Increase in the left hippocampal dentate gyrus head volume after a 4-week bright light exposure in healthy participants: A randomized controlled study

Increased volume of the left hippocampal dentate gyrus after 4 weeks of bright light exposure in patients with mood disorders: a randomized controlled study

“…These results could be due to the effect of the dominant hemisphere since all patients in this study were right-handed. Additionally, this left lateralization was consistent with our prior observation that 4 weeks of BL in healthy individuals increased the volume of the left hippocampal DG-head [7]. However, the possible in uence of mood stabilizers such as lithium and antidepressants on the increased DG volume cannot be ruled out entirely.…”

“…A study using 5-bromo-2′-deoxyuridine as a marker of cell proliferation reported that 4 weeks of BLT induced neurogenesis in the adult rat hippocampal DG [6], thus prompting our hypothesis that BLT may also induce neurogenesis in the human hippocampus, particularly in the DG. To explore our hypothesis, we recently conducted a randomized controlled trial which revealed that a 4-week period of BLT in healthy participants resulted in an increase in the volume of the left hippocampal DG-head [7]. Our study was the rst investigation into the relationship between BLT and volumetric changes in the human hippocampal DG, and the results suggested that neurogenesis may be induced by BLT in the human DG [7].…”

“…To explore our hypothesis, we recently conducted a randomized controlled trial which revealed that a 4-week period of BLT in healthy participants resulted in an increase in the volume of the left hippocampal DG-head [7]. Our study was the rst investigation into the relationship between BLT and volumetric changes in the human hippocampal DG, and the results suggested that neurogenesis may be induced by BLT in the human DG [7]. Considering that the participants in our previous study were healthy individuals, the aim of the current randomized controlled trial was to further investigate the effects of light therapy (BLT vs. dim light therapy) on the hippocampal DG and the correlation between alterations in DG volume and the amelioration of depressive symptoms in a sample population of patients with mood disorders.…”

Increasing the uptake of 18F‐fluorodeoxyglucose in the left hippocampus after 4 weeks of bright light exposure in healthy participants: A randomized controlled study

“…3 This research letter used and analyzed the data of 18 F-FDG positron emission tomography (PET), which was performed simultaneously with magnetic resonance imaging in the previous study. 3…”

A New Potential Antidepressant: Dexmedetomidine Alleviates Neuropathic Pain-Induced Depression by Increasing Neurogenesis in the Hippocampus

“…A previous study also observed that the hippocampal volume in depressed patients was significantly smaller than that in the normal control group, whereas the higher the incidence of depressive disorders, the smaller the hippocampal volume [22]. Hence, an increase in hippocampal volume accompanied groups that experienced improved depression [23, 24]. Furthermore, the hippocampus as an area of the mammalian central nervous system where new neurons can be produced throughout life [25, 26] has been detected the center for neurogenesis, thereby making it the target for treating central nervous system (CNS) diseases.…”