Determination of propofol glucuronide from hair sample by using mixed mode anion exchange cartridge and liquid chromatography tandem mass spectrometry

Kwak, Jae‐Hwan; Kim, Hye Kyung; Choe, Sanggil; In, Sangwhan; Pyo, Jae Sung

doi:10.1016/j.jchromb.2016.01.061

Cited by 10 publications

(1 citation statement)

References 13 publications

(21 reference statements)

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“…To date, many studies have been conducted for the determination of PRO in biological fluids such as blood and urine. These studies include analytical methodologies such as spectrophotometric 5 , high-performance liquid chromatography (HPLC), [6][7][8][9] gas chromatography-mass spectrometry (GC-MS), 10,11 liquid chromatography-mass spectrometry (LC-MS), [12][13][14][15][16][17][18][19] and capillary electrophoresis. 20 However, there are a limited number of studies on the electrochemical analysis of PRO in the scientific literature.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric quantification of the anesthetic drug propofol (2,6-diisopropylphenol) in the pharmaceutical formulations on a boron-doped diamond electrode

et al. 2021

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In this paper, the detailed electrochemistry of propofol (PRO) which is one of the intravenous agents commonly used for sedative-hypnotic purposes was examined. In cyclic voltammetry, the agent showed one irreversible and diffusion?controlled oxidation peak, resulting in the formation of a couple with a reduction and re-oxidation wave at less positive potentials. The effect of electrode pretreatment procedures on the electrochemical response of PRO was investigated by using square wave voltammetry (SWV) and the optimum procedure was used to improve the signal response in subsequent studies. Quantification of PRO was done based on the first oxidation peak using SWV. After optimization of all variables, the linear working range of PRO was found to be between 2.5 ?g mL-1 (1.4?10-5 mol L-1) and 160.0 ?g mL-1 (1.1?10-3 mol L-1, n=15) with a detection limit 0.71 ?g mL-1 (3.9?10-6 mol L-1). No noteworthy interference effect was detected. Also, the developed method was used for quantification of PRO in pharmaceutical sample.

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Section: Introductionmentioning

confidence: 99%

Voltammetric quantification of the anesthetic drug propofol (2,6-diisopropylphenol) in the pharmaceutical formulations on a boron-doped diamond electrode

et al. 2021

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Smart Materials for Solid‐Phase Extraction Applications

Carrasco-Correa

Vergara-Barberán

Herrero‐Martínez

2019

Handbook of Smart Materials in Analytical Chemistry

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First derivative synchronous spectrofluorimetric method for the simultaneous determination of propofol and cisatracurium besylate in biological fluids

et al. 2019

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Propofol and cisatracurium besylate have been simultaneously determined using a highly sensitive first derivative synchronous spectrofluorometric method. The method is based on measuring first derivative synchronous spectrofluorimetric amplitude at Δλ = 40 nm with a scanning rate of 600 nm/min. The different experimental parameters affecting the fluorescence intensity of the two drugs were carefully studied and optimized. The amplitude–concentration plots were rectilinear over the range 40.0–400.0 ng/mL and 20.0–280.0 ng/mL for propofol and cisatracurium, respectively with lower detection limits of 4.0 and 2.35 ng/mL and quantification limits of 12.1 and 7.1 ng/mL for propofol and cisatracurium, respectively. The proposed method was successfully applied for the determination of the two compounds in synthetic mixtures and in commercial ampoules. The high sensitivity attained using the proposed method allowed the simultaneous determination of both drugs in spiked plasma samples. The mean % recoveries in spiked human plasma (n = 3) were 96.53 ± 0.90 and 96.20 ± 1.64 for each of propofol and cisatracurium, respectively. The method was validated in compliance with International Council of Harmonization (ICH) Guidelines.

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Determination of propofol glucuronide from hair sample by using mixed mode anion exchange cartridge and liquid chromatography tandem mass spectrometry

Cited by 10 publications

References 13 publications

Voltammetric quantification of the anesthetic drug propofol (2,6-diisopropylphenol) in the pharmaceutical formulations on a boron-doped diamond electrode

Voltammetric quantification of the anesthetic drug propofol (2,6-diisopropylphenol) in the pharmaceutical formulations on a boron-doped diamond electrode

Smart Materials for Solid‐Phase Extraction Applications

First derivative synchronous spectrofluorimetric method for the simultaneous determination of propofol and cisatracurium besylate in biological fluids

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