IgE and Fcε
            <scp>RI</scp>
            are highly expressed on innate cells in psoriasis

Kx, Yan; Huang, Qiong; Fang, Xu; Zhang, Zh.; Han, Ling; Gadaldi, Karolina; Kang, Kyung‐Sun; Zhang, Zheng; Xu, J H; Yawalkar, Nikhil

doi:10.1111/bjd.14459

Cited by 19 publications

(25 citation statements)

References 36 publications

(49 reference statements)

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“…The result is consistent with some studies [7][8][9][10][11]. Yan et al demonstrated that 39% of patients with psoriasis had elevated serum IgE concentrations and they observed that lesional skin of patients with psoriasis contains more IgE+ and FceRI+ cells [20]. Chen et al reported that the serum IgE level was elevated in 46% psoriatic patients [11].…”

Section: Discussionsupporting

confidence: 90%

High Serum IgE Concentration in Patients with Psoriasis

Zheng¹

2017

CRDOA

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Section: Discussionsupporting

confidence: 90%

High Serum IgE Concentration in Patients with Psoriasis

Zheng¹

2017

CRDOA

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“…Its efficacy has been shown even for psoriatic patients with high total serum IgE levels and, indeed, UST lowered the number of IgE-and FceRI-bearing cells in the lesional skin. 5 However, previous case reports have also documented that UST provoked or exacerbated AD-like symptoms paradoxically while improving psoriatic symptoms. 6,7 We also experienced a similar reciprocal phenomenon following UST administration in a couple of psoriatic patients.…”

Section: Discussionmentioning

confidence: 97%

“…Ustekinumab is one of the most commonly used biologics in psoriatic patients. Its efficacy has been shown even for psoriatic patients with high total serum IgE levels and, indeed, UST lowered the number of IgE‐ and FcεRI‐bearing cells in the lesional skin . However, previous case reports have also documented that UST provoked or exacerbated AD‐like symptoms paradoxically while improving psoriatic symptoms .…”

Section: Discussionmentioning

confidence: 99%

Exacerbation of atopic dermatitis symptoms by ustekinumab in psoriatic patients with elevated serum immunoglobulin E levels: Report of two cases

Ishiuji

Umezawa

Asahina

et al. 2018

The Journal of Dermatology

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Psoriasis is a chronic inflammatory skin disease mainly mediated by a T-helper cell subset, Th17 cells. Recently, increased levels of total serum immunoglobulin (Ig)E have been reported in a subset of psoriatic patients. Ustekinumab (UST) is one of the most commonly used biologic agents for the treatment of moderate to severe plaque psoriasis, and a previous report also documented effectiveness of UST for psoriatic patients with high serum IgE levels. We experienced two psoriatic patients with high serum IgE levels, in whom UST completely improved psoriasis but paradoxically provoked or exacerbated atopic dermatitis (AD)-like symptoms. This reciprocal phenomenon suggests the shift of Th balance toward Th2, along with altered profiles of inflammatory cytokines. It appears prudent to consider the possibility of such adverse effects when treating psoriatic patients with UST with concomitant AD symptoms, a history of AD or high serum IgE levels.

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“…Interestingly, MC and its mediators are increased in psoriatic lesional skin . Moreover, increased levels of FcεRI receptor, the high‐affinity surface receptor for IgE implicated in mediating MC allergic responses, have recently been reported in psoriasis. Mast cells are involved in allergy and inflammation and are numerous in the normal skin where they express considerable phenotypic variability, possibly in response to local and systemic neuroendocrine triggers …”

Section: Discussionmentioning

confidence: 99%

TNF stimulates IL‐6, CXCL8 and VEGF secretion from human keratinocytes via activation of mTOR, inhibited by tetramethoxyluteolin

Patel

Tsilioni

Weng

et al. 2018

Experimental Dermatology

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Psoriasis is an autoimmune skin disease characterized by keratinocyte hyperproliferation and chronic inflammation. The pathogenesis of psoriasis involves proinflammatory cytokines, such as tumor necrosis factor (TNF), but the mechanism of keratinocyte activation is not well understood. Here, we show that TNF (10 or 50 ng/mL) stimulates a significant (P < .0001) gene expression and secretion of proinflammatory IL-6, CXCL8 and VEGF from both cultured human HaCaT and normal epidermal human keratinocytes (NHEKs). This effect occurs via activation of the mammalian target of rapamycin (mTOR) signalling complex as shown by Western blot analysis and phospho-ELISAs. Pretreatment with the novel natural flavonoid tetramethoxyluteolin (10-100 μmol L ) significantly (P < .0001) inhibits gene expression and secretion (P < .0001) of all 3 mediators in a concentration-dependent manner. Moreover, tetramethoxyluteolin (50 μmol L ) appears to be a potent inhibitor of the phosphorylated mTOR substrates (pmTOR , pp70S6K and p4EBP1 ) as compared to known mTOR inhibitors in keratinocytes. The present findings indicate that TNF stimulates skin inflammation via mTOR signalling. Inhibition by tetramethoxyluteolin may be used in the treatment for psoriasis.

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IgE and Fcε RI are highly expressed on innate cells in psoriasis

Abstract: IgE might participate in the development of psoriasis by activating FcεRI-bearing cells.

Cited by 19 publications

References 36 publications

High Serum IgE Concentration in Patients with Psoriasis

High Serum IgE Concentration in Patients with Psoriasis

Exacerbation of atopic dermatitis symptoms by ustekinumab in psoriatic patients with elevated serum immunoglobulin E levels: Report of two cases

TNF stimulates IL‐6, CXCL8 and VEGF secretion from human keratinocytes via activation of mTOR, inhibited by tetramethoxyluteolin

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