The possible protective effects of dipyridamole on ischemic reperfusion injury of priapism

Abstract

Purpose To investigate the protective effects against ischemia reperfusion injury of dipyridamole in a model of induced priapism in rats.Materials and Methods Twenty-four male Sprague-Dawley rats were divided into four groups, control, P/R, P/R+DMSO and P/R+D. 3ml blood specimens were collected from vena cava inferior in order to determine serum MDA, IMA, TAS, TOS and OSI values, and penile tissue was taken for histopathological examination in control group. Priapism was induced in P/R group. After 1h, priapism was concluded and 30 min reperfusion was performed. In P/R+DMSO group 1ml/kg DMSO was administered intraperitoneally 30 min before reperfusion, while in P/R+D group 10mg/kg dipyridamole was administered intraperitoneally 30 min before reperfusion. Blood and penis specimens were collected after the end of 30 min reperfusion period. Sinusoidal area (µm2), tears in tunica albuginea and injury parameters in sinusoidal endothelium of penis were investigated.Results Histopathological examination revealed no significant changes in term of sinusoidal area. A decrease in tears was observed in P/R+D group compared to P/R group (p<0.05). Endothelial injury decreased in P/R+D group compared to P/R group (p>0.05). There were no significant differences in MDA and IMA values between groups. A significant increase in TOS and OSI values was observed in P/R+D group compared to P/R group. A significant decrease in TAS levels was observed in P/R+D group compared to the P/R group.Conclusions The administration of dipyridamole before reperfusion in ischemic priapism model has a potential protective effect against histopathological injury of the penis.

Re: Dipyridamole reduces penile apoptosis in a rat model of post-prostatectomy erectile dysfunction

“…In conclusion, we believe if the authors extended their treatment period and switched the anaesthesia, not only they would have achieved better apoptosis index, but also would have shown improvement in erectile functional index. For their discovery resembles to Karaguzel's research ( 8 ). Karaguezel applied dipyridamole in reducing acute penile ischemic and reperfusion injury in priapism.…”

Protective effects of dexmedetomidine on ischaemia‐reperfusion injury in an experimental rat model of priapism

“…If it continues, smooth muscle necrosis and fibroblast‐like cells begin to dominate the environment in the 48th hour. In this context, irreversible tissue damage in the corpus cavernosum is inevitable, especially with the persistence of long‐term hypoxic conditions (Karaguzel et al., 2016; Moore et al., 2017). In ischaemic priapism, penile aspiration and local sympathomimetic injection form the first stage of treatment.…”

“…Due to these reasons, an early diagnosis is crucial for patients. Another important point is to maintain the antioxidant system in these cases strong to minimise the effects of ischaemia‐reperfusion injury after treatment (Karaguzel et al., 2016).…”

“…Large population‐based studies report the incidence of priapism, which was lower than 1/100,000 in the ‘90s, as 1.5/100,000 at the beginning of the current century (Eland et al., 2001). Priapism has been divided into three main groups as ischaemic (low flow, veno‐occlusive), nonischaemic (high‐flow, arterial) and intermittent (stuttering) priapism (Karaguzel et al., 2016).…”

“…Minimising this injury is very important for cases not to encounter sexual function disorders after priapism. In this context, an analysis of previous studies revealed that they focused heavily on the protection of cases from ischaemia‐reperfusion injury after priapism treatment (Karaguzel et al., 2016; Yılmaz et al., 2015).…”