The impact of donor characteristics on the immune cell composition of second allografts in Chinese people

Chen, L; Yj, Chang; Xu, Lei; Huang, Xiao‐Jun

doi:10.1111/vox.12394

Cited by 5 publications

(1 citation statement)

References 24 publications

(35 reference statements)

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“…In haplo‐HCT with the Beijing protocol, Wang et al found that haplo‐HCT from young donors (< 30 years old) was associated with reduced NRM and better OS . This advantage may be related to the different cell populations (higher dose of CD34 + cells and CD3 + CD4 − CD8 − T cells in grafts from younger donors) . Moreover, in the TCD setting, donor age of less than 40 years was associated with faster immune reconstitution and decreased nonrelapse related mortality.…”

Section: Donor Agementioning

confidence: 99%

Donor selection for haploidentical hematopoietic cell transplantation‐ practice guidance

2018

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Haploidentical hematopoietic cell transplantation (haplo‐HCT) using either T‐cell depletion or T‐cell repletion (Beijing protocol or post‐transplantation cyclophosphamide) has shown great advancements in recent years. Haplo‐HCT can achieve comparable outcomes for transplantation from matched sibling donors and unrelated donors and has been used increasingly worldwide. For almost every patient, multiple haploidentical donors are available. Therefore, it is necessary to choose the best donor. However, there is no universal consensus on donor selection. The aim of this review was to discuss the general principles of and controversial factors related to donor selection. Several principles have been widely accepted. For example, human leukocyte antigen disparity is no longer taken into account, donor‐specific antibodies should be avoided, and younger donors and ABO matches are preferred. However, factors such as donor gender, family relationship, cytomegalovirus serological status, and natural killer cell alloreactivity are still controversial. Moreover, the factors may depend on the transplantation regimen. Finally, we summarize practical points for donor selection according to different haplo‐HCT protocols.

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Section: Donor Agementioning

confidence: 99%