Delayed Absorption of Oxidized Cellulose (Surgicel) in Post‐Thyroidectomy Patients

Liu, Jingyun; Hong, Wandong; Wu, Wenzhi; Ni, Hong-Bo; Zhou, Mengtao

doi:10.7863/ultra.15.08014

Cited by 15 publications

(11 citation statements)

References 4 publications

(8 reference statements)

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“…As the current study shows, FNA cytology constitutes a minimally invasive procedure that permits a rapid and precise diagnosis. Very few cases mentioning cytology have been previously reported in the medical literature, and there have been only 2 concerning the use of oxidized cellulose . Two other cases are related to the use of other hemostatic agents (Floseal and Integran microfibrillar collagen hemostatic matrix) that do not use oxidized cellulose but instead use thrombin and collagen …”

Section: Discussionmentioning

confidence: 99%

“…Image studies do not allow a precise diagnosis, so many of these patients undergo a second surgical procedure because of suspected tumoral recurrence. Cytologic descriptions of pseudotumoral lesions related to hemostatic agents (including oxidized cellulose) are scarce and, to our knowledge, limited to isolated case reports . In this report, we describe our experience with a large series of cases that were studied with fine‐needle aspiration (FNA).…”

Section: Introductionmentioning

confidence: 99%

“…Cytologic descriptions of pseudotumoral lesions related to hemostatic agents (including oxidized cellulose) are scarce and, to our knowledge, limited to isolated case reports. [11][12][13][14] In this report, we describe our experience with a large series of cases that were studied with fine-needle aspiration (FNA). As shown, cytology permits a precise recognition of…”

Section: Introductionmentioning

confidence: 99%

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FNA cytology of postoperative pseudotumoral lesions induced by oxidized cellulose hemostatic agents

Hernández‐Bonilla

Rodríguez-García

Jiménez‐Heffernan

et al. 2019

Cancer Cytopathology

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Background The use of topically applied hemostatic substances during surgery has become a common practice. In some cases, the material is not absorbed or induces a granulomatous reaction resulting in a pseudotumoral lesion. With imaging studies, it is not possible to differentiate this from a tumor recurrence or abscess. This study describes the authors' cytologic experience with a large series of pseudotumoral lesions induced by oxidized cellulose, one of the most commonly used hemostatic agents. Almost no cytologic descriptions are available in the medical literature. Methods Sixteen patients were evaluated, and the most common sites of fine‐needle aspiration (FNA) were the mediastinum and thyroid surgical bed. Other locations were the axilla, neck, vulva, liver, and retroperitoneum. All these lesions appeared after surgical procedures in which oxidized cellulose was used as a topical hemostatic agent. The interval time between surgery and FNA varied from 4 to 46 months with a mean of 15 months. Results Cytology samples showed very similar findings. In all cases, foreign‐body material with a variable granulomatous reaction was present. Oxidized cellulose was seen as laminated inorganic fragments and most often showed an elongated, quadrangular appearance. Amorphous, ill‐defined fragments as well as a dense proteinaceous background with phagocytic cells were also present. Conclusions The current study demonstrates that FNA cytology is a very useful method for the detection of pseudotumoral lesions induced by hemostatic agents. Pathologists must be familiarized with this finding because cytology permits easy differentiation from tumor recurrence.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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FNA cytology of postoperative pseudotumoral lesions induced by oxidized cellulose hemostatic agents

Hernández‐Bonilla

Rodríguez-García

Jiménez‐Heffernan

et al. 2019

Cancer Cytopathology

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“…The sonographic appearance of absorbable surgical hemostatic material, including absorbable gelatin compressed sponges (Gelfoam; Pfizer, Inc, New York, NY) and oxidized cellulose (Surgicel; Johnson & Johnson, New Brunswick, NJ) has also been reported. Although typically absorbed in 4 to 8 weeks, both may persist in some patients for years, appearing as a soft tissue lesion in the surgical bed. Gelfoam has been described as appearing as a nonvascular elongated echogenic lesion with a thin hypoechoic halo .…”

Section: Central Neck Conditions That May Mimic Thyroid Cancer Recurrmentioning

confidence: 99%

“…Gelfoam has been described as appearing as a nonvascular elongated echogenic lesion with a thin hypoechoic halo . Surgicel (Figure and Video 11) has been described as a well‐defined nonvascular hypoechoic mass with punctiform internal echoes within . In both cases, the absence of vascularity, well‐defined margins, elongated shape, lack of calcifications, and temporal stability or involution are features that may help distinguish nonabsorbed surgical material from locally recurrent tumor.…”

Section: Central Neck Conditions That May Mimic Thyroid Cancer Recurrmentioning

confidence: 99%

Surveillance Neck Sonography After Thyroidectomy for Papillary Thyroid Carcinoma: Pitfalls in the Diagnosis of Locally Recurrent and Metastatic Disease

2017

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A sonographic examination of the neck performed 6 to 12 months after thyroid surgery in patients with differentiated thyroid cancer is strongly recommended by the American Thyroid Association and considered mandatory by the European Thyroid Association for locoregional surveillance. The aim of this article is to review the normal anatomic changes expected after thyroid surgery and the pathologic mimics of thyroid carcinoma recurrence in post-thyroidectomy patients as they appear on neck sonography. We hope to offer some pearls to increase diagnostic confidence in this setting.

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Polymer in hemostasis and follow‐up wound healing

Sasmal

Ganguly

2023

J of Applied Polymer Sci

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Polymers offer unique functional properties that lead to some novel applications every other day. Bioactive polymers with high degree of biodegradability, nonimmunogenicity, and biocompatibility are considered for applications in wound healing. The most basic form of wound protection is by gauge dressing that isolates the wound from contaminants. Natural polymers for example, cellulose, alginate, chitosan, starch, dextran, gelatin, hyaluronic acid, glycan, collagen, and synthetic polymers including polymethyl methacrylate (PMMA), polyvinyl alcohol (PVA), polyethylene glycol (PEG), polyvinyl pyrrolidone (PVP) are candidates for these applications. Biopolymers, when applied as wound dressing promote tissue healing and repair by (i) regulating the moist environment, and (ii) providing the needed growth factors, while offering anti-inflammatory, immune-modulatory, and cell proliferative properties. It induces hemostasis via direct interaction with erythrocytes and platelets. These polymers in cross linked state offer a scaffold for cell proliferation, differentiation, and cell migration. Further, these polymeric materials can be utilized to form permeable envelopes around the hemostatic and wound healing agents to leverage a favorable release kinetics. The fabrication strategies and their reported efficacy are reviewed in this article.

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Delayed Absorption of Oxidized Cellulose (Surgicel) in Post‐Thyroidectomy Patients

Cited by 15 publications

References 4 publications

FNA cytology of postoperative pseudotumoral lesions induced by oxidized cellulose hemostatic agents

FNA cytology of postoperative pseudotumoral lesions induced by oxidized cellulose hemostatic agents

Surveillance Neck Sonography After Thyroidectomy for Papillary Thyroid Carcinoma: Pitfalls in the Diagnosis of Locally Recurrent and Metastatic Disease

Polymer in hemostasis and follow‐up wound healing

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