Development of the Fetal Vermis: New Biometry Reference Data and Comparison of 3 Diagnostic Modalities-3D Ultrasound, 2D Ultrasound, and MR Imaging

Katorza, E.; Bertucci, Emma; Perlman, Sharon; Taschini, S.; Ber, Roee; Gilboa, Yinon; Mazza, Vincenzo; Achiron, Reuven

doi:10.3174/ajnr.a4725

Cited by 29 publications

(30 citation statements)

References 25 publications

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“…With advances in fetal ultrasound technology, the mid‐sagittal view of the fetal brain can be easily obtained by 3D‐US, which is vital in order to differentiate PFA. The success rate of 3D‐US volume imaging obtaining the midsagittal plane has been proved to be better than 2D‐US . In this study, adequate visualization of the midsagittal plane of 3D‐US volume imaging was obtained in 96.7% (58/60) of the fetuses.…”

Section: Discussionmentioning

confidence: 61%

“…It is essential to diagnose the type of PFA as accurately as possible, as it reflects on various prognosis and postnatal outcome, which may guide efforts of detection of associated malformations, both within and outside of the CNS.With advances in fetal ultrasound technology, the mid-sagittal view of the fetal brain can be easily obtained by 3D-US, which is vital in order to differentiate PFA. The success rate of 3D-US volume imaging obtaining the midsagittal plane has been proved to be better than 2D-US 10,12. In this study, adequate visualization of the midsagittalplane of 3D-US volume imaging was obtained in 96.7% (58/60) of the fetuses.…”

mentioning

confidence: 58%

“…First, the linear equation applied to calculate the normal fetal SAV with different GA in this study was produced by volunteers from Turkey, and there may be some differences in the characteristics of the Chinese. Second, this does not influence the results indicating that the normal formula was calculated by 2D‐US instead of 3D‐US as some studies demonstrated that 2D‐US and 3D‐US imaging modalities correlated well in measuring cerebellar vermis for normal fetuses . However, 3D‐US technology has significantly improved the display rate of the midsagittal plane for fetal posterior fossa images in comparison to 2D‐US, which was easily affected by fetal position and the acoustic shadow from the bony fetal skull and bony maternal pelvis .…”

Section: Discussionmentioning

confidence: 99%

“…With the development of the ultrasound technique, the midsagittal plane of the fetal brain can be obtained rapidly and clearly by using three‐dimensional ultrasound (3D‐US) volume imaging. Some nomograms were developed to establish normal measurements of the fetal vermis using 3D‐US or magnetic resonance imaging (MRI), and it has been confirmed that the inter‐ and intra‐observer agreement proved to be excellent for these modalities . Several studies have focused on the 3D‐US features of fetal PFA, however, quantitative evaluation of 3D‐US volume imaging including both biometric measures of the fetal vermis and the anatomical angle of the fetal brain in the prenatal diagnosis of PFA has been poorly described in the literature so far.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative diagnostic advantages of three‐dimensional ultrasound volume imaging for fetal posterior fossa anomalies: Preliminary establishment of a prediction model

et al. 2019

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Objectives To quantitatively assess prenatal diagnostic performance of three‐dimensional ultrasound (3D‐US) for posterior fossa anomalies (PFA) and establish a preliminarily 3D‐US prediction model. Methods Sixty singleton fetuses suspected of PFA by 2D‐US presented their detailed 3D‐US evaluation. The surface area of vermis (SAV), brainstem‐vermis, and brainstem‐tentorium angles were measured by 3D‐US. The good prognosis was defined as normal neurodevelopmental outcome. MRI and autopsy were the diagnostic reference standard. Results There was a significant difference between 2D‐US (60.0%, 36/60) and 3D‐US (94.8%, 55/58) for the diagnostic accuracy (P < .01). Prenatal 3D‐US prediction model was established with observed/expected SAV as the main predictor (area under the curve [AUC]: 0.901; 95% CI, 0.810‐0.992, P < .001). When it was more than 107.5%, the prognosis seemed to be good (sensitivity: 96.4%, specificity: 26.7%), which led to consideration of mega cisterna magna, Blake pouch cyst, or small arachnoid cyst. The prognosis appeared to be poor when it was less than 73% (sensitivity: 71.4%, specificity: 100%), and the diagnosis tended to be a Dandy‐Walker malformation, vermian hypoplasia, and cerebellar hypoplasia. Brainstem–vermis and brainstem–tentorium angles were the secondary indicators (AUC: 0.689 vs 0.761; 95% CI, 0.541‐0.836 vs 0.624‐0.897, P = .014 vs.001). Conclusions It seems that the exact types of PFA can be effectively diagnosed by quantitative indicators of 3D‐US.

