Maximizing Patient Recruitment and Retention in a Secondary Stroke Prevention Clinical Trial: Lessons Learned from the STAND FIRM Study

Thayabaranathan, Tharshanah; Cadilhac, Dominique A.; Srikanth, Velandai; Fitzgerald, Sharyn M.; Evans, Roger G.; Gerraty, Richard; Phan, Thanh G.; Bladin, Christopher; Nelson, Mark; Frayne, Judith; Thrift, Amanda G.

doi:10.1016/j.jstrokecerebrovasdis.2016.02.020

Cited by 7 publications

(10 citation statements)

References 27 publications

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“…The degree of matching between researcher's language and patient's language influences compliance and retention [9,11,12,49,56,71,73,81,83,100,101,116,130,136,142,162,171] .…”

Section: Languagementioning

confidence: 99%

“…Patient with severe illness have higher compliance and retention than those with less severe illness. But they may also withdraw due to the worsening of their condition [17,24,31,33,36,47,48,56,57,59,64,70,72,78,81,93,97,102,105,109,119,123,134,135,136,140,146,150,151,156,157,161,170,172,173,178,179,182,185] 39/182 Types of diseases…”

Section: Lost or Stolen Drugsmentioning

confidence: 99%

“…The more complex the study protocol, the higher the compliance and retention [16,22,29,33,34,46,48,53,[56][57][58][61][62][63][64]66,71,72,72,81,82,112,114,117,119,124,125,141,147,149,152,172,180,187,189] 36/182 Frequency of follow-up T 1 Drug / Product Patients who are dissatisfied with drug/product (taste, smell, etc) have worse compliance and retention [14,17,18,22,31,54,57,64,71,74,78,83,87,92,97,…”

Section: T Rmentioning

confidence: 99%

“…Due to factors such as the treatment environment or the investigator, the compliance and retention of patients in different research sites also varies [14,20,38,40,56,101,115,118,121,144,161,166,169,177,182] 15/182 Feeling to be cured…”

Section: T Bmentioning

confidence: 99%

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How to improve participant compliance and retention in clinical trials：A Scoping Review

Yu¹,

Lin²,

Liang³

et al. 2020

Preprint

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Background: The reliability of results can be compromised when subsets of participants who remain on a study differ from those who drop out. Although recent studies have investigated strategies for improving compliance and retention , there has been very little investigation of process factors, regardless of the type of literature and the publication date. factors that may influence how and why compliance and retention may be successful (or not).Aim: To identify process factors that may influence participant compliance and retention in clinical trials, and potential strategies to improve the compliance and retention, from published studies, grey literature, and the reference lists of included articles to facilitate future design and implementation of trials.Methods : Six databases and two clinical trial registries were searched on November 29, 2019. Surveys, interviews, retrospective data analyses, theoretical research, reviews and clinical studies aiming at investigating factors and potential strategies were included. Data synthesis followed an iterative process to develop a list of process factors and potential retention strategies.Results were presented mainly as texts, including visualization using word cloud, and descriptive data.Results: 182 publications were included in this review, composed of 58 retrospective reflection of RCTs based on 1,132 clinical trials with 177804 participants, 27 implementation researches, 22 theoretical researches, 20 interviews, 18 surveys, 17 randomized controlled trials, 8 literature reviews, 5 systematic review and meta analysis, 3 mixed methods researches, 2 case report, 1 meta-ethnographic synthesis and 1 cohort study. We identified 70 process factors that may affect the compliance and retention . The most commonly addressed factors were age, education, economy, trust in clinical trials, supporting from surrounding people, safety concerns and effectiveness. We found 42 potential strategies to improve compliance and retention. Strategies reported most frequently were that researchers should pay attention to the changes on participants' psychological condition, try their best to build good relationships, provide some compensation and educate the participants about compliance and retention . Conclusion：These factors that may affect the compliance and retention can help researchers predict participants who are less likely to adhere and develop screening tools to find efficiently their suitable participants. These potential strategies that may improve the compliance and retention.

