ACE gene in pregnancy complications: Insights into future vascular risk

Fatini, Cinzia; Romagnuolo, Ilaria; Sticchi, Elena; Rossi, Lorenza; Cellai, Anna Paola; Rogolino, Angela; Abbate, Rosanna

doi:10.3109/10641955.2015.1115059

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…In addition, the articles which studied other hypertensive disorders of pregnancy and not PE, studies on offspring and those which were not original research were also excluded in the full-text screening stage. After further refinement, eight articles were removed for the following reasons: (i) two studies for using different cohorts for CVD and PE ( 20 , 37 ); (ii) one article for investigating different women with CVD and a history of PE, although from the same cohort ( 38 ); (iii) two for making conclusions on the shared risk of PE and CVD using genes predisposed to CVD from another study ( 39 , 40 ) and (iv) for not testing for CVD risk ( 39 , 40 ); (v) two for studying CVD risk in women with PE during delivery, but not conducting any follow-up research on CVD risk ( 41 , 42 ); and (vi) one study for not mentioning the number of women with PE ( 19 ). The included studies consisted of two studies on CVD endpoints following PE ( 35 , 36 ) and four on CVD risk factors following PE ( 37 – 40 ) (see Supplementary Tables S6 – S11 ).…”

Section: Resultsmentioning

confidence: 99%

Genomic variation associated with cardiovascular disease progression following preeclampsia: a systematic review

Krishnamurthy,

Nguyen,

Tran

et al. 2023

Front. Epidemiol.

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BackgroundWomen with a history of preeclampsia (PE) have been shown to have up to five times the risk of developing later-life cardiovascular disease (CVD). While PE and CVD are known to share clinical and molecular characteristics, there are limited studies investigating their shared genomics (genetics, epigenetics or transcriptomics) variation over time. Therefore, we sought to systematically review the literature to identify longitudinal studies focused on the genomic progression to CVD following PE.MethodsA literature search of primary sources through PubMed, Scopus, Web of Science and Embase via OVID was performed. Studies published from January 1, 1980, to July 28, 2023, that investigated genomics in PE and CVD were eligible for inclusion. Included studies were screened based on Cochrane systematic review guidelines in conjunction with the PRISMA 2020 checklist. Eligible articles were further assessed for quality using the Newcastle-Ottawa scale.ResultsA total of 9,231 articles were screened, with 14 studies subjected to quality assessment. Following further evaluation, six studies were included for the final review. All six of these studies were heterogeneous in regard to CVD/risk factor as outcome, gene mapping approach, and in different targeted genes. The associated genes were RGS2, LPA, and AQP3, alongside microRNAs miR-122-5p, miR-126-3p, miR-146a-5p, and miR-206. Additionally, 12 differentially methylated regions potentially linked to later-life CVD following PE were identified. The only common variable across all six studies was the use of a case-control study design.ConclusionsOur results provide critical insight into the heterogeneous nature of genomic studies investigating CVD following PE and highlight the urgent need for longitudinal studies to further investigate the genetic variation underlying the progression to CVD following PE.

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Section: Resultsmentioning

confidence: 99%

Genomic variation associated with cardiovascular disease progression following preeclampsia: a systematic review

Krishnamurthy,

Nguyen,

Tran

et al. 2023

Front. Epidemiol.

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“…In our previous clinical study, lower maternal and fetal Ang-(1-7) levels in plasma were at high risk for preterm birth [20]. Compared with healthy pregnant women, ACE D allele in pregnant women had an increased risk for giving SGA babies [47]. In a study from Brazil, The Ang II and ACE levels in plasma of boys who were born as SGA were higher (20% of increased levels) than those in boys at term birth [48].…”

Section: Discussionmentioning

confidence: 99%

Fetal But Not Maternal Angiotensin Converting Enzyme (ACE)-2 Gene Rs2074192 Polymorphism is Associated with Increased Risk of Being a Small For Gestational Age (SGA) Newborn

