Altered expression of ATP-sensitive K+ channels in Hirschsprung's disease

Laparoscopic-assisted pull-through operation for Hirschsprung’s disease: a systematic review and meta-analysis

“…However, the variable rates of HAEC may also relate to inconsistent definitions between studies. The pathogenesis of HAEC is complex and poorly understood; faecal stasis, along with impaired immunity, epithelial barrier dysfunction and an abnormal microbiota, is the main etiology for HAEC [21,23,24]. In the present data, patients in the Soave and Duhamel groups also suffered from constipation, which could be an indicator for faecal stasis, thus contributing to the development of HAEC.…”

“…Forty-three (8.4 %) patients with HD in the present meta-analysis required further secondary procedures after the first pull-through, reflecting the complexity of surgery for this disease. Recent studies suggest that the ganglionic bowel in patients with HD has abnormalities in innervation, further complicating the management of HD [23,24,[27][28][29][30]. However, only a very few complications due to laparoscopy such as perforation of the colon, division of the ureter or bladder perforation occurred, which makes the laparoscopic approach a safe addendum in the pull-through procedure.…”

ATP‐Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles

“…There may be some variations in specific smooth muscles. For example, in the urethra there is evidence for expression of Kir6.2 and of heteromultimer formation(525) and both pore-forming subunits may also be expressed in the colonic smooth muscle(536).In general less is known of the physiological role of these channels in these varied organ systems and they have been little studied in the various genetically modified mouselines. The application of K ATP channel openers and inhibitors often causes relaxation and contraction respectively of the smooth muscle and thus it is clear these currents are of sufficient density to have the potential to significantly modify organ function (284; 371; 523).…”

Altered expression of a two-pore domain (K2P) mechano-gated potassium channel TREK-1 in Hirschsprung’s disease

“…Changes in the the colonic epithelium have been postulated as a causative factor in the development of HAEC through pertubations in structure and function of the epithelial lining (29). Recently, we showed that ATP-sensitive K + -channel (K (ATP) ) subunits are which colocalized with TJ-proteins were reduced in Hirschsprung's specimens (30). These findings implicate an intrinsic deficiency of K + channels, in the development of HAEC.…”