Neonatal health including congenital malformation risk of 1072 children born after vitrified embryo transfer

Belva, Florence; Bonduelle, M.; Roelants, Mathieu; Verheyen, Greta; Landuyt, L. Van

doi:10.1093/humrep/dew103

Cited by 89 publications

(46 citation statements)

References 46 publications

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“…In twins, neonatal outcomes including birthweight, small-for-gestational age, and prematurity rates were comparable in the vitrified and the fresh group. Furthermore, the rate of major congenital malformations in live-born neonates is comparable between the vitrified group and the fresh group in twins (2.4 vs. 2.7%; AOR: 0.51; 95% CI: 0.05-5.72) [119][120][121][122] .…”

Section: Discussionmentioning

confidence: 85%

Re-Thinking Elective Single Embryo Transfer: Increased Risk of Monochorionic Twinning - A Systematic Review

Dziadosz

Evans²

2017

Fetal Diagn Ther

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Background/Objectives: Multiple pregnancies have tripled in the United States over the past 3 decades. Attributed to increasing maternal age at delivery but more so assisted reproductive technological advances, an effort has been made to decrease twinning through elective single embryo transfer. We sought to review and evaluate risks of monochorionic twinning as a predictable consequence of increasing utilization of elective single embryo transfer on perinatal outcomes. Primary outcomes included twinning rates, fetal anomalies, growth, preterm birth, and mortality. Secondary outcomes included neurological and pulmonary disability, intrauterine growth restriction, and congenital cardiac anomalies and twin-twin transfusion syndrome. Data sources: PubMed and Embase. Results: A total of 106 studies identified by systematic search met the inclusion criteria. The trend for lower numbers of embryos transferred has inadvertently led to an increase in monochorionic twinning. This is associated with worse outcomes compared to dichorionic twinning and singleton gestations for all outcomes studied. Discussion: Of great concern for monochorionic twins is the risk profile of significant morbidity and mortality. Transfer of 2 embryos should be considered to avoid higher risks inherent to the shared placental phenomena related to monochorionic twins.

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Section: Discussionmentioning

confidence: 85%

Re-Thinking Elective Single Embryo Transfer: Increased Risk of Monochorionic Twinning - A Systematic Review

Dziadosz

Evans²

2017

Fetal Diagn Ther

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“…An interesting retrospective study [118] analyzed the perinatal and neonatal health, adjusted for treatment variables and maternal characteristics, after 960 vitrified cycles and 1,644 fresh cycles according to the day of vitrification or fresh transfer, i.e. day 3 (cleavage stage) vs. day 5 (blastocyst stage).…”

Section: Resultsmentioning

confidence: 99%

“…Singletons, but not twins, born after vitrification showed only lower SGA rate (aOR 0.55, 95 % CI 0.34 to 0.90) in comparison with peers born after fresh ET. The embryonic stage at vitrification or at fresh transfer did not influence any perinatal outcome [118]. These data seem to suggest that both vitrification and extensive culture at blastocyst stage can act and interact on fetal/neonatal weight.…”

Section: Resultsmentioning

confidence: 99%

Risk of adverse pregnancy and perinatal outcomes after high technology infertility treatment: a comprehensive systematic review

Palomba

Homburg

Santagni

et al. 2016

Reprod Biol Endocrinol

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In the literature, there is growing evidence that subfertile patients who conceived after infertility treatments have an increased risk of pregnancy and perinatal complications and this is particularly true for patients who conceived through use of high technology infertility treatments. Moreover, high technology infertility treatments include many concomitant clinical and biological risk factors. This review aims to summarize in a systematic fashion the current evidence regarding the relative effect of the different procedures for high technology infertility treatments on the risk of adverse pregnancy and perinatal outcome. A literature search up to August 2016 was performed in IBSS, SocINDEX, Institute for Scientific Information, PubMed, Web of Science and Google Scholar and an evidence-based hierarchy was used to determine which articles to include and analyze. Data on prepregnancy maternal factors, low technology interventions, specific procedures for male factor, ovarian tissue/ovary and uterus transplantation, and chromosomal abnormalities and malformations of the offspring were excluded. The available evidences were analyzed assessing the level and the quality of evidence according to the Oxford Centre for Evidence-Based Medicine guidelines and the Grading of Recommendations Assessment, Development, and Evaluation system, respectively. Current review highlights that every single procedure of high technology infertility treatments can play a crucial role in increasing the risk of pregnancy and perinatal complications. Due to the suboptimal level and quality of the current evidence, further well-designed studies are needed.

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“…Sin embargo, podríamos preguntarnos cuál es la relevancia clínica de esto. Finalmente, este año, un informe de un grupo en Bruselas analizó 1 072 recién nacidos vivos de embarazos únicos y gemelares provenientes de embriones vitrificados en día 3 y 5, concluyendo que los parámetros de salud neonatal, incluida la prevalencia de malformaciones congénitas, eran similares o ligeramente mejores que después de la transferencia de embriones frescos (63) . Se debe tener en cuenta que la mayoría de estos estudios son observacionales y que los embriones vitrificados son siempre la segunda opción para la transferencia.…”

Section: La Preocupación Sobre Los Resultados Perinatales Y Obstétricosunclassified

Freeze-all en reproducción asistida

Basile¹

2018

Rev peru ginecol obstet.

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Los avances en los protocolos de vitrificación y los resultados obtenidos tras la transferencia de embriones congelados han dado lugar a una versión distinta de los ciclos estándar de reproducción asistida: los ciclos freeze-all. Independientemente de su uso frente a las indicaciones más comunes (progesterona elevada, riesgo de hiperestimulación, entre otros), este nuevo concepto hoy representa una práctica habitual en muchas clínicas siendo aplicado a todas las pacientes. En este artículo analizaremos los distintos factores que pudieron haber contribuido a este cambio de política y la evidencia científica en relación al tema. Basados en esta evidencia concluiremos si las clínicas deberían cambiar su forma de trabajo pasando de transferencias de embriones frescos a solo transferencia de embriones congelados o si deberíamos mantener el protocolo estándar.

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Neonatal health including congenital malformation risk of 1072 children born after vitrified embryo transfer

Cited by 89 publications

References 46 publications

Re-Thinking Elective Single Embryo Transfer: Increased Risk of Monochorionic Twinning - A Systematic Review

Re-Thinking Elective Single Embryo Transfer: Increased Risk of Monochorionic Twinning - A Systematic Review

Risk of adverse pregnancy and perinatal outcomes after high technology infertility treatment: a comprehensive systematic review

Freeze-all en reproducción asistida

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