Tagetes lucida Cav.: Ethnobotany, phytochemistry and pharmacology of its tranquilizing properties

Pérez-Ortega, Gimena; González-Trujano, Ma. Eva; Ángeles-López, Guadalupe Esther; Brindis, Fernando; Vibrans, Heike; Reyes‐Chilpa, Ricardo

doi:10.1016/j.jep.2016.01.040

Cited by 43 publications

(51 citation statements)

References 35 publications

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“…lucida belongs to the Asteraceae family. It is an ancient medicinal species that, according to the literature and recent verbal reports of merchants and healers of Mexican regions, is used to treat several gastrointestinal affections involving colic and ulcer, as well as to alleviate musculoskeletal pain [6]. Because of the ethnobotanical reports for T. lucida, in this study, we explored the analgesic-like response using the formalin test in rats, a nociceptive pain model that allowed exploring central (neurogenic) and peripheral (inflammatory) nociception, as well as the writhing test in mice, which mimics abdominal pain.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, metabolites of estragole are considered stronger hepatocarcinogens due to the formation of hepatic DNA adducts in vivo and in vitro [23]. An absence of this toxic constituent in Mexican species is important to mention because of the frequent medicinal use of the plant for several ailments [6].…”

Section: Discussionmentioning

confidence: 99%

“…The composition of the plant oils can vary based on the genetic constitution of the species and the agronomic conditions in which the plants grow [24,25], as well as the studied part of the plant. As an example, T. erecta is another Tagetes species commonly used in Mexican traditional medicine, in addition to T. lucida [6,26]. Its major constituents reported in the leaf oil were piperitone (52.4%), terpinolene (11.2%), limonene (7.6%), (Z)-myroxide (4.2%), and piperitenone (5.0%), in comparison to the flower oil that contained piperitone (28.5%), piperitenone (10.9%), (Z)-myroxide (7.9%), piperitenone oxide (7.2%), β-caryophyllene (7.0%), limonene (6.9%), and terpinolene (4.7%) as the major constituents [24].…”

Section: Discussionmentioning

confidence: 99%

“…However, other properties were reported, such as its antibacterial, insecticidal [10,11], cytotoxic [12,13], and antioxidant activities [10]. Regarding the central nervous system (CNS), pharmacological studies reported antidepressant [14] and anxiolytic/sedative properties for this species [6]. In this study, the acute toxicity and potential analgesic-like effects of the Tagetes lucida essential oil and the bioactive compound β-caryophyllene were explored in two animal models of pain.…”

Section: Introductionmentioning

confidence: 99%

“…They show up after the rainy season, and they are, in fact, a symbol of the culmination of the agricultural cycle even today in many parts of Mexico. The day "Fiesta del Pericón" is celebrated in various parts of Mexico from 28-29 September in honor of San Miguel [6].…”

Section: Introductionmentioning

confidence: 99%

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Role of β-Caryophyllene in the Antinociceptive and Anti-Inflammatory Effects of Tagetes lucida Cav. Essential Oil

et al. 2020

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Tagetes lucida Cav. (Asteraceae) is an ancient medicinal plant commonly used to alleviate pain. Nevertheless, scientific studies validating this property are lacking in the literature. Animal models of pain were used to evaluate the antinociceptive and anti-inflammatory activities of T. lucida essential oil (TLEO) and a bioactive metabolite. The chemical constitution and possible toxicity of the extract and the mechanism of action of β-caryophyllene were also explored. Temporal course curves and dose–response graphics were generated using TLEO (0.1–10 mg/kg or 3.16–31.62 mg/kg) and β-caryophyllene (3.16–10 mg/kg). Metamizole (80 mg/kg) and indomethacin (20 mg/kg) were used as reference drugs in the formalin assay and writhing test in rats and mice, respectively. The β-caryophyllene mechanism of action was explored in the presence of naloxone (1 mg/kg), flumazenil (10 mg/kg), WAY100635 (0.16 mg/kg), or nitro-l-arginine methyl ester (L-NAME) (20 mg/kg) in the formalin test in rats. GC/MS analysis demonstrated the presence of geranyl acetate (49.89%), geraniol (7.92%), and β-caryophyllene (6.27%). Significant and dose-dependent antinociceptive response was produced by TLEO and β-caryophyllene without the presence of gastric damage. In conclusion, β-caryophyllene was confirmed as a bioactive compound in the T. lucida analgesic properties by involving the participation of receptors like opioids, benzodiazepines, and Serotonin 1A receptor (5-HT1A), as well as nitric oxide.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of β-Caryophyllene in the Antinociceptive and Anti-Inflammatory Effects of Tagetes lucida Cav. Essential Oil

et al. 2020

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A Review of the Chemistry and Biological Activities of Natural Colorants, Dyes, and Pigments: Challenges, and Opportunities for Food, Cosmetics, and Pharmaceutical Application

Pasdaran

Zare

Hamedi

et al. 2023

Chemistry & Biodiversity

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Natural pigments are important sources for the screening of bioactive lead compounds. This article reviewed the chemistry and therapeutic potentials of over 570 colored molecules from plants, fungi, bacteria, insects, algae, and marine sources. Moreover, related biological activities, advanced extraction, and identification approaches were reviewed. A variety of biological activities, including cytotoxicity against cancer cells, antioxidant, anti‐inflammatory, wound healing, anti‐microbial, antiviral, and anti‐protozoal activities, have been reported for different pigments. Considering their structural backbone, they were classified as naphthoquinones, carotenoids, flavonoids, xanthones, anthocyanins, benzotropolones, alkaloids, terpenoids, isoprenoids, and non‐isoprenoids. Alkaloid pigments were mostly isolated from bacteria and marine sources, while flavonoids were mostly found in plants and mushrooms. Colored quinones and xanthones were mostly extracted from plants and fungi, while colored polyketides and terpenoids are often found in marine sources and fungi. Carotenoids are mostly distributed among bacteria, followed by fungi and plants. The pigments isolated from insects have different structures, but among them, carotenoids and quinone/xanthone are the most important. Considering good manufacturing practices, the current permitted natural colorants are: Carotenoids (canthaxanthin, β‐carotene, β‐apo‐8′‐carotenal, annatto, astaxanthin) and their sources, lycopene, anthocyanins, betanin, chlorophyllins, spirulina extract, carmine and cochineal extract, henna, riboflavin, pyrogallol, logwood extract, guaiazulene, turmeric, and soy leghemoglobin.

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Ethnobotanical Science in the Clouds: Useful Plants of Northeastern Oaxaca, Mexico

Rendón-Aguilar

Bravo-Avilez

Bernal-Ramírez

et al. 2023

Ethnobotany of the Mountain Regions of Mexico

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Tagetes lucida Cav.: Ethnobotany, phytochemistry and pharmacology of its tranquilizing properties

Cited by 43 publications

References 35 publications

Role of β-Caryophyllene in the Antinociceptive and Anti-Inflammatory Effects of Tagetes lucida Cav. Essential Oil

Role of β-Caryophyllene in the Antinociceptive and Anti-Inflammatory Effects of Tagetes lucida Cav. Essential Oil

A Review of the Chemistry and Biological Activities of Natural Colorants, Dyes, and Pigments: Challenges, and Opportunities for Food, Cosmetics, and Pharmaceutical Application

Ethnobotanical Science in the Clouds: Useful Plants of Northeastern Oaxaca, Mexico

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