Establishment of nomograms for fetal vermis and brainstem structures in the midsagittal cranial plane by ultrasonography

Abstract

Purpose To construct nomograms for the fetal cerebellar vermis and brainstem structures obtainable from the midsagittal plane of the brain by two‐dimensional sonography. Methods This was a prospective cross‐sectional study of 434 healthy fetuses in low‐risk singleton pregnancies between 18 and 35 gestational weeks. The following parameters were evaluated in the midsagittal cranial plane; cerebellar vermis anteroposterior diameter (APD), craniocaudal diameter (CCD), pons, midbrain and medulla oblongata APD and tectum length. The measurements were presented as growth charts according to gestational age. Results The mean ± SD, and 5%, 50%, 95% centile charts according to gestational age for vermis APD and CCD, pons, midbrain and medulla oblongata APD and tectum length were constructed. Pearson's correlation coefficients for vermis CCD and APD, pons, midbrain, medulla oblongata APD and tectum length by gestational week were 0.961, 0.929, 0.918, 0.761, 0.731 and 0.854, respectively (p < 0.0001). Conclusion The reference data provided in the present study would be helpful in the prenatal diagnosis of challenging fetal conditions with involvement of the brainstem and cerebellum.

Fetal Cerebellar Area: Ultrasound Reference Ranges at 13–39 Weeks of Gestation

“…For example, Rizzo et al [ 11 ] established reference limits for the cerebellar vermis using three-dimensional ultrasonography images. Alpay et al [ 12 ] constructed nomograms for brainstem structures using two-dimensional ultrasonography (2D-US). A study by Chang et al [ 13 ] demonstrated the effectiveness of three-dimensional ultrasound in assessing fetal cerebellar volume throughout normal gestation, leading to the development of volume-based nomograms.…”