gland [ 3 ] or sweat gland and iris adenoma [ 4 , 5 ], which could be excluded upon further histological und immunohistochemical examination. Indeed, immunohistochemical staining showed that the lining cells were positively stained with antibodies against cytokeratin AE1/AE3 (cytokeratin 1–8, 10, 14–16 and 19), cytokeratin 18 and BerEP4.…”

Section: Case Presentationmentioning

confidence: 99%

Ectopic thyroid tissue in the iris: a case report

et al. 2021

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Background Ectopic thyroid tissue in the iris, also known as a thyroid glandular epithelial choristoma of the iris, has only been described twice in the literature. In both cases it remained asymptomatic. Case presentation A 67-year-old female patient presented for the first time in mid-2017 with corneal endothelial decompensation, with a history of complicated cataract surgery and IStent® implantation. Slit lamp microscopy showed endothelial decompensation, pseudophakia, anterior synechiae and a whitish iris tumour adhering to the endothelium. The latter had existed since childhood. Given these findings, reduced visual acuity of hand movement perception and an intraocular pressure of 23 mmHg, we performed a keratoplasty combined with an en bloc resection of the iris tumour at 9 o’clock and sector iridectomy at the end of 2019. Histological and immunohistological examination of the iris tumour unexpectedly revealed thyroid tissue. After the procedure described above, the patient had an increase in visual acuity while the graft stayed clear and the eye showed no evidence of tumour recurrence or other complications. Conclusions We report a third case of ectopic thyroid tissue in the iris. Both previous cases remained asymptomatic, whereas in our case, size and location of the ectopic thyroid tissue contributed to a more complex cataract surgery resulting in endothelial decompensation. Therefore, in such cases appropriate patient information should be provided prior to cataract surgery. Furthermore, careful histological examination and examination of the thyroid is important to exclude malignant diagnoses such as a metastasis of a follicular thyroid carcinoma.

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Adenoma of the Nonpigmented Ciliary Body and Iris Epithelium in Mexican Mestizo Patients

Cited by 8 publications

References 9 publications

Rare Histological Type of Adenoma of the Nonpigmented Ciliary Epithelium

Rare Histological Type of Adenoma of the Nonpigmented Ciliary Epithelium

Adenoma of the non-pigmented ciliary epithelium in a 13-year old child

Ectopic thyroid tissue in the iris: a case report

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