Postcomparison of [¹⁸F]‐fluorodeoxyglucose uptake in the brain after short‐term bright light exposure and no intervention

Abstract

The present findings suggest a possibility that 5-day bright light exposure may increase [(18) F]FDG in the right olfactory bulb of the human brain, suggesting a possibility of neurogenesis. Further studies are warranted to directly confirm this possibility.

Serotonin transporter binding is reduced in seasonal affective disorder following light therapy

“…Third, the present study demonstrates the influence of light therapy on one therapeutic target, but other targets may also be important in regards to predicting treatment response. For example, Kohno et al, using PET, recently found increased uptake of [ 18 F]‐fluorodeoxyglucose in the right olfactory bulb of healthy humans after light therapy . Fourth, while [ 11 C]DASB has strong preferential binding to 5‐HTT on outer cell membranes, 5‐HTT BP ND is a measure of both 5‐HTT density and its affinity for [ 11 C]DASB ) .…”

Relationship between ambient light and glucose metabolism in healthy subjects

“…Briefly, we used the data of 28 healthy participants of the no intervention group from our previous randomized controlled trial [ 4 ] comparing 5-day bright light exposure plus ambient light (bright light exposure group) versus ambient light alone (no intervention group). The Institutional Review Board of Oita University Faculty of Medicine approved the study and written informed consent was obtained from the participants and their anonymity was preserved.…”

“…In a previous study, we investigated whether bright light exposure increased [ 18 F]- fluorodeoxyglucose (FDG) uptake in the olfactory bulb and/or hippocampus in a randomized controlled trial, which compared 5-day bright light exposure plus ambient light (bright light exposure group, 27 healthy participants) with ambient light alone (no intervention group, 28 healthy participants) [ 4 ]. After adjustment for log-transformed ambient light, there remained a significant increase of uptake in the right olfactory bulb [ 4 ].…”

“…In a previous study, we investigated whether bright light exposure increased [ 18 F]- fluorodeoxyglucose (FDG) uptake in the olfactory bulb and/or hippocampus in a randomized controlled trial, which compared 5-day bright light exposure plus ambient light (bright light exposure group, 27 healthy participants) with ambient light alone (no intervention group, 28 healthy participants) [ 4 ]. After adjustment for log-transformed ambient light, there remained a significant increase of uptake in the right olfactory bulb [ 4 ]. In the present study, as a completely different study, we focused on the no intervention group of the study [ 4 ] and analyzed the association between ambient light and [ 18 F]-FDG uptake in the brain, in order to investigate the effects of ambient light on glucose metabolism in the brain.…”

“…After adjustment for log-transformed ambient light, there remained a significant increase of uptake in the right olfactory bulb [ 4 ]. In the present study, as a completely different study, we focused on the no intervention group of the study [ 4 ] and analyzed the association between ambient light and [ 18 F]-FDG uptake in the brain, in order to investigate the effects of ambient light on glucose metabolism in the brain.…”