Fibroblast growth factor 21 correlates with weight loss after vertical sleeve gastrectomy in adolescents

Khan, Farooq; Shaw, Lindsey N.; Zhang, Wujuan; Gonzalez, Rosa Maria Salazar; Mowery, Sarah; Oehrle, Melissa; Zhao, Xueheng; Jenkins, Todd M.; Setchell, Kenneth D.R.; Inge, Thomas H.; Kohli, Rohit

doi:10.1002/oby.21658

Cited by 35 publications

(19 citation statements)

References 31 publications

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“…In large part, human studies have confirmed that fasting or postprandial total bile acid concentrations are increased following RYGB (Ahmad et al, 2013; Albaugh et al, 2015; De Giorgi et al, 2015; Ferrannini et al, 2015; Gerhard et al, 2013; Jahansouz et al, 2016; Jørgensen et al, 2015; Nakatani et al, 2009; Pournaras et al, 2012; Simonen et al, 2012; Steinert et al, 2013; Werling et al, 2013b) and BPD (Ferrannini et al, 2015; Nakatani et al, 2009). The effects of VSG on bile acid levels is mixed with some showing increased plasma concentrations (Jahansouz et al, 2016; Khan et al, 2016; Steinert et al, 2013), but others detecting no change (Belgaumkar et al, 2016; Escalona et al, 2016; Nakatani et al, 2009). As expected, studies examining adjustable gastric banding, known to be an exclusively restrictive procedure, show no changes in circulating bile acids (Kohli et al, 2013a; Pournaras et al, 2012).…”

Section: Bile Acids and Obesitymentioning

confidence: 99%

Bile acids and bariatric surgery

Albaugh

Banan

Ajouz

et al. 2017

Molecular Aspects of Medicine

104

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Bariatric surgery, specifically Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG), are the most effective and durable treatments for morbid obesity and potentially a viable treatment for type 2 diabetes (T2D). The resolution rate of T2D following these procedures is between 40-80% and far surpasses that achieved by medical management alone. The molecular basis for this improvement is not entirely understood, but has been attributed in part to the altered enterohepatic circulation of bile acids. In this review we highlight how bile acids potentially contribute to improved lipid and glucose homeostasis, insulin sensitivity and energy expenditure after these procedures. The impact of altered bile acid levels in enterohepatic circulation is also associated with changes in gut microflora, which may further contribute to some of these beneficial effects. We highlight the beneficial effects of experimental surgical procedures in rodents that alter bile secretory flow without gastric restriction or altering nutrient flow. This information suggests a role for bile acids beyond dietary fat emulsification in altering whole body glucose and lipid metabolism strongly, and also suggests emerging roles for the activation of the bile acid receptors farnesoid x receptor (FXR) and G-protein coupled bile acid receptor (TGR5) in these improvements. The limitations of rodent studies and the current state of our understanding is reviewed and the potential effects of bile acids mediating the short-and long-term metabolic improvements after bariatric surgery is critically examined.

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Section: Bile Acids and Obesitymentioning

confidence: 99%

Bile acids and bariatric surgery

Albaugh

Banan

Ajouz

et al. 2017

Molecular Aspects of Medicine

104

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“…Following SG, data are less consistent. Some researchers showed increased [13,29,30] or decreased [31] levels, whereas others showed transiently decreased [40] or unchanged [17,32,33] levels at different time points after surgery associated, or not, with metabolic improvements (Table 3). Still, the question arises if there is an acute change at one week and one month after surgery and if this change is related or not to the improvement of IR.…”

Section: Discussionmentioning

confidence: 99%

“…However, while circulating BAs have been demonstrated to increase following RYGB [13,18,[26][27][28], the effect of SG on BA has shown mixed results. Namely, some authors reported increased concentrations [13,29,30], others decreased [31] circulating levels of BA, and finally, others detected no change after SG [32,33]. Most importantly, the exact timing of the BA changes and their potential role in the reduction of IR and restauration of insulin sensitivity are not fully elucidated [3,11,34].…”

Section: Introductionmentioning

confidence: 99%

Ultra-Early and Early Changes in Bile Acids and Insulin after Sleeve Gastrectomy among Obese Patients

et al. 2019

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Background and Objective: In obese patients, sleeve gastrectomy (SG) has shown mixed results on bile acid (BA) values. The aim of our study was to examine the potential ultra-early and early changes of the circulating total BA in relation with the changes of insulin resistance (IR) in obese patients submitted to laparoscopic SG. Materials and Methods: Twenty-four obese subjects were investigated for body mass index (BMI), total fasting BA, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and leptin before and at 7 and 30 d after SG. Results: After surgery, mean BMI decreased at the first (p < 0.001) and at the second time point (p < 0.001) relative to baseline. Total fasting BA values did not change significantly at 7 d (p = 0.938) and at 30 d (p = 0.289) after SG. No significant changes were found at 7 d (p = 0.194, p = 0.34) and 30 d (p = 0.329, p = 0.151) after surgery regarding fasting insulin and HOMA-IR, respectively. However, a trend of increased total fasting BA and decreased fasting insulin and HOMA- after laparoscopic SG has been found. Negative correlations between total fasting BA and insulin (r = −0.807, p = 0.009), HOMA-IR (r = −0.855, p = 0.014), and blood glucose (r = −0.761, p = 0.047), respectively, were observed at one month after SG. Conclusion: In conclusion, here, we found a lack of significant changes in total fasting BA, insulin, and HOMA-IR ultra-early and early after SG, which precluded us to consider a possible relation between the variations of BA and IR. However, the presence of the tendency for total fasting BA to increase and for insulin and HOMA-IR to decrease, as well as of the negative correlations one month after laparoscopic SG, suggest that this surgery brings about some changes that point towards the existence, and possibly towards the restoration, at least to some extent, of the link between BA and glucose metabolism.

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“…These murine data are, however, contrary to previous human work, wherein use of a luminal bile acid-binding resin, colesevelam (a bile acid sequestrant), was reported to produce increased hepatic steatosis by magnetic resonance evaluation 21 . Further, multiple authors have shown that obese individuals have lower circulating serum bile acid levels and an impaired post-prandial bile acid and FGF19 response 22 . The circulating bile acid level and post-prandial responses of FGF19 and bile acids are both corrected with surgically induced weight loss (e.g.…”

Section: Inhibition and Importance Of Normal Bile Acid Enterohepatic mentioning

confidence: 99%

Bile acid metabolism and signaling: potential therapeutic target for nonalcoholic fatty liver disease

Lin

Kohli

2018

Clinical and Translational Gastroenterology

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Fibroblast growth factor 21 correlates with weight loss after vertical sleeve gastrectomy in adolescents

Cited by 35 publications

References 31 publications

Bile acids and bariatric surgery

Bile acids and bariatric surgery

Ultra-Early and Early Changes in Bile Acids and Insulin after Sleeve Gastrectomy among Obese Patients

Bile acid metabolism and signaling: potential therapeutic target for nonalcoholic fatty liver disease

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