Anti-inflammatory neolignans from the roots of Magnolia officinalis

Shih, Hung Cheng; Kuo, Ping Chung; Wu, Shwu Jen; Hwang, Tsong‐Long; Hung, Hsin Yi; Shen, De Yang; Shieh, Po Chuen; Liao, Yu-Hsien; Lee, E-Jian; Gu, Qiong; Lee, Kuo Hsiung̀; Wu, Tong

doi:10.1016/j.bmc.2016.01.049

Cited by 20 publications

(8 citation statements)

References 33 publications

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“…Pharmacological studies have indicated that M. officinalis has antioxidative, antispasmodic, anticancer, and antidiabetic activities [12, 13]. In traditional Chinese medicine, the roots, stems, and branches of M. officinalis have been used for treating cough, asthma, liver disease, and diarrhea [14]. Furthermore, M. officinalis has shown potential antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), which is a common cause of multidrug-resistant infections with considerably high mortality rates [15].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Tyrosinase Inhibitory, Antioxidant, Antimicrobial, and Antiaging Activities of Magnolia officinalis Extracts after Aspergillus niger Fermentation

Chen

Cheng

et al. 2018

BioMed Research International

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This study intended to improve physiological characteristics of Magnolia officinalis bark (MOB) extracts by Aspergillus niger fermentation. M. officinalis bark was extracted using distilled water, 95% ethanol, and methanol, and it was then fermented by A. niger. The physiological characteristics of the fermented extracts, namely, tyrosinase inhibitory activity, antioxidant activity, antibacterial activity, and anti-skin-aging activity, were evaluated and compared with those of unfermented extracts. To determine the safety of the fermented extracts, their cytotoxicity was analyzed by measuring the cell viability of CCD-966SK and human epidermal melanocytes (HEMn) after exposure. The fermented methanol extract exhibited the highest antityrosinase activity, total phenolic content, and antioxidant activity. The total phenolic content of the extracts fermented by A. niger was 3.52 times greater than that of the unfermented extracts. The optimal IC50 values for tyrosinase inhibition and 2,2-diphenyl-1-picrylhydrazyl (DPPH) removal by the A. niger-fermented extracts were 30 and 12 μg/mL, respectively. The fermented methanol extracts inhibited skin-aging-related enzymes such as collagenase, elastase, MMP-1, and MMP-2. Compared with the unfermented extracts, the fermented extracts also contained greater antibacterial activity against tested stains including MRSA. These results could be attributed to an increase in the concentration of original active compounds and the biosynthesis of new compounds during fermentation. In cytotoxicity assays, the A. niger-fermented extracts were nontoxic to CCD-966SK cells, even at 500 μg/mL. Hence, in general, methanol-extracted M. officinalis fermented by A. niger for 72 h has the most active antioxidant, skincare, or antiaging compounds for healthy food or cosmetics applications.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Tyrosinase Inhibitory, Antioxidant, Antimicrobial, and Antiaging Activities of Magnolia officinalis Extracts after Aspergillus niger Fermentation

Chen

Cheng

et al. 2018

BioMed Research International

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“…Coumarins also were found to have anti-inflammatory activity by inhibiting different inflammatory mediators such as cyclooxygenase-2, nitric oxide, tumor necrosis factor- α and interleukins [ 77 – 79 ]. Neolignans were reported to exert anti-inflammatory effects by suppressing superoxide anion generation and elastase release [ 80 ], they also exhibited nitric oxide (NO) and tumor necrosis factor-α (TNF-α) inhibitory effects [ 81 ]. However, according to our results, only scopoletin ( 4 ) exerted mild inhibition of elastase release.…”

Section: Discussionmentioning

confidence: 99%

Study of the anti-allergic and anti-inflammatory activity of Brachychiton rupestris and Brachychiton discolor leaves (Malvaceae) using in vitro models

