Ozone Gas Bath Combined with Endovenous Laser Therapy for Lower Limb Venous Ulcers: A Randomized Clinical Trial

Zhou, Yongzhao; Zhao, Xudong; Jiang, Jinju; Li, Xinsheng; Wu, Zhuangzhi

doi:10.3109/08941939.2016.1149637

Cited by 9 publications

(17 citation statements)

References 26 publications

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“…31 Zhou et al also examined the effectiveness of the oxygen-ozone therapy as a supplementary method of lower limb venous ulcers treatment. 32 One of the most important findings of this study is that infection of the ulcer has been reduced due to the O 2 -O 3 therapy. As it was stated previously, ozone disrupts the integrity of bacterial cell walls, thus demonstrating antimicrobial properties.…”

Section: Evidence Of Ozone Therapy Effectiveness In Clinical Trialsmentioning

confidence: 67%

“…Zhou et al provide clinical evidence that the oxygen-ozone therapy may be a successful infection treatment among diabetic patients as well. 32 The observation of higher recovery ratio, higher patient's satisfaction and lower recurrence rate has been made when the patients were preconditioned with ozone gas bath. It is worth noting that just seven to 13 sessions were enough to exert long-term effects.…”

Section: Evidence Of Ozone Therapy Effectiveness In Clinical Trialsmentioning

confidence: 99%

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Oxygen-Ozone (O2-O3) Therapy in Peripheral Arterial Disease (PAD): A Review Study

Juchniewicz

Lubkowska

2020

TCRM

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The purpose of this study is to review the current knowledge of oxygen-ozone (O 2 -O 3 ) therapy and its effects on peripheral artery disease (PAD) risk factors, symptoms, as well as on PAD patients' quality of life. From the in vitro studies, it has been concluded that the oxygen-ozone therapy exerts a positive effect on the platelet aggregation, cell remodeling, cytoskeletal elements organization and mitochondria structure. In animal studies, it has been shown that the O 2 -O 3 therapy is an effective method in hypertension, and it diminishes the hypoxia state of various tissues. Clinical studies have provided evidence on the oxygenozone therapy effectiveness in low perfusion syndromes and hyperglycemia, as well as conditions with oxidative stress and inflammation. The oxygen-ozone therapy promotes faster recovery and enhances healing processes. It appears to be an effective adjunctive therapy in preventing peripheral artery disease complications such as occurrence of cardiovascular event, amputation or other extreme surgical solutions. It has been concluded that the O 2 -O 3 therapy improves the quality of life of PAD patients. The oxygen-ozone therapy appears to have no adverse events or side effects. Moreover, it is very cost-effective, as standard treatment costs can be reduced by 25%. Easy clinical protocols allow the implementation of oxygen-ozone therapy into the usual care of PAD patients. Finally, the O 2 -O 3 therapy may be meaningful especially for older patients and patients who are not eligible for standard revascularization.

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Section: Evidence Of Ozone Therapy Effectiveness In Clinical Trialsmentioning

confidence: 67%

Section: Evidence Of Ozone Therapy Effectiveness In Clinical Trialsmentioning

confidence: 99%

Oxygen-Ozone (O2-O3) Therapy in Peripheral Arterial Disease (PAD): A Review Study

Juchniewicz

Lubkowska

2020

TCRM

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“…Among all the included 12 articles with 1055 participants, the publishing dates ranged from 2005 to 2020. Involved wound types include second‐ or third‐degree actinic ulcers following a radiotherapy cycle, 25 chronic venous leg ulcers, 28,33 digital ulcers (DUs) in systemic sclerosis (SSc), 32 critical limb ischemia (CLI), 24 and diabetic foot ulcers 11,15,26,27,29‐31 . The proportion of participants with completely healed wounds were reported in seven trials 11,15,26,28,29,32,33 .…”

Section: Resultsmentioning

confidence: 99%

“…In three studies, 25,26,31 the intervention period was until the complete healing of wounds, 20 days in four studies, 11,15,27,32 30 days in one study, 33 3 weeks in one study, 30 12 weeks in one study, 29 and at least 22 weeks or until study completion in one trial 24 . One study for lower‐limb venous ulcers was conducted until wounds suitable for skin puncture 28 . The follow‐up time varied between trials.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of ozone therapy for treating chronically refractory wounds and ulcers

