Bile acids synthesis decreases after laparoscopic sleeve gastrectomy

Escalona, Alex; Muñóz, Rodrigo; Irribarra, Verónica; Solari, Sandra; Allende, Fidel; Poblete, Juan Francisco Miquel

doi:10.1016/j.soard.2015.11.015

Cited by 25 publications

(15 citation statements)

References 45 publications

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“…This sequential rise of BA and FGF19 lends support to the concept that postprandial elevation of BAs (such as CDCA) trigger FGF19 release. This is consistent with the existing literature . The positive metabolic effects of FGF19 have been reported in murine studies including increased metabolic rate , improved weight loss and glucose metabolism , and resistance to diet induced obesity .…”

Section: Discussionsupporting

confidence: 92%

Fibroblast growth factor 21 correlates with weight loss after vertical sleeve gastrectomy in adolescents

Khan

Shaw

Zhang

et al. 2016

Obesity

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Objective Vertical sleeve gastrectomy (VSG) results in weight loss, increased bile acids (BA) and fibroblast growth factor 19 (FGF19) levels. FGF21 shares essential co-factors with FGF19 but its physiology early post-VSG has not been assessed. Methods Ten adolescents (17.4 ± 0.5 years and BMI 51.5 ± 2.5 kg/m2) were enrolled. Fasting and post-meal (100 mL Ensure™) samples (0–120 min) were collected (Pre-VSG [V1], 1 [V2], & 3 months [V3] post-VSG) for analysis of BA, FGF19, and FGF21. Results Post-VSG subjects lost weight (V2 11.8 ± 0.8 kg; V3 21.9 ± 1.7 kg). BA and FGF19 increased by V2; 143.6% at 30 min and 74.9% at 90 min postmeal, respectively. BA hydrophobicity index also improved by V3; 21.1% at 30 min postmeal. Interestingly, fasting and 120 min postmeal FGF21 levels at V2 were increased by 135.7% and 253.9% respectively, but then returned to baseline at V3. BA levels correlated with FGF21 at V2 (P = 0.003, r = 0.89) and body weight lost post-VSG correlated with FGF21 levels (V2; P = 0.012, R = 0.82). Conclusion Expected changes were seen in BA and FGF19 biology after VSG in adolescents, but novel changes were seen in correlation between the early postsurgical increase in FGF21 and weight loss, suggesting that FGF21 may play a role in energy balance postoperatively and further investigation was warranted.

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Section: Discussionsupporting

confidence: 92%

Fibroblast growth factor 21 correlates with weight loss after vertical sleeve gastrectomy in adolescents

Khan

Shaw

Zhang

et al. 2016

Obesity

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“…We found significantly higher serum BA levels in patients with cholecystectomy compared to patients with the gall bladder in situ 5 years after surgery. This may, completely or partly, be attributable to increased cycling of the BA pool in the enterohepatic circulation due to lack of storage capacity [39,40].…”

Section: Discussionmentioning

confidence: 99%

Bile acid profiles over 5 years after gastric bypass and duodenal switch: results from a randomized clinical trial

Risstad

Kristinsson

Fagerland

et al. 2017

Surgery for Obesity and Related Diseases

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(2017). Bile acid profiles over 5 years following gastric bypass and duodenal switch -Results from a randomized clinical trial. Surgery for obesity and related diseases. https://doi.org/10.1016/j.soard.2017.05.024Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections. General rightsCopyright and moral rights for the publications made accessible in the Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognize and abide by the legal requirements associated with these rights.•Users may download and print one copy of any publication from the Research Portal for the purpose of private study or research.•You may not further distribute the material or use it for any profit-making activity or commercial gain •You may freely distribute the URL identifying the publication in the Research Portal Take down policy If you believe that this document breaches copyright please contact librarypure@kcl.ac.uk providing details, and we will remove access to the work immediately and investigate your claim. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…In large part, human studies have confirmed that fasting or postprandial total bile acid concentrations are increased following RYGB (Ahmad et al, 2013; Albaugh et al, 2015; De Giorgi et al, 2015; Ferrannini et al, 2015; Gerhard et al, 2013; Jahansouz et al, 2016; Jørgensen et al, 2015; Nakatani et al, 2009; Pournaras et al, 2012; Simonen et al, 2012; Steinert et al, 2013; Werling et al, 2013b) and BPD (Ferrannini et al, 2015; Nakatani et al, 2009). The effects of VSG on bile acid levels is mixed with some showing increased plasma concentrations (Jahansouz et al, 2016; Khan et al, 2016; Steinert et al, 2013), but others detecting no change (Belgaumkar et al, 2016; Escalona et al, 2016; Nakatani et al, 2009). As expected, studies examining adjustable gastric banding, known to be an exclusively restrictive procedure, show no changes in circulating bile acids (Kohli et al, 2013a; Pournaras et al, 2012).…”

Section: Bile Acids and Obesitymentioning

confidence: 99%

Bile acids and bariatric surgery

Albaugh

Banan

Ajouz

et al. 2017

Molecular Aspects of Medicine

103

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Bariatric surgery, specifically Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG), are the most effective and durable treatments for morbid obesity and potentially a viable treatment for type 2 diabetes (T2D). The resolution rate of T2D following these procedures is between 40-80% and far surpasses that achieved by medical management alone. The molecular basis for this improvement is not entirely understood, but has been attributed in part to the altered enterohepatic circulation of bile acids. In this review we highlight how bile acids potentially contribute to improved lipid and glucose homeostasis, insulin sensitivity and energy expenditure after these procedures. The impact of altered bile acid levels in enterohepatic circulation is also associated with changes in gut microflora, which may further contribute to some of these beneficial effects. We highlight the beneficial effects of experimental surgical procedures in rodents that alter bile secretory flow without gastric restriction or altering nutrient flow. This information suggests a role for bile acids beyond dietary fat emulsification in altering whole body glucose and lipid metabolism strongly, and also suggests emerging roles for the activation of the bile acid receptors farnesoid x receptor (FXR) and G-protein coupled bile acid receptor (TGR5) in these improvements. The limitations of rodent studies and the current state of our understanding is reviewed and the potential effects of bile acids mediating the short-and long-term metabolic improvements after bariatric surgery is critically examined.

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Bile acids synthesis decreases after laparoscopic sleeve gastrectomy

Cited by 25 publications

References 45 publications

Fibroblast growth factor 21 correlates with weight loss after vertical sleeve gastrectomy in adolescents

Fibroblast growth factor 21 correlates with weight loss after vertical sleeve gastrectomy in adolescents

Bile acid profiles over 5 years after gastric bypass and duodenal switch: results from a randomized clinical trial

Bile acids and bariatric surgery

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