The purpose of this study is to review the current knowledge of oxygen-ozone (O 2 -O 3 ) therapy and its effects on peripheral artery disease (PAD) risk factors, symptoms, as well as on PAD patients' quality of life. From the in vitro studies, it has been concluded that the oxygen-ozone therapy exerts a positive effect on the platelet aggregation, cell remodeling, cytoskeletal elements organization and mitochondria structure. In animal studies, it has been shown that the O 2 -O 3 therapy is an effective method in hypertension, and it diminishes the hypoxia state of various tissues. Clinical studies have provided evidence on the oxygenozone therapy effectiveness in low perfusion syndromes and hyperglycemia, as well as conditions with oxidative stress and inflammation. The oxygen-ozone therapy promotes faster recovery and enhances healing processes. It appears to be an effective adjunctive therapy in preventing peripheral artery disease complications such as occurrence of cardiovascular event, amputation or other extreme surgical solutions. It has been concluded that the O 2 -O 3 therapy improves the quality of life of PAD patients. The oxygen-ozone therapy appears to have no adverse events or side effects. Moreover, it is very cost-effective, as standard treatment costs can be reduced by 25%. Easy clinical protocols allow the implementation of oxygen-ozone therapy into the usual care of PAD patients. Finally, the O 2 -O 3 therapy may be meaningful especially for older patients and patients who are not eligible for standard revascularization.
The basic handball technique training for beginners must be in accordance with the physical condition of the player. The intensity and frequency of the exercises are determined precisely so that the exercises are effective and efficient. This research focuses on appropriate training programs so that optimal training results. The target of this research is in the form of training instruments / training programs and research results are published in reputable international journals. The research method used is research and development. The product developed in this research and development refers to the training program that is expected to be a reference in the implementation of basic handball technical training for beginners. From the results of the study, the training program for handball games has a validity of 0.87 so that it can be concluded that the training program for the adequacy of the basic handball technique is effectively used for the beginner athlete training program. Besides that, the training program for the adequacy of basic handball techniques is very much in accordance with the characteristics, growth, development of learners and beginner athletes and is able to make students easier to learn the basic techniques of handball games. The results of the measurement exercise, passing exercises performed 126 times, dribbling exercises performed 238 times, and shooting exercises were carried out 125 times.
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