et al. 2018

Kidney Blood Press Res

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Background/Aims: The maternal and fetal Renin-Angiotensin-System is involved in the control of pregnancy outcomes such as blood pressure control and gestational age. However, very little is known about the impact of the angiotensin converting enzyme 2 (ACE2) on pregnancy outcome. We thus performed a prospective clinical observational study analyzing the association of maternal and fetal ACE2 gene rs2074192 polymorphism with fetal growth during pregnancy. Methods: 898 singleton pregnant women were prospectively recruited. 739 pregnant women finally participated in the study and were genotyped. 474 women also donated umbilical cord blood for gene analysis of their offspring. All data such as basic demographic information, data from birth records, biochemical and immunological parameters, as well as Doppler ultrasonographic findings during pregnancy were collected. Fetal and maternal ACE2 gene rs2074192 polymorphism was genotyped by DNA sequencing. Results: Our analysis showed that the maternal ACE2 gene rs2074192 polymorphism was not associated with gestational hypertension, gestational diabetes mellitus, anemia, postpartum hemorrhage and fetal growth. However, neonates having rs2074192 T allele were more likely to be born as small for gestational age (SGA) babies. After multivariable logistic regression considering known confounding, we could demonstrate that the neonatal rs2074192 T allele was an independent risk factor for SGA (OR: 22.93, 95%CI: 1.26∼418.77, P< 0.05). Conclusion: This is the first study showing that the babies but not their mothers with ACE2 gene rs2074192 T allele had a high risk for SGA, which contributes to metabolic syndrome and cardiovascular diseases in later life.

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“…In addition, the articles which studied other hypertensive disorders of pregnancy and not PE, studies on offspring and those which were not original research were also excluded in the full-text screening stage. After further refinement, eight articles were removed for the following reasons: (i) two studies for using different cohorts for CVD and PE (19,29) ; (ii) one article for investigating different women with CVD and a history of PE, although from the same cohort (30) ; (iii) two for making conclusions on the shared risk of PE and CVD using genes predisposed to CVD from another study (31,32) and (iv) for not testing for CVD risk (31,32) ; (v) two for studying CVD risk in women with PE during delivery, but not conducting any follow-up research on CVD risk (33,34) ; and (vi) one study for not mentioning the number of women with PE (18) (see Supplementary Tables S1-S6 for details). The included studies consisted of two studies on CVD endpoints following PE (35,36) and four on CVD risk factors following PE (37)(38)(39)(40) (see Supplementary Tables S1-S6).…”

Section: Study Selectionmentioning

confidence: 99%

“…The quality scores of six included studies (35)(36)(37)(38)(39)(40) and the excluded eight studies (18,19,29,(30)(31)(32)(33)41) that reached the final screening stage are shown in Supplementary Tables S1-S3. The six studies that passed the final screening were all case-control design.…”

Section: Quality Assessmentmentioning

confidence: 99%

Genomic variation associated with cardiovascular disease progression following preeclampsia: A systematic review

Krishnamurthy

Nguyen

Tram

et al. 2023

Preprint

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Background: Women with a history of preeclampsia (PE) have been shown to have up to five times the risk of developing later-life cardiovascular disease (CVD). While PE and CVD are known to share clinical and molecular characteristics, there are limited studies investigating their shared genomics (genetics, epigenetics or transcriptomics) variation over time. Therefore, we sought to systematically review the literature to identify longitudinal studies focused on the genomic progression to CVD following PE. Methods: A literature search of primary sources through PubMed, Scopus, Web of Science and Embase via OVID was performed. Studies published from January 1st, 1980, to February 02nd, 2023, that investigated genomics in PE and CVD were eligible for inclusion. Studies that did not include CVD or related risk factors as an outcome, were in non-human species or focused on pregnancy complications other than PE were excluded. Included studies were screened based on Cochrane systematic review guidelines in conjunction with the PRISMA 2020 checklist. Eligible articles were further assessed for quality using the Newcastle-Ottawa scale. Results: A total of 8929 articles were screened with 14 studies subjected to quality assessment. Following further evaluation, six studies were included for final review. All six of these studies were heterogeneous in regard to CVD/risk factors as an outcome, gene mapping approach, and in different targeted genes. The only common variable across all six studies was use of a case-control study design. Conclusions: Our results provide critical insight into the heterogeneous nature of genomic studies investigating CVD following PE and highlight the urgent need for longitudinal studies to further investigate the genetic variation underlying the progression to CVD following PE.

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ACE gene in pregnancy complications: Insights into future vascular risk

Cited by 6 publications

References 30 publications

Genomic variation associated with cardiovascular disease progression following preeclampsia: a systematic review

Genomic variation associated with cardiovascular disease progression following preeclampsia: a systematic review

Fetal But Not Maternal Angiotensin Converting Enzyme (ACE)-2 Gene Rs2074192 Polymorphism is Associated with Increased Risk of Being a Small For Gestational Age (SGA) Newborn

Genomic variation associated with cardiovascular disease progression following preeclampsia: A systematic review

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