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Section: Discussionmentioning

confidence: 61%

mentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Quantitative diagnostic advantages of three‐dimensional ultrasound volume imaging for fetal posterior fossa anomalies: Preliminary establishment of a prediction model

et al. 2019

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“…A study with large case numbers was published by Cignini [23]. Another publication [24] evaluated various biometric characteristics of the vermis (height, AP diameter, circumference and area) and compared three different diagnostic tools, namely, 2 D and 3 D ultrasound, and MRI. The lowest measurements were achieved with MRI, the highest with 3 D ultrasound.…”

Section: Vermismentioning

confidence: 99%

The Fetal Posterior Fossa on Prenatal Ultrasound Imaging: Normal Longitudinal Development and Posterior Fossa Anomalies

Pertl¹,

Eder²,

Stern³

et al. 2019

Ultraschall in Med

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Fetal neurosonography and the assessment of the posterior fossa have gained in importance during the last 2 decades primarily due to the development of high-resolution ultrasound probes and the introduction of 3 D sonography. The anatomical development of the posterior fossa can be visualized well with the newest ultrasound technologies. This allows better knowledge of the anatomical structures and helps with understanding of the development of malformations of the posterior fossa. In this article the longitudinal development of the posterior fossa structures will be reviewed. The embryologic description will be compared with ultrasound descriptions. These embryologic and anatomic illustrations form the basis for the screening and diagnosis of malformations of the posterior fossa. During the first trimester, screening for open spina bifida as well as cystic malformations of the posterior fossa is possible. In the second and third trimester, malformations of the posterior fossa can be subdivided into 3 groups: fluid accumulation in the posterior fossa (Dandy-Walker malformation, Blake’s pouch cyst, mega cisterna magna, arachnoid cyst, vermian hypoplasia), decreased cerebellar biometrics (volume) (cerebellar hypoplasia, pontocerebellar hypoplasia) and suspicious cerebellar anatomy (Arnold-Chiari malformation, rhombencephalosynapsis, Joubert syndrome). This algorithm, in combination with knowledge of normal development, facilitates the diagnostic workup of malformations of the posterior fossa.

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Establishment of nomograms for fetal vermis and brainstem structures in the midsagittal cranial plane by ultrasonography

Alpay

Davutoğlu

Kaymak

et al. 2021

J of Clinical Ultrasound

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Purpose To construct nomograms for the fetal cerebellar vermis and brainstem structures obtainable from the midsagittal plane of the brain by two‐dimensional sonography. Methods This was a prospective cross‐sectional study of 434 healthy fetuses in low‐risk singleton pregnancies between 18 and 35 gestational weeks. The following parameters were evaluated in the midsagittal cranial plane; cerebellar vermis anteroposterior diameter (APD), craniocaudal diameter (CCD), pons, midbrain and medulla oblongata APD and tectum length. The measurements were presented as growth charts according to gestational age. Results The mean ± SD, and 5%, 50%, 95% centile charts according to gestational age for vermis APD and CCD, pons, midbrain and medulla oblongata APD and tectum length were constructed. Pearson's correlation coefficients for vermis CCD and APD, pons, midbrain, medulla oblongata APD and tectum length by gestational week were 0.961, 0.929, 0.918, 0.761, 0.731 and 0.854, respectively (p < 0.0001). Conclusion The reference data provided in the present study would be helpful in the prenatal diagnosis of challenging fetal conditions with involvement of the brainstem and cerebellum.

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Development of the Fetal Vermis: New Biometry Reference Data and Comparison of 3 Diagnostic Modalities-3D Ultrasound, 2D Ultrasound, and MR Imaging

Cited by 29 publications

References 25 publications

Quantitative diagnostic advantages of three‐dimensional ultrasound volume imaging for fetal posterior fossa anomalies: Preliminary establishment of a prediction model

Quantitative diagnostic advantages of three‐dimensional ultrasound volume imaging for fetal posterior fossa anomalies: Preliminary establishment of a prediction model

The Fetal Posterior Fossa on Prenatal Ultrasound Imaging: Normal Longitudinal Development and Posterior Fossa Anomalies

Establishment of nomograms for fetal vermis and brainstem structures in the midsagittal cranial plane by ultrasonography

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