“…For example, the TOR complex is involved in nutrient sensing in eukaryotes and has been shown to be highly phosphorylated under cellulolytic conditions in N. crassa (Wullschleger et al, 2006;Xiong et al, 2014a). Putative ubiquitination and deubiquitination enzymes, such as CreB/CRE-2 and CreD, have been implicated in CCR and glycosyl hydrolase production potentially through ubiquitination of CreA itself, however, additional protein targets and the precise mechanism of action of the genes involved has yet to be identified (Boase and Kelly, 2004;Colabardini et al, 2012;Denton and Kelly, 2011;Kelly, 2001, 2002;Ries et al, 2016;Xiong et al, 2014b). The elucidation of the role of these and other highly conserved actors like the AMP-activated kinase, SnfA/SNF1, in the repression of plant cell wall degrading enzymes could help illuminate the regulation of transcription under cellulolytic conditions as well as nutrient-sensing pathways in eukaryotic species.…”