Rare Histological Type of Adenoma of the Nonpigmented Ciliary Epithelium

Abstract

We report the rare case of an adenoma of the nonpigmented ciliary epithelium (NPCE). A 67-year-old healthy man presented with a regularly shaped and nonpigmented mass at the iris root of his right eye. His best-corrected visual acuity was 1.5 with normal intraocular pressure. During observation, the size of the tumor remained stable for 1.5 years but then rapidly grew, extending through the iris, and gradually enlarged to the point of compressing the iris. Ultimately, an iridocyclectomy with scleral resection under a lamellar scleral flap was performed. The histopathologic features of the resected tissue were consistent with adenoma of the NPCE. Histopathological analysis showed that the tumor consisted of both tubular and solid components. There were solid lesions inside of the ciliary epithelium and tubular lesions outside. We observed positive immunoreactivity to vimentin and cytokeratin CK (AE1/AE3) and negative reactivity to S-100 and CD68, both rarely associated with adenoma of NPCE. During 1 year of follow-up after the iridocyclectomy, no signs of tumor recurrence were observed.

Partial lamellar sclerouvectomy surgery for anteriorly located uveal tumour resection: a 20-year experience

“…In the previously published papers on the subject, the most common histopathological diagnosis after PLSU was malignant melanoma (51.4-85.3%) [4,[11][12][13]. PLSU was also performed for adenoma of the nonpigmented ciliary epithelium, leiomyoma, medulloepithelioma, and low-grade adenocarcinoma of the retinal pigment epithelium [14][15][16][17][18][19]. In our series, malignant melanoma accounted for 53.6% (30/56) of cases.…”

Adenoma of the nonpigmented ciliary epithelium presenting as glaucoma

“…Adenomas of the non-pigmented epithelium of the ciliary body (NPCEA) are rare, benign neoplasms, with less than 40 cases reported in the English literature. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 NPCEA have been associated with elevated levels of vascular endothelial growth factor (VEGF) in vitreous and aqueous humor. Co-morbidities include rubeosis iridis, secondary glaucoma, vitreous hemorrhage, optic disc neovascularization and macular edema.…”