Associations Between Methylenetetrahydrofolate Reductase Polymorphisms, Serum Homocysteine Levels, and Incident Cortical Cataract

A Vegetarian Diet Is Associated with a Lower Risk of Cataract, Particularly Among Individuals with Overweight: A Prospective Study

“…These findings contrast that of the Blue Mountains Eye Study, in which both serum homocysteine elevation and methylenetetrahydrofolate reductase C677T polymorphism (CT/TT vs CC-polymorphisms that influence homocysteine level) were associated with a higher risk of cortical cataracts. 19 The findings from this current study suggest that the potential benefits of vegetarian diets might outweigh the risk related to homocysteine. Unfortunately, in both the EPIC-Oxford and this current study, only a limited number of participants had plasma homocysteine available, 26,27 precluding further analysis on how homocysteine might influence cataract risk in vegetarians.…”

“…18 Hyperhomocysteinemia has been associated with a higher risk of cortical cataract in the Blue Mountains Eye Study through both a cohort and a Mendelian randomization design. 19 Whether the benefits of vegetarian diets outweigh the risk in terms of cataract incidence deserves more investigations. So far, published findings on the association between vegetarian diets and cataracts are limited and inconsistent; vegetarian diets are associated with a lower incidence of cataracts in the EPIC-Oxford Cohort, 20 but a higher prevalence of cataracts in an Asian Community in Leicester, UK.…”

Arterial Hypertension and Methylenetetrahydrofolate Reductase C677T Gene Polymorphism

“…Ген MTHFR кодирует аминокислотную последовательность фермента, играющего ключевую роль в метаболизме фолиевой кислоты, который преобразует 5,10-метилентетрагидрофолат в 5-метилтетрагидрофолат, активную форму фолатов, и участвует в превращении гомоцистеина в метионин. Плейотропное влияние гена MTHFR описано более чем в 2 900 научных публикациях, полиморфизмы ассоциируются с сердечно-сосудистыми заболеваниями (ССЗ), ишемическими инсультами, болезнью Паркинсона, дефектами развития нервной трубки плода, онкологическими заболеваниями, осложнениями беременности и офтальмологической патологией (глаукома, катаракта, диабетическая ретинопатия) [1][2][3]. Одним из наиболее изученных полиморфизмов гена MTHFR, влияющим на активность фермента, является вариант, в котором нуклеотид цитозин (C) в позиции 677 заменен тимином (T).…”

Effect of Seamless Nursing for Complications on Cataract Patients

“…In treatment process, we collected the complication data of patients, the complications included endothelial edema, intraocular hypertension and hyphema. In addition, the patients would complete Self-Rating Anxiety Scale (SAS) and Self-rating depression scale (SDS), they provided the anxiety information and depression information to our study [10,11,12]. Furthermore, The cutoff score of SAS is 50, 50-59 for mild anxiety, 60-69 for moderate anxiety, and 70 or more for severe anxiety.…”