Spatial Organization of Epigenomes

Abstract

The role of genome architecture in transcription regulation has become the focus of an increasing number of studies over the past decade. Chromatin organization can have a significant impact on gene expression by promoting or restricting the physical proximity between regulatory DNA elements. Given that any change in chromatin state has the potential to alter DNA folding and the proximity between control elements, the spatial organization of chromatin is inherently linked to its molecular composition. In this review, we explore how modulators of chromatin state and organization might keep gene expression in check. We discuss recent findings and present some of the less well-studied aspects of spatial genome organization such as chromatin dynamics and regulation by non-coding RNAs.

Cytoskeletal Configuration Modulates Mechanically Induced Changes in Mesenchymal Stem Cell Osteogenesis, Morphology, and Stiffness

“…The cell nucleus is mechanically integrated into the cell architecture 48 and participates in mechanosensing and fate selection of MSCs 49 . The physical coupling between the nucleus and cytoskeleton is facilitated via the LINC complex 32 50 , comprising Nesprin and Sun proteins 50 that enable the sensing of LIV 13 .…”