PO-43 - Differential coagulation factor expression in neuroendocrine prostate cancer (PC), metastatic castrate-resistant PC, and localized prostatic adenocarcinoma

Choe, Hannah; Sboner, Andrea; Beltran, Himisha; Nanus, David M.; Tagawa, Scott T.

doi:10.1016/s0049-3848(16)30176-1

Cited by 2 publications

(2 citation statements)

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“…According to IPA analysis and previous studies, LBP is also involved in IL-10 signaling ( 34 ). FGB is related to the coagulation system, the extrinsic prothrombin activation pathway, and role of tissue factor in cancer ( 35 ). SERPINA1 participates in the coagulation system ( 36 ), atherosclerotic signaling ( 37 ), and IL-12 signaling and production in macrophages ( Table II ) ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Quantitative proteomic study of the plasma reveals acute phase response and LXR/RXR and FXR/RXR activation in the chronic unpredictable mild stress mouse model of depression

Yang

Zhou

et al. 2017

Mol Med Report

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Major depressive disorder is a severe neuropsychiatric disease that negatively impacts the quality of life of a large portion of the population. However, the molecular mechanisms underlying depression are still unclear. The pathogenesis of depression involves several brain regions. However, most previous studies have focused only on one specific brain region. Plasma and brain tissues exchange numerous components through the blood-brain barrier. Therefore, in the present study, plasma samples from control (CON) mice and mice subjected to chronic unpredictable mild stress (CUMS) were used to investigate the molecular pathogenesis of depression, and the association between the peripheral circulation and the central nervous system. A total of 47 significant differentially expressed proteins were identified between the CUMS and CON group by an isobaric tag for relative and absolute quantitation (iTRAQ) coupled with tandem mass spectrometry approach. These 47 differentially expressed proteins were analyzed with ingenuity pathway analysis (IPA) software. This revealed that the acute phase response, LXR/RXR and FXR/RXR activation, the complement system and the intrinsic prothrombin activation pathway were significantly changed. Four of the significant differentially expressed proteins (lipopolysaccharide binding protein, fibrinogen β chain, α-1 antitrypsin, and complement factor H) were validated by western blotting. the present findings provide a novel insight into the molecular pathogenesis of depression.

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Section: Discussionmentioning

confidence: 99%

Quantitative proteomic study of the plasma reveals acute phase response and LXR/RXR and FXR/RXR activation in the chronic unpredictable mild stress mouse model of depression

Yang

Zhou

et al. 2017

Mol Med Report

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“…An enrichment analysis of genetic changes during the development of HCC identified several hub genes, including F2, which interacts in several groups of conditional specific PPI networks (42). Additionally, it was reported that F2 is associated with invasion in neuroendocrine prostate cancer (43). Glutamic-oxaloacetic transaminase 2 (GOT2) plays an important role in amino acid metabolism and the tricarboxylic acid cycle, and it affects the malate-aspartic acid shuttle activity and glycolysis in the liver under the stimulation of liver inflammation.…”

Section: )mentioning

confidence: 99%

Big Data-Based Identification of Multi-Gene Prognostic Signatures in Liver Cancer

Liu

et al. 2020

Front. Oncol.

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Simultaneous identification of multiple single genes and multi-gene prognostic signatures with higher efficacy in liver cancer has rarely been reported. Here, 1,173 genes potentially related to the liver cancer prognosis were mined with Coremine, and the gene expression and survival data in 370 samples for overall survival (OS) and 319 samples for disease-free survival (DFS) were retrieved from The Cancer Genome Atlas. Numerous survival analyses results revealed that 39 genes and 28 genes significantly associated with DFS and OS in liver cancer, including 18 and 12 novel genes that have not been systematically reported in relation to the liver cancer prognosis, respectively. Next, totally 9,139 three-gene combinations (including 816 constructed by 18 novel genes) for predicting DFS and 3,276 three-gene combinations (including 220 constructed by 12 novel genes) for predicting OS were constructed based on the above genes, and the top 15 of these four parts three-gene combinations were selected and shown. Moreover, a huge difference between high and low expression group of these three-gene combination was detected, with median survival difference of DFS up to 65.01 months, and of OS up to 83.57 months. The high or low expression group of these three-gene combinations can predict the longest prognosis of DFS and OS is 71.91 months and 102.66 months, and the shortest is 6.24 months and 13.96 months. Quantitative real-time polymerase chain reaction and immunohistochemistry reconfirmed that three genes F2, GOT2, and TRPV1 contained in one of the above combinations, are significantly dysregulated in liver cancer tissues, low expression of F2, GOT2, and TRPV1 is associated with poor prognosis in liver cancer. Overall, we discovered a few novel single genes and multi-gene combinations biomarkers that are closely related to the long-term prognosis of liver cancer, and they can be potential therapeutic targets for liver cancer.

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PO-43 - Differential coagulation factor expression in neuroendocrine prostate cancer (PC), metastatic castrate-resistant PC, and localized prostatic adenocarcinoma

Cited by 2 publications

References 0 publications

Quantitative proteomic study of the plasma reveals acute phase response and LXR/RXR and FXR/RXR activation in the chronic unpredictable mild stress mouse model of depression

Quantitative proteomic study of the plasma reveals acute phase response and LXR/RXR and FXR/RXR activation in the chronic unpredictable mild stress mouse model of depression

Big Data-Based Identification of Multi-Gene Prognostic Signatures in Liver Cancer

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