Ultrasonic vocalization in murine experimental stroke: A mechanistic model of aphasia

Palmateer, Julie; Pan, Jie; Pandya, Arushi; Martin, Lianna; Kumar, Sungita; Ofomata, Adaora; Jones, Theresa A.; Gore, Andrea C.; Hurn, Patricia D.

doi:10.3233/rnn-150583

Cited by 4 publications

(2 citation statements)

References 32 publications

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“…Because of their social and affective significance and our growing mechanistic understanding, mouse USVs are increasingly being used as a behavioral measure in neurodevelopmental and neurolinguistic translational research ( de Chaumont et al, 2021 ; von Merten et al, 2014 ; Fröhlich et al, 2017 ; Yang et al, 2021 ; Binder et al, 2021 ; Hepbasli et al, 2021 ; Agarwalla et al, 2020 ; Tsai et al, 2012 ; Hodges et al, 2017 ). Their manipulation and precise measurement not only provide the basis for tackling many fundamental questions but also pave the way, via advanced animal models, for the discovery of essential, novel drug targets for many debilitating conditions such as autism-spectrum disorder ( Tsai et al, 2012 ; Silverman et al, 2010 ), Parkinson’s disease ( Ciucci et al, 2009 ), stroke-induced aphasia ( Palmateer et al, 2016 ), epilepsy aphasia syndromes ( Erata et al, 2021 ), progressive language disorders ( Menuet et al, 2011 ), chronic pain ( Palazzo et al, 2008 ), and depression/anxiety disorders ( Moskal and Burgdorf, 2018 ), where ultrasonic vocalizations serve as a biomarker for animal well-being and normal development. Consequently, we expect the scientific importance of mouse USVs to continue to increase in the coming years, highlighting the necessity to advance the methods required for their study.…”

Section: Introductionmentioning

confidence: 99%

Rodent ultrasonic vocal interaction resolved with millimeter precision using hybrid beamforming

Sterling

Teunisse

Englitz

2023

eLife

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Ultrasonic vocalizations (USVs) fulfill an important role in communication and navigation in many species. Because of their social and affective significance, rodent USVs are increasingly used as a behavioral measure in neurodevelopmental and neurolinguistic research. Reliably attributing USVs to their emitter during close interactions has emerged as a difficult, key challenge. If addressed, all subsequent analyses gain substantial confidence. We present a hybrid ultrasonic tracking system, HyVL, that synergistically integrates a high-resolution acoustic camera with high-quality ultrasonic microphones. HyVL is the first to achieve millimeter precision (~3.4-4.8mm, 91% assigned) in localizing USVs, ~3x better than other systems, approaching the physical limits (mouse snout ~ 10mm). We analyze mouse courtship interactions and demonstrate that males and females vocalize in starkly different relative spatial positions, and that the fraction of female vocalizations has likely been overestimated previously due to imprecise localization. Further, we find that when two male mice interact with one female, one of the males takes a dominant role in the interaction both in terms of the vocalization rate and the location relative to the female. HyVL substantially improves the precision with which social communication between rodents can be studied. It is also affordable, open-source, easy to set up, can be integrated with existing setups, and reduces the required number of experiments and animals.

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Section: Introductionmentioning

confidence: 99%

Rodent ultrasonic vocal interaction resolved with millimeter precision using hybrid beamforming

Sterling

Teunisse

Englitz

2023

eLife

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“…20,25,[46][47][48][49][50][51][52][53] Because of their social and affective significance and our growing mechanistic understanding, mouse USVs are increasingly being used as a behavioral measure in neurodevelopmental and neurolinguistic translational research. 26,32,49,[54][55][56][57][58][59] Their manipulation and precise measurement not only provide the basis for tackling many fundamental questions but also pave the way, via advanced animal models, for the discovery of essential, novel drug targets for many debilitating conditions such as autism-spectrum disorder 58,60 , Parkinson's disease 61 , strokeinduced aphasia 62 , epilepsy aphasia syndromes 63 , progressive language disorders 64 , chronic pain 65 , and depression/anxiety disorders 66 , where ultrasonic vocalizations serve as a biomarker for animal well-being and normal development. Consequently, we expect the scientific importance of mouse USVs to continue to increase in the coming years, highlighting the necessity to advance the methods required for their study.…”

Section: Introductionmentioning

confidence: 99%

Rodent ultrasonic vocal interaction resolved with millimeter precision using hybrid beamforming

Sterling

Englitz

2023

Preprint

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Ultrasonic vocalizations (USVs) fulfill an important role in communication and navigation in many species. Because of their social and affective significance, rodent USVs are increasingly used as a behavioral measure in neurodevelopmental and neurolinguistic research. Reliably attributing USVs to their emitter during close interactions has emerged as a difficult, key challenge. If addressed, all subsequent analyses gain substantial confidence. We present a hybrid ultrasonic tracking system, HyVL, that synergistically integrates a high-resolution acoustic camera with high-quality ultrasonic microphones. HyVL is the first to achieve millimeter precision (~3.4-4.8mm, 91% assigned) in localizing USVs, ~3x better than other systems, approaching the physical limits (mouse snout ~ 10mm). We analyze mouse courtship interactions and demonstrate that males and females vocalize in starkly different relative spatial positions, and that the fraction of female vocalizations has likely been overestimated previously due to imprecise localization. Further, we find that male mice vocalize more intensely when interacting with two mice, an effect mostly driven by the dominant male. HyVL substantially improves the precision with which social communication between rodents can be studied. It is also affordable, open-source, easy to set up, can be integrated with existing setups, and reduces the required number of experiments and animals.

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Rodent Vocalization Studies in Animal Models of the Autism Spectrum Disorder

Scattoni

Michetti

Ricceri

2018

Handbook of Ultrasonic Vocalization - A Window Into the Emotional Brain

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Ultrasonic vocalization in murine experimental stroke: A mechanistic model of aphasia

Abstract: These findings set a foundation for further studies of mechanisms and novel treatment strategies for post-stroke vocalization impairments.

Cited by 4 publications

References 32 publications

Rodent ultrasonic vocal interaction resolved with millimeter precision using hybrid beamforming

Rodent ultrasonic vocal interaction resolved with millimeter precision using hybrid beamforming

Rodent ultrasonic vocal interaction resolved with millimeter precision using hybrid beamforming

Rodent Vocalization Studies in Animal Models of the Autism Spectrum Disorder

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