Dermatan sulfate/chitosan polyelectrolyte complex with potential application in the treatment and diagnosis of vascular disease

Rasente, Rita Yanina; Imperiale, Julieta Celeste; Lázaro-Martínez, Juan Manuel; Gualco, Luciana; Oberkersch, Roxana E; Sosnik, Alejandro; Calabrese, Graciela Cristina

doi:10.1016/j.carbpol.2016.02.046

Cited by 30 publications

(16 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another architectural feature of both natural and synthetic polymers is the presence of branches, loops, or other types of molecular topology. While reports on coacervation include variety of branched polymers, the majority of efforts have utilized naturally occurring polymers that are not well defined either chemically or physically . However, advances in polymer chemistry have enabled the synthesis of increasingly dense branched and brush polymer structures.…”

Section: Molecular Designmentioning

confidence: 99%

“…While reports on coacervation include variety of branched polymers, the majority of efforts have utilized naturally occurring polymers that are not well defined either chemically or physically. 19,158,[180][181][182][183] However, advances in polymer chemistry have enabled the synthesis of increasingly dense branched and brush polymer structures. These chemistries represent an intriguing opportunity to explore the steric limitations of electrostatic interactions.…”

Section: Branching and Molecular Topologymentioning

confidence: 99%

“…The modular nature of coacervation allows for the straightforward incorporation of specific targeting moieties. 77,81,181 For instance, the efficacy of two different peptides incorporated onto the corona of coacervate-core micelles has been reported for the targeted delivery of microRNA to treat atherosclerosis. 81 The triggered release of therapeutic cargo can be achieved through a variety of means including changes in pH, ionic strength, or specific degradation events (i.e., proteolysis).…”

Section: Delivery Platformsmentioning

confidence: 99%

See 2 more Smart Citations

Complex coacervate‐based materials for biomedicine

Blocher

Perry

2016

WIREs Nanomed Nanobiotechnol

229

277

View full text Add to dashboard Cite

There has been increasing interest in complex coacervates for deriving and transporting biomaterials. Complex coacervates are a dense, polyelectrolyte-rich liquid that results from the electrostatic complexation of oppositely-charged macro-ions. Coacervates have long been used as a strategy for encapsulation, particularly in food and personal care products. More recent efforts have focused on the utility of this class of materials for the encapsulation of small molecules, proteins, RNA, DNA, and other biomaterials for applications ranging from sensing to biomedicine. Furthermore, coacervate-related materials have found utility as in other areas of biomedicine, including cartilage mimics, tissue culture scaffolds, and adhesives for wet, biological environments. Here, we discuss the self-assembly of complex coacervate-based materials, current challenges in the intelligent design of these materials, and their utility applications in the broad field of biomedicine.

show abstract

Section: Molecular Designmentioning

confidence: 99%

Section: Branching and Molecular Topologymentioning

confidence: 99%

Section: Delivery Platformsmentioning

confidence: 99%

See 1 more Smart Citation

Complex coacervate‐based materials for biomedicine

Blocher

Perry

2016

WIREs Nanomed Nanobiotechnol

229

277

View full text Add to dashboard Cite

show abstract

“…To characterize the chemical modifications in the modified crosslinked chitosan mini‐spheres, 13 C CP‐MAS spectra were performed on each synthetic step and the results are shown in Figure . The characteristic resonance signals for the chitosan structures (Figure A) remained in the mini‐spheres crosslinked with 250 mM of epichlorohydrin solution (Figure B) . In addition, a significant broadening of the NMR signals was observed due to the random confinement of the chitosan structure during the formation of the spheres.…”

Section: Resultsmentioning

confidence: 98%

“…The characteristic resonance signals for the chitosan structures ( Figure 2A) remained in the minispheres crosslinked with 250 mM of epichlorohydrin solution ( Figure 2B). 25 In addition, a significant broadening of the NMR signals was observed due to the random confinement of the chitosan structure during the formation of the spheres. This behavior can be particularly observed in the C 1 signal at around 97-107 ppm since it is a well resolved signal without the superposition with another NMR signal.…”

Section: Physico-chemical Characterization Of the Matrixmentioning

confidence: 99%

Sulfanilic acid‐modified chitosan mini‐spheres and their application for lysozyme purification from egg white

Hirsch

Baieli

Urtasun

et al. 2017

Biotechnology Progress

View full text Add to dashboard Cite

A cation exchange matrix with zwitterionic and multimodal properties was synthesized by a simple reaction sequence coupling sulfanilic acid to a chitosan based support. The novel chromatographic matrix was physico-chemically characterized by ss-NMR and ζ potential, and its chromatographic performance was evaluated for lysozyme purification from diluted egg white. The maximum adsorption capacity, calculated according to Langmuir adsorption isotherm, was 50.07 ± 1.47 mg g while the dissociation constant was 0.074 ± 0.012 mg mL . The process for lysozyme purification from egg white was optimized, with 81.9% yield and a purity degree of 86.5%, according to RP-HPLC analysis. This work shows novel possible applications of chitosan based materials. The simple synthesis reactions combined with the simple mode of use of the chitosan matrix represents a novel method to purify proteins from raw starting materials. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 34:387-396, 2018.

show abstract

Recent Advances in Antiinflammatory Material Design

Lebaudy

Fournel

Lavalle

et al. 2020

Adv Healthcare Materials

View full text Add to dashboard Cite

Implants and prostheses are widely used to replace damaged tissues or to treat various diseases. However, besides the risk of bacterial or fungal infection, an inflammatory response usually occurs. Here, recent progress in the field of anti‐inflammatory biomaterials is described. Different materials and approaches are used to decrease the inflammatory response, including hydrogels, nanoparticles, implant surface coating by polymers, and a variety of systems for anti‐inflammatory drug delivery. Complex multifunctional systems dealing with inflammation, microbial infection, bone regeneration, or angiogenesis are also described. New promising stimuli‐responsive systems, such as pH‐ and temperature‐responsive materials, are also being developed that would enable an “intelligent” antiinflammatory response when the inflammation occurs. Together, different approaches hold promise for creation of novel multifunctional smart materials allowing better implant integration and tissue regeneration.

show abstract

Dermatan sulfate/chitosan polyelectrolyte complex with potential application in the treatment and diagnosis of vascular disease

Cited by 30 publications

References 43 publications

Complex coacervate‐based materials for biomedicine

Complex coacervate‐based materials for biomedicine

Sulfanilic acid‐modified chitosan mini‐spheres and their application for lysozyme purification from egg white

Recent Advances in Antiinflammatory Material Design

Contact Info

Product

Resources

About