Relevance of internal time and circadian robustness for cancer patients

Ortiz‐Tudela, Elisabet; Innominato, Pasquale F.; Rol, María Ángeles; Lévi, Françis; Madrid, Juan Antonio

doi:10.1186/s12885-016-2319-9

Cited by 40 publications

(34 citation statements)

References 52 publications

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“…Thus, through temporal transcriptional control, the clock is able to regulate the timing of the cell cycle. Such circadian gating of cell cycle has practical implication for timing of surgery, radiation therapy, and administration of cell cycle inhibitor drugs for cancer treatments (Dallmann et al, 2016; Levi and Schibler, 2007; Ortiz-Tudela et al, 2016). The clock also regulates inflammation, which is a common cause of metabolic disorders and cancer.…”

Section: 2 Circadian Clock Machinerymentioning

confidence: 99%

Circadian rhythms, time-restricted feeding, and healthy aging

Manoogian

Panda

2017

Ageing Research Reviews

243

187

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Circadian rhythms optimize physiology and health by temporally coordinating cellular function, tissue function, and behavior. These endogenous rhythms dampen with age and thus compromise temporal coordination. Feeding-fasting patterns are an external cue that profoundly influence the robustness of daily biological rhythms. Erratic eating patterns can disrupt the temporal coordination of metabolism and physiology leading to chronic diseases that are also characteristic of aging. However, sustaining a robust feeding-fasting cycle, even without altering nutrition quality or quantity, can prevent or reverse these chronic diseases in experimental models. In humans, epidemiological studies have shown erratic eating patterns increase the risk of disease, whereas sustained feeding-fasting cycles, or prolonged overnight fasting, is correlated with protection from breast cancer. Therefore, optimizing the timing of external cues with defined eating patterns can sustain a robust circadian clock, which may prevent disease and improve prognosis.

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Section: 2 Circadian Clock Machinerymentioning

confidence: 99%

Circadian rhythms, time-restricted feeding, and healthy aging

Manoogian

Panda

2017

Ageing Research Reviews

243

187

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“…Imagine one could have surgeons work at their “best time” and most restored, with also the patient being under surgery when her/his body is most restored. It has successfully been shown that appropriately timed medication and chemotherapy enhance the effectiveness of a treatment both in experimental and clinical situations (Halberg et al, 1980; Hrushesky, 1990; Ortiz-Tudela et al, 2016; Truong et al, 2016). Of course, most hospital routines would need to be restructured to permit such flexibility.…”

Section: Introductionmentioning

confidence: 99%

Circadian phase, circadian period and chronotype are reproducible over months

Kantermann

Eastman

2017

Chronobiology International

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The timing of the circadian clock, circadian period and chronotype varies among individuals. To date, not much is known about how these parameters vary over time in an individual. We performed an analysis of the following five common circadian clock and chronotype measures: 1) the dim light melatonin onset (DLMO, a measure of circadian phase), 2) phase angle of entrainment (the phase the circadian clock assumes within the 24-h day, measured here as the interval between DLMO and bedtime/dark onset), 3) free-running circadian period (tau) from an ultradian forced desynchrony protocol; tau influences circadian phase and phase angle of entrainment, 4) mid-sleep on work-free days (MSF from the Munich ChronoType Questionnaire; MCTQ), and 5) the score from the Morningness-Eveningness Questionnaire (MEQ). The first three are objective physiological measures, and the last two are measures of chronotype obtained from questionnaires. These data were collected from 18 individuals (10 men, 8 women, ages 21 to 44) who participated in two studies with identical protocols for the first 10 days. We show how much these circadian rhythm and chronotype measures changed from the first to the second study. The time between the two studies ranged from 9 months to almost 3 years, depending on the individual. Since the full experiment required living in the laboratory for 14 days, participants were either unemployed, had part-time jobs or were free-lance workers with flexible hours. Thus, they did not have many constraints on their sleep schedules before the studies. The DLMO was measured on the first night in the lab, after free-sleeping at home, and also after sleeping in the lab on fixed 8-h sleep schedules (loosely tailored to their sleep times before entering the laboratory) for four nights. Graphs with lines of unity (when the value from the first study is identical to the value from the second study) showed how much each variable changed from the first to the second study. The DLMO did not change more than 2 h from the first to the second study, except for two participants whose sleep schedules changed the most between studies, a change in sleep times of 3 h. Phase angle did not change more than 2 h regardless of changes in the sleep schedule. Circadian period did not change more than 0.2 h, except for one participant. MSF did not change more than 1 h, except for 2 participants. MEQ did not change more than 10 points and the categories (e.g. M-type) did not change. Pearson’s correlations for the DLMO between the first and second study increased after participants slept in the lab on their individually timed fixed 8-h sleep schedules for four nights. A longer time between the two studies did not increase the difference between any of the variables from the first to the second study. This analysis shows that the circadian clock and chronotype measures were fairly reproducible, even after many months between the two studies.

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“…To establish a rational chronotherapeutic strategy for choosing the appropriate dosing time, it is compulsory to identify the CTS status and predict optimal treatment timing in cancer patients. With respect to this translational point, Ortiz-Tudela and co-workers proposed monitoring of temperature, activity and position of metastatic gastrointestinal cancer patients by employing inner wrist surface Temperature, arm Activity and Position (TAP) [ 195 ]. Pursuing of circadian biomarkers seems smart approach but clinical validation is necessary in that inter- and intra-individual changes for these parameters.…”

Section: Discussionmentioning

confidence: 99%

Molecular Aspects of Circadian Pharmacology and Relevance for Cancer Chronotherapy

Öztürk

Kavaklı

Okyar

2017

IJMS

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The circadian timing system (CTS) controls various biological functions in mammals including xenobiotic metabolism and detoxification, immune functions, cell cycle events, apoptosis and angiogenesis. Although the importance of the CTS is well known in the pharmacology of drugs, it is less appreciated at the clinical level. Genome-wide studies highlighted that the majority of drug target genes are controlled by CTS. This suggests that chronotherapeutic approaches should be taken for many drugs to enhance their effectiveness. Currently chronotherapeutic approaches are successfully applied in the treatment of different types of cancers. The chronotherapy approach has improved the tolerability and antitumor efficacy of anticancer drugs both in experimental animals and in cancer patients. Thus, chronobiological studies have been of importance in determining the most appropriate time of administration of anticancer agents to minimize their side effects or toxicity and enhance treatment efficacy, so as to optimize the therapeutic ratio. This review focuses on the underlying mechanisms of the circadian pharmacology i.e., chronopharmacokinetics and chronopharmacodynamics of anticancer agents with the molecular aspects, and provides an overview of chronotherapy in cancer and some of the recent advances in the development of chronopharmaceutics.

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Relevance of internal time and circadian robustness for cancer patients

Cited by 40 publications

References 52 publications

Circadian rhythms, time-restricted feeding, and healthy aging

Circadian rhythms, time-restricted feeding, and healthy aging

Circadian phase, circadian period and chronotype are reproducible over months

Molecular Aspects of Circadian Pharmacology and Relevance for Cancer Chronotherapy

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