Imaging spectrum of Bing–Neel syndrome: how can a radiologist recognise this rare neurological complication of Waldenström’s macroglobulinemia?

Fitsiori, Aikaterini; Fornecker, Luc‐Matthieu; Simon, Laurence; Karentzos, Alexandros; Galanaud, Damien; Outteryck, Olivier; Vermersch, Patrick; Pruvo, Jean‐Pierre; Gérardin, Emmanuel; Lebrun-Frénay, Christine; Lafitte, F.; Cottier, Jean‐Philippe; Clerc, Christine; Sèze, Jérôme De; Dietemann, Jean-Louis; Kremer, Stéphane

doi:10.1007/s00330-018-5543-7

Cited by 28 publications

(19 citation statements)

References 55 publications

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“…22 Although MYD88 L265P mutation is the most common somatic mutation in WM, this is followed closely by CXCR4 WHIM-like frameshift and nonsense mutations. 23,24 Plerixafor is an FDA-approved CXCR4 partial agonist and allosteric antagonist of CXCR7, which has been studied for clinical efficacy and safety in treatment of WHIM syndrome. [25][26][27] In vitro studies have demonstrated that ibrutinib resistance can be potentially reversed by CXCR4 inhibition, yet MYD88 inhibition superseded the survival benefits provided by CXCR4 frameshift mutations.…”

Section: Discussionmentioning

confidence: 99%

Primary central nervous system diffuse large B‐cell lymphoma masqueraded as Bing‐Neel syndrome: Steps in management and review of future directions

Delasos

Phachu

Shetty

et al. 2021

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

Primary central nervous system diffuse large B‐cell lymphoma masqueraded as Bing‐Neel syndrome: Steps in management and review of future directions

Delasos

Phachu

Shetty

et al. 2021

Clinical Case Reports

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“…3 Bing-Neel syndrome (BNS) is a rare and probably underdiagnosed neurological complication of Waldenström macroglobulinemia (WM) with infiltration of the central nervous system (CNS) by malignant lymphoplasmacytic cells. [4][5][6] Herein, we report the case of a 69-year-old Caucasian male patient presenting atypical manifestations of a small B-cell lymphoma, presumed to be a marginal zone lymphoma with plasmacytic differentiation and IgM paraprotein, complicated by CSH and neurological impairment similar to BNS.…”

Section: Introductionmentioning

confidence: 99%

Crystal‐storing histiocytosis and Bing‐Neel‐like syndrome revealing a small B‐cell lymphoma with plasmacytic differentiation, presumed to be a marginal zone lymphoma

Lequain

Gerfaud‐Valentin

Fontaine

et al. 2021

Clinical Case Reports

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“…Gadolinium-enhanced T1-weighted and post-contrast FLAIR MRI remain the most sensitive imaging techniques for diagnosing LMD [3,7,9] as tumor cells adhere to the leptomeninges [10][11][12]. However, in the literature the sensitivity of MRI in this setting ranges between 53 and 79% [13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Ventricular apparent diffusion coefficient measurements in patients with neoplastic leptomeningeal disease

et al. 2020

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Background: To test the hypothesis that intraventricular ADC values can be used to determine the presence of neoplastic leptomeningeal disease (LMD). Materials and methods: ADC values were measured at multiple sites in the ventricular system in 32 patients with cytologically-proven LMD and 40 control subjects. Multiple linear regression analysis was used to determine the mean difference of ADCs between the LMD and control groups after adjusting for ventricle size and tumor type. Receiver operating characteristics (ROC) analysis was performed and optimal ADC value cutoff point for predicting the presence of LMD. ADC was compared to T1 enhancement and FLAIR signal hyperintensity for determining the presence of LMD. Results: After adjusting for ventricular volume and tumor type, the mid body of lateral ventricles showed no significant difference in ventricular volume and a significant difference in ADC values between the control and LMD groups (p > 0.05). In the mid-body of the right lateral ventricle the AUC was 0.69 (95% CI 0.57-0.81) with an optimal ADC cut off point of 3.22 × 10 − 9 m 2 /s (sensitivity, specificity; 0.72, 0.68). In the mid-body of left lateral ventricle the AUC was 0.7 (95% CI 0.58-0.82) with an optimal cutoff point of 3.23 × 10 − 9 m 2 /s (0.81, 0.62). Using an average value of HU measurements in the lateral ventricles the AUC was 0.73 (95% CI 0.61-0.84) with an optimal cut off point was 3.11 × 10 − 9 m 2 /s (0.78, 0.65). Compared to the T1 post-contrast series, ADC was predictive of the presence of LMD in the mid-body of the left lateral ventricle (p = 0.036). Conclusion: Complex interactions affect ADC measurements in patients with LMD. ADC values in the lateral ventricles may provide non-invasive clues to the presence of LMD.

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Imaging spectrum of Bing–Neel syndrome: how can a radiologist recognise this rare neurological complication of Waldenström’s macroglobulinemia?

Cited by 28 publications

References 55 publications

Primary central nervous system diffuse large B‐cell lymphoma masqueraded as Bing‐Neel syndrome: Steps in management and review of future directions

Primary central nervous system diffuse large B‐cell lymphoma masqueraded as Bing‐Neel syndrome: Steps in management and review of future directions

Crystal‐storing histiocytosis and Bing‐Neel‐like syndrome revealing a small B‐cell lymphoma with plasmacytic differentiation, presumed to be a marginal zone lymphoma

Ventricular apparent diffusion coefficient measurements in patients with neoplastic leptomeningeal disease

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