Thabet

Youssef

Korinek

et al. 2018

BMC Complement Altern Med

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BackgroundBrachychiton rupestris and Brachychiton discolor (Malvaceae) are ornamental trees native to Australia. Some members of Brachychiton and its highly related genus, Sterculia, are employed in traditional medicine for itching, dermatitis and other skin diseases. However, scientific studies on these two genera are scarce. Aiming to reveal the scientific basis of the folk medicinal use of these plants, the cytotoxicity, anti-inflammatory and anti-allergic activities of Brachychiton rupestris and Brachychiton discolor leaves extracts and fractions were evaluated. Also, phytochemical investigation of B. rupestris was performed to identify the compounds exerting the biological effect.MethodsExtracts as well as fractions of Brachychiton rupestris and Brachychiton discolor were tested for their cytotoxicity versus hepatoma HepG2, lung A549, and breast MDA-MB-231 cancer cell lines. Assessment of the anti-allergic activity was done using degranulation assay in RBL-2H3 mast cells. Anti-inflammatory effect was tested by measuring the suppression of superoxide anion production as well as elastase release in fMLF/CB-induced human neutrophils. Phytochemical investigation of the n-hexane, dichloromethane and ethyl acetate fractions of B. rupestris was done using different chromatographic and spectroscopic techniques.ResultsThe tested samples showed no cytotoxicity towards the tested cell lines. The nonpolar fractions of both B. rupestris and B. discolor showed potent anti-allergic potency by inhibiting the release of β-hexosaminidase. The dichloromethane fraction of both species exhibited the highest anti-inflammatory activity by suppressing superoxide anion generation and elastase release with IC50 values of 2.99 and 1.98 μg/mL, respectively for B. rupestris, and 0.78 and 1.57 μg/mL, respectively for B. discolor. Phytochemical investigation of various fractions of B. rupestris resulted in the isolation of β-amyrin acetate (1), β-sitosterol (2) and stigmasterol (3) from the n-hexane fraction. Scopoletin (4) and β-sitosterol-3-O-β-D-glucoside (5) were obtained from the dichloromethane fraction. Dihydrodehydrodiconiferyl alcohol 4-O-β-D-glucoside (6) and dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucoside (7) were separated from the ethyl acetate fraction. Scopoletin (4) showed anti-allergic and anti-inflammatory activity.ConclusionsIt was concluded that the nonpolar fractions of both Brachychiton species exhibited anti-allergic and anti-inflammatory activities.Electronic supplementary materialThe online version of this article (10.1186/s12906-018-2359-6) contains supplementary material, which is available to authorized users.

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“… 26 – 28 Many natural neolignans have displayed significant potential as a novel anti-inflammatory compound. 29 XH-14, which is also known as Danshen can bind the A1 adenosine receptor with relatively high affinity and inhibit adipocyte differentiation and induction of the adipokines in adipocytes. 30 XH-14 also might be attributed to its inhibiting effect on PGE2 production through blocking COX-2 gene expression as well as the activity of COX-2.…”

Section: Methodsmentioning

confidence: 99%

“…It seems that it can inhibit the production of PGE2 and at the same time can decrease lipoxygenase activity. 29 …”

Section: Methodsmentioning

confidence: 99%

“…It seems that it can inhibit the production of PGE2 and at the same time can decrease lipoxygenase activity. 29 Another anti-inflammatory property of benzofuran is the ability to inhibit NO production as a free radical that is involved in various inflammatory responses. 25,34 Therefore, it has been proposed that NO scavenging by benzofuran plays an important role in the regulation of inflammatory pathways.…”

Section: Anti-inflammatory Properties Of Natural Benzofuransmentioning

confidence: 99%

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<p>Recent Updates on Anti-Inflammatory and Antimicrobial Effects of Furan Natural Derivatives</p>

Alizadeh¹,

Moludi²,

Khodaei³

et al. 2020

JIR

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The furan nucleus is found in a large number of biologically active materials. In recent years, many natural furan derivatives were isolated and their biological effects were investigated. In this review, we focused on the anti-inflammatory and antimicrobial effects of some natural furans and discussed their effects on the immune system. Our investigation revealed that furan natural derivatives have effective antioxidant activities and exert regulatory effects on various cellular activities by modifying some signaling pathways such as MAPK (mitogen-activated Protein Kinase) and PPAR-ɣ (peroxisome proliferator-activated receptor gamma). The antimicrobial activity of these natural compounds was performed through selective inhibition of microbial growth and modification of enzymes. Further studies are needed for isolation and detection of different furan derivatives from natural compounds and investigation of their precise mechanisms for revealing health beneficial effects of these compounds.

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Anti-inflammatory neolignans from the roots of Magnolia officinalis

Cited by 20 publications

References 33 publications

Evaluation of Tyrosinase Inhibitory, Antioxidant, Antimicrobial, and Antiaging Activities of Magnolia officinalis Extracts after Aspergillus niger Fermentation

Evaluation of Tyrosinase Inhibitory, Antioxidant, Antimicrobial, and Antiaging Activities of Magnolia officinalis Extracts after Aspergillus niger Fermentation

Study of the anti-allergic and anti-inflammatory activity of Brachychiton rupestris and Brachychiton discolor leaves (Malvaceae) using in vitro models

<p>Recent Updates on Anti-Inflammatory and Antimicrobial Effects of Furan Natural Derivatives</p>

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