Rodent Vocalization Studies in Animal Models of the Autism Spectrum Disorder

Scattoni, María Luisa; Michetti, Caterina; Ricceri, Laura

doi:10.1016/b978-0-12-809600-0.00042-1

Cited by 12 publications

(7 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ultrasonic vocalizations (USV) of laboratory rodents represent age-dependent indicators of animal emotional arousal [1][2][3][4][5][6] and may serve for modeling human diseases and the evaluation of drugs and medicaments effects [7][8][9][10][11][12][13][14][15][16][17][18][19][20]. The overwhelmingly preferred mice USV model [1,8,10,[21][22][23][24] is applicable for USV ontogeny [7,16,19,20,[25][26][27][28][29][30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Rapid development of mature vocal patterns of ultrasonic calls in a fast-growing rodent, the yellow steppe lemming (Eolagurus luteus)

Yurlova

Volodin

Ilchenko³

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

Ultrasonic vocalizations (USV) of laboratory rodents may serve as age-dependent indicators of emotional arousal and anxiety. Fast-growing Arvicolinae rodent species might be advantageous wild-type animal models for behavioural and medical research related to USV ontogeny. For the yellow steppe lemming Eolagurus luteus, only audible calls of adults were previously described. This study provides categorization and spectrographic analyses of 1176 USV calls emitted by 120 individual yellow steppe lemmings at 12 age classes, from birth to breeding adults over 90 days (d) of age, 10 individuals per age class, up to 10 USV calls per individual. The USV calls emerged since 1 st day of pup life and occurred at all 12 age classes and in both sexes. The unified 2-min isolation procedure on an unfamiliar territory was equally applicable for inducing USV calls at all age classes. Rapid physical growth (1 g body weight gain per day from birth to 40 d of age) and the early (9-12 d) eyes opening correlated with the early (9-12 d) emergence of mature vocal patterns of USV calls. The mature vocal patterns included a prominent shift in percentages of chevron and upward contours of fundamental frequency (f0) and the changes in the acoustic variables of USV calls. Call duration was the longest at 1-4 d, significantly shorter at 9-12 d and did not between 9-12-d and older age classes. The maximum fundamental frequency (f0max) decreased with increase of age class, from about 50 kHz in neonates to about 40 kHz in adults. These ontogenetic pathways of USV duration and f0max (towards shorter and lower-frequency USV calls) were reminiscent of those in laboratory mice Mus musculus.

show abstract

Section: Introductionmentioning

confidence: 99%

Rapid development of mature vocal patterns of ultrasonic calls in a fast-growing rodent, the yellow steppe lemming (Eolagurus luteus)

Yurlova

Volodin

Ilchenko³

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Following pivotal works, USV categorization has been used as a biomarker to identify qualitative alterations of the vocal repertoire in different mouse models of neurodevelopmental disorders. USV categorizations have been explored in both neonates and adult subjects modeling socio‐communicative deficits, including autism spectrum disorders 1,34 . Recent USV data from different mouse strains are also available, so far limited to early phases of postnatal development (first 2–3 weeks of postnatal life) 11,35,36 .…”

Section: Introductionmentioning

confidence: 99%

“…USV categorizations have been explored in both neonates and adult subjects modeling socio‐communicative deficits, including autism spectrum disorders. 1 , 34 Recent USV data from different mouse strains are also available, so far limited to early phases of postnatal development (first 2–3 weeks of postnatal life). 11 , 35 , 36 Together with previous data on cross fostering at birth 37 or embryo transfer procedure, 38 these data indicate that USV production and their acoustic variations are subjected to genetic and background control.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic vocalizations in laboratory mice: strain, age, and sex differences

Caruso

Marconi

Scattoni

et al. 2022

Genes Brain and Behavior

View full text Add to dashboard Cite

Mice produce ultrasonic vocalizations (USVs) in different social contexts across lifespan. There is ethological evidence that pup USVs elicit maternal retrieval and adult USVs facilitate social interaction with a conspecific. Analysis of mouse vocal and social repertoire across strains, sex and contexts remains not well explored. To address these issues, in inbred (C57BL/6, FVB) and outbred (CD‐1) mouse strains, we recorded and evaluated USVs as neonates and during adult social encounters (male–female and female–female social interaction). We showed significant strain differences in the quantitative (call rate and duration of USVs) and qualitative vocal analysis (spectrographic characterization) from early stage to adulthood, in line with specific patterns of social behaviors. Inbred C57BL/6 mice produced a lower number of calls with less internal changes and shorter duration; inbred FVB mice displayed more social behaviors and produced more syllables with repeated internal changes; outbred CD‐1 mice had an intermediate profile. Our results suggest specific vocal signatures in each mouse strain, thus helping to better define socio‐communicative profiles of mouse strains and to guide the choice of an appropriate strain according to the experimental settings.

show abstract

“…Classifying discomfort-related ultrasonic calls is an important prerequisite for their applicability as indicators of emotional arousal and welfare [2,6–13]. In addition, rodent USV are widely used in biomedical experiments modeling human affective and communicative disorders [11,14–18].…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic vocalization of pup and adult fat-tailed gerbils (Pachyuromys duprasi)

Zaytseva

Volodin

Ilchenko³

et al. 2019

PLoS ONE

View full text Add to dashboard Cite

Ultrasonic vocalizations (USVs) of laboratory rodents indicate animal emotional arousal and may serve as models of human disorders. We analysed spectrographically USV calls of pup and adult fat-tailed gerbils Pachyuromys duprasi during 420-s tests, including isolation, touch and handling. Based on combination of six different USV syllable contour shapes and six different note compositions, we classified 782 USV syllables of 24 pups aged 5–10 days to 18 types and 232 syllables of 7 adults to 24 types. Pups and adults shared 16 of these 26 USV types. Percentages of USV syllables with certain contour shapes differed between pups and adults. The contour shape and note composition significantly affected most acoustic variables of USV syllables in either pups or adults. The 1-note USV syllables were most common in either pups or adults. Pup USV syllables were overall longer and higher-frequency than adult ones, reminiscent of the USV ontogenetic pathway of bats and distinctive to rats and mice. We discuss that the USV syllable types of fat-tailed gerbils were generally similar in contour shapes and note compositions with USV syllable types of mice and rats, what means that software developed for automated classifying of mice ultrasound might be easily adapted or re-tuned to gerbil USV calls. However, using fat-tailed gerbils as model for biomedical research including control of USV vocalization is only possible since 6 th day of pup life, because of the delayed emergence of USV calls in ontogeny of this species.

show abstract

Rodent Vocalization Studies in Animal Models of the Autism Spectrum Disorder

Cited by 12 publications

References 109 publications

Rapid development of mature vocal patterns of ultrasonic calls in a fast-growing rodent, the yellow steppe lemming (Eolagurus luteus)

Rapid development of mature vocal patterns of ultrasonic calls in a fast-growing rodent, the yellow steppe lemming (Eolagurus luteus)

Ultrasonic vocalizations in laboratory mice: strain, age, and sex differences

Ultrasonic vocalization of pup and adult fat-tailed gerbils (Pachyuromys duprasi)

Contact Info

Product

Resources

About