Comparative physiogenomic analyses of weight loss in response to 2 modes of bariatric surgery: demonstration with candidate neuropsychiatric and cardiometabolic genes

Good weight loss responders and poor weight loss responders after Roux-en-Y gastric bypass: clinical and nutritional profiles

“…Polymorphisms in genes related to RYGB response after 1 year post-surgery were identified (24). Several common genetic variants may influence weight loss results after RYGB as shown by Rinella et al (25) when compared genetic polymorphisms between patients with lower and higher %EWL.…”

Polygenic risk score for predicting weight loss after bariatric surgery

“…on a relatively large and straightforward sample of genetic variants, we selected SNPs previously associated to BMI in prior GWAS and meta-analyses. Regarding the type of surgery, Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding stand among the most extensively studied (16,17). In the present study, we focused on biliopancreatic diversion with duodenal switch, a surgery recognized for its particular effectiveness in inducing durable weight loss and metabolic improvements, including type 2 diabetes remission and lipid profile normalization (18,19).…”

Bariatric Surgery and Precision Nutrition

“…Two SNPs in the UCP2 gene (Ala55Pro and −866G > A) are considered as biomarkers of weight loss after bariatric surgery [ 22 ]. When Seip et al (2016) [ 26 ] evaluated 330 SNPs of genes involved in metabolic regulation they identified many genes that could be potential markers to discriminate changes in body mass index (BMI) one year after surgical intervention (LAGB or RYGB). Other authors suggested that polymorphisms, like the SNP of the preproghrelin gene (rs696217), could mark a successful weight loss outcome [ 27 ].…”