Wen

Wang

et al. 2021

International Wound Journal

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This study aims at evaluating the efficacy and safety of ozone therapy for chronic wounds. The Cochrane Library, PubMed, Ovid Embase, Web of Science, and Chinese Biomedical Literature Database were searched. Randomised controlled trials (RCTs) about participants with chronic wounds were included. Risk of bias assessment was performed by the Cochrane risk-of-bias tool. A randomised-effects model was applied to pool results according to the types of wounds or ulcers. Among 12 included studies, ozone was implemented by topical application (ozone gas bath, ozonated oil, ozone water flushing) and systematic applications including autologous blood immunomodulation and rectal insufflation. The results indicated compared with standard control therapy for diabetic foot ulcers, ozone therapy regardless of monotherapy or combined control treatment markedly accelerated the improvement of the wound area(standardised mean difference(SMD) = 66.54%, 95% confidence interval (CI) = [46.18,86.90], P < .00001) and reduced the amputation rate (risk ration (RR) = 0.36, 95% CI = [0.24,0.54], P < .00001). But there is no improvement in the proportion of participants with completely healed wounds and length of hospital stay. No adverse events associated with ozone treatment have been reported. And the efficacy of ozone therapy for other wound types is still uncertain because of no sufficient studies. More high-quality randomised controlled trials are needed to confirm the efficacy and safety of ozone therapy for chronic wounds or ulcers.

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“…There were 11 articles comprising a total sampling size of 1145 patients with lower limb varicosity meeting all inclusion and exclusion criteria, and then were included in this meta‐analysis. The sample sizes of these studies vary from 40 to 173.…”

Section: Resultsmentioning

confidence: 99%

Comparison of endovenous laser treatment and high ligation in treatment of limb varicosity: A meta‐analysis

Cao

Wang

et al. 2019

International Wound Journal

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To assess the efficacy and safety of endovenous laser treatment (EVLT) and high ligation (HL) for limb varicosity using meta‐analysis. Multiple databases including PubMed, Springer, Excerpta Medica Database, Ovid Technologies, and China Journal Full‐text database were searched for relevant studies in English or Chinese, and full‐text articles were used to compare EVLT and HL for limb varicosity. Review Manager 5.0 was used to estimate the effects of the results among eligible articles. Forest plots, sensitivity analysis, and bias analysis of the included articles were also conducted. Initial screening yielded 1031 studies, 11 randomised controlled trials involving 1145 limb varicosity patients met the inclusion criteria in this study. The results of the heterogeneity test suggested that intraoperative blood loss mean difference (MD) = −6.31[−9.03, −3.60], P < 0.00001), operative time (MD) = −39.76[−42.27, −37.24], P < 0.00001), rate of complications (odds ratio [OR] = 0.37[0.22, 0.61], P < 0.0001), and recurrence (OR = 0.28[0.16, 0.49], P < 0.0001) were significantly different. Although both EVLT and HL have their own merits and demerits, EVLT is a more effective and safe method to treat limb varicosity.

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Ozone Gas Bath Combined with Endovenous Laser Therapy for Lower Limb Venous Ulcers: A Randomized Clinical Trial

Abstract: Ozone gas bath combined with EVLT showed improved efficacy for the treatment of lower limb venous ulcers and lower recurrence ratio comparison with EVLT alone. This procedure is a safe and technically feasible.

Cited by 9 publications

References 26 publications

<p>Oxygen-Ozone (O<sub>2</sub>-O<sub>3</sub>) Therapy in Peripheral Arterial Disease (PAD): A Review Study</p>

<p>Oxygen-Ozone (O<sub>2</sub>-O<sub>3</sub>) Therapy in Peripheral Arterial Disease (PAD): A Review Study</p>

A systematic review of ozone therapy for treating chronically refractory wounds and ulcers

Comparison of endovenous laser treatment and high ligation in treatment of limb varicosity: A meta‐analysis

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