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“…The degree of matching between researcher's language and patient's language influences compliance and retention [9,11,12,49,56,71,73,81,83,100,101,116,130,136,142,162,171] .…”

Section: Languagementioning

confidence: 99%

Section: Lost or Stolen Drugsmentioning

confidence: 99%

Section: T Rmentioning

confidence: 99%

Section: T Bmentioning

confidence: 99%

See 2 more Smart Citations

How to improve participant compliance and retention in clinical trials：A Scoping Review

Yu¹,

Lin²,

Liang³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Not applicable JJ Jin2017 [50] Blood [56] Stroke No USA Nurse Interview 2 Not applicable Atherton P J2016 [57] Cancer public USA Adults Retrospective research from RCT 1640 14 RCTs HB Zhang2016 [58] Cancer No China Adults Retrospective research from RCT 36 1 RCT Miguel AQ2016 [59] Cocaine dependence Public Brazil Adults RCT 65 Not applicable…”

mentioning

confidence: 99%

How to improve participant compliance in clinical trials: A Scoping Review of process factors

Lin

Liang

et al. 2020

Preprint

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Background The reliability of results can be compromised when subsets of participants who remain on a study differ from those who drop out. Although recent studies have investigated approaches for improving compliance, there has been very little investigation of process factors, regardless of the type of literature and the publication date. factors that may influence how and why compliance may be successful (or not). Aim To identify process factors that may influence participant compliance retention in clinical trials, and potential approaches to improve the compliance, from published studies, to facilitate future design and implementation of trials. Methods Six databases and two clinical trial registries were searched on November 29, 2019. Surveys, interviews, retrospective data analyses, theoretical research, reviews and clinical studies aiming at investigating factors influencing participant compliance and potential approaches for improving compliance retention were included. Data synthesis followed an iterative process to develop a list of process factors and potential retention approaches. Results were analysed descriptively, including visualization using word cloud. Results 181 publications were included in this review, composed of 58 retrospective analysis of RCTs based on 1,132 clinical trials with 177804 participants, 27 implementation researches, 22 theoretical researches, 20 interviews, 18 surveys, 17 randomized controlled trials, 8 literature reviews, 5 systematic review and meta analysis, 3 mixed methods researches, 2 case report and 1 cohort study. We identified 70 process factors that may affect the compliance. The most commonly addressed factors were age, education, economy, trust in clinical trials, supporting from surrounding people, safety concerns and effectiveness. We found 44 potential approaches to improve compliance. Approaches reported most frequently were that researchers should pay attention to the changes on participants' psychological condition, try their best to build good relationships, provide some compensation and educate the participants about compliance. Conclusion These factors that may affect the compliance can help researchers predict participants who are less likely to adhere and develop screening tools to find efficiently their suitable participants. These potential approaches that may improve the compliance provide suggestions for improving compliance.

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Quality of life after stroke: a longitudinal analysis of a cluster randomized trial

et al. 2022

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Maximizing Patient Recruitment and Retention in a Secondary Stroke Prevention Clinical Trial: Lessons Learned from the STAND FIRM Study

Cited by 7 publications

References 27 publications

How to improve participant compliance and retention in clinical trials：A Scoping Review

How to improve participant compliance and retention in clinical trials：A Scoping Review

How to improve participant compliance in clinical trials: A Scoping Review of process factors

Quality of life after stroke: a longitudinal analysis of a cluster randomized trial

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Maximizing Patient Recruitment and Retention in a Secondary Stroke Prevention Clinical Trial: Lessons Learned from the STAND FIRM Study

Cited by 7 publications

References 27 publications

How to improve participant compliance and retention in clinical trials：A Scoping Review

How to improve participant compliance and retention in clinical trials：A Scoping Review

How to improve&nbsp;participant compliance&nbsp;in clinical trials: A Scoping Review of process factors

Quality of life after stroke: a longitudinal analysis of a cluster randomized trial

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How to improve participant compliance in clinical trials: A Scoping Review of process factors