Voltammetric quantification of the anesthetic drug propofol (2,6-diisopropylphenol) in the pharmaceutical formulations on a boron-doped diamond electrode

Abstract

In this paper, the detailed electrochemistry of propofol (PRO) which is one of the intravenous agents commonly used for sedative-hypnotic purposes was examined. In cyclic voltammetry, the agent showed one irreversible and diffusion?controlled oxidation peak, resulting in the formation of a couple with a reduction and re-oxidation wave at less positive potentials. The effect of electrode pretreatment procedures on the electrochemical response of PRO was investigated by using square wave voltammetry (SWV) and the optimum procedure was used to improve the signal response in subsequent studies. Quantification of PRO was done based on the first oxidation peak using SWV. After optimization of all variables, the linear working range of PRO was found to be between 2.5 ?g mL-1 (1.4?10-5 mol L-1) and 160.0 ?g mL-1 (1.1?10-3 mol L-1, n=15) with a detection limit 0.71 ?g mL-1 (3.9?10-6 mol L-1). No noteworthy interference effect was detected. Also, the developed method was used for quantification of PRO in pharmaceutical sample.

Electrochemical Determination of Flavonoid Fisetin in Commercial Dietary Supplements Using a Boron‐Doped Diamond Electrode

“…[25] On the other hand, the analytical performance of this electrode may vary depending on the boron doping level, [26] surface morphology and presence of impurities, surface tip, and applied anodic or cathodic pretreatment steps. [25,[27][28][29][30] Our research group has conducted much research using the BDD electrode in the electrochemical analysis of drugs [31][32][33][34] and some polyphenolic compounds. [35,36] This paper is the first study to elucidate the electrochemical oxidation behavior of the flavonoid FST using BDD electrode surface.…”