Neither the patient nor the physician could see anything: Atypical Bing–Neel syndrome

Bacquet, Jean-Louis; Weiss, Nicolas; Meyniel, Claire; Algrin, Caroline; Choquet, Sylvain; Leblond, Véronique; Galanaud, Damien; LeHoang, Phuc; Bodaghi, Bahram

doi:10.1002/ajh.24411

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…The MRI findings were most probably responsible for the lagophthalmos which was the only eye manifestation in our patient. The orbital infiltration in WM occur rarely [11][12][13] and even more rarely occurs simultaneously with CSF involvement. We found single publications in the literature similar to our report with orbital infiltration preceeding meningeal and cerebrospinal fluid infiltration who firstly complained of decreased eye movements bilaterally [14], or with optical neuritis and CNS infiltration [15].…”

Section: Discussionmentioning

confidence: 99%

Bing-Neel Syndrome – A Challenging Diagnosis: Case Report

Davidkova

Simonoski

Spassov

et al. 2020

IBRR

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Bing-Neel syndrome is a rare neurologic complication of Waldenström’s macroglobulinemia, characterized by infiltration of the central nervous system by clonal lymphoplasmacytes. We present a rare clinical case of a patient, who one year after the diagnosis of Waldenström’s macroglobulinemia, progressed with diverse neurologic presentation and cerebrospinal fluid involvement. The diagnosis was based on magnetic resonance imaging and flow cytometry detection of clonal B-cells in the cerebrospinal fluid. Bing-Neel syndrome should be considered in patients with neurologic symptoms and a history of Waldenström’s macroglobulinemia.

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Section: Discussionmentioning

confidence: 99%

Bing-Neel Syndrome – A Challenging Diagnosis: Case Report

Davidkova

Simonoski

Spassov

et al. 2020

IBRR

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“…However, detection of the MYD88 mutation requires specific techniques, such as an allele-specific PCR assay or real-time quantitative PCR. Furthermore, it is often difficult to detect clonality in the CSF by cytology or flow cytometry because of the low rate of cell infiltration into the CSF (19,20). Elevation of the IgM index indicates that the concentration of IgM in the CSF is higher than expected due to passive leakage across the blood-CSF barrier (6,12,21).…”

Section: Discussionmentioning

confidence: 99%

An Autopsy Case of Bing-Neel Syndrome: Discrepancy between the Radiological and Pathological Findings

et al. 2019

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A 64-year-old man previously diagnosed with Waldenstrom's macroglobulinemia presented to our hospital with confusion. Magnetic resonance imaging (MRI) revealed diffuse meningeal enhancement. The patient was diagnosed with Bing-Neel syndrome (BNS) based on an elevated IgM index and the presence of monoclonal IgM protein, as detected by immunofixation electrophoresis of the cerebrospinal fluid. The patient underwent intrathecal and systemic chemotherapy but ultimately died of pneumonia. An autopsy revealed extensive meningeal and perivascular infiltration by malignant cells throughout the brain and spine. Thus, BNS may cause more extensive malignant infiltration into the central nervous system than is revealed by MRI.

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Imaging spectrum of Bing–Neel syndrome: how can a radiologist recognise this rare neurological complication of Waldenström’s macroglobulinemia?

et al. 2018

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• Diagnosis of Bing-Neel syndrome (BNS) remains challenging and recent expert recommendations include MRI in the diagnostic criteria for the syndrome. • The most common radiological manifestations of BNS are leptomeningeal/dural infiltration or parenchymal involvement of brain or spinal cord, but many atypical forms may exist with various presentations. • Appropriate imaging protocol for BNS should include enhanced MRI studies of both brain and spine.

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Neither the patient nor the physician could see anything: Atypical Bing–Neel syndrome

Cited by 3 publications

References 5 publications

Bing-Neel Syndrome – A Challenging Diagnosis: Case Report

Bing-Neel Syndrome – A Challenging Diagnosis: Case Report

An Autopsy Case of Bing-Neel Syndrome: Discrepancy between the Radiological and Pathological Findings

Imaging spectrum of Bing–Neel syndrome: how can a radiologist recognise this rare neurological complication of Waldenström’s macroglobulinemia?

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