Daidzein-loaded nanostructured lipid carriers-PLGA nanofibers for transdermal delivery

Song, Jia; Fan, Xiucong; Shen, Qi

doi:10.1016/j.ijpharm.2016.02.003

Cited by 42 publications

(12 citation statements)

References 32 publications

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“…In Vivo Safety Assay : In vivo safety evaluations of S‐PHB were implemented using the skin stimulation experiment . Initially, BALA/c mice were shaved of the back hair, disinfected and coated with S‐PHB with different concentrations from 6.25 to 100 mg mL −1 of MIC to evaluate skin irritation.…”

mentioning

confidence: 99%

A New Antimicrobial Agent: Poly (3‐hydroxybutyric acid) Oligomer

Zhang

et al. 2019

Macromolecular Bioscience

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In this work, it is first reported that the poly (3‐hydroxybutyric acid) (PHB) oligomer with a few degrees of polymerization possesses effective antibacterial and antifungal properties. Two preparation methods for the PHB oligomer are described, namely, one‐step ring‐opening polymerization of β‐butyrolactone and extraction from the fermented PHB polymer. An appropriate amount of the synthesized PHB oligomer shows no physiological toxicity to the skin and major organs of mice. Topological application of the synthesized PHB oligomer imparts antimicrobial ability to non‐antibacterial fabrics with washing resistance. The synthesized PHB oligomer offers effective sterilization and promotes wound healing in infected nude mice. Most importantly, the PHB oligomer is also reactive to drug‐resistant bacteria. These results suggest that the PHB oligomer is not only a great candidate for antimicrobial modification but also a promising one for biomedical applications. Finally, the antimicrobial mechanisms of the PHB oligomer are revealed, and these include disruption of biofilm and the bacterial wall/membrane, leakage of the intracellular content, inhibition of protein activity, and change in the transmembrane potential.

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confidence: 99%

A New Antimicrobial Agent: Poly (3‐hydroxybutyric acid) Oligomer

Zhang

et al. 2019

Macromolecular Bioscience

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“…DZ and prepared nanoparticles were placed into the donor compartments. Meanwhile, each receptor compartment was filled with phosphate‐buffered saline (PBS) (pH = 7.4) and maintained at 37±0.5°C with magnetic stirring at 300 rpm [15]. During the experiment, bubbles were avoided as much as possible in the receptor compartments [16].…”

Section: Methodsmentioning

confidence: 99%

Core–shell‐type polymer–lipid nanoparticles for the transdermal delivery of daidzein

Wusiman

Sun

Zuo

et al. 2018

Micro & Nano Letters

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Daidzein (DZ) is an ideal Chinese herb for treating cardiocerebrovascular disease. Despite its poor water solubility and limited application, DZ was successfully loaded, along with penetration enhancer azone, onto core-shell-type polymer-lipid nanoparticles through a two-step preparation method. The mean particle diameter, encapsulation efficiency, and drug-loading rate of DZ-polymer-azone-lipid nanoparticles (D-P-Azone-LNs) were 77.59 ± 2.26 nm, 79.91% ± 1.46%, and 1.50% ± 0.02%, respectively. In skin penetration experiment, the cumulative amount of DZ from D-P-Azone-LN reached 14.91 μg•cm −2 at 72 h. This amount was 1.44 and 6.01 times higher than those of DZ-polymer-lipid nanoparticles (D-P-LNs) and DZ solution, respectively. Confocal laser scanning microscopy was used to conduct a qualitative analysis. In vivo study, D-P-Azone-LN achieved better skin retention than those of D-P-LN and DZ. Furthermore, no significant irritation was observed in the skin irritation experiment. These results suggested that the core-shell polymer-lipid nanoparticles, which combined the properties of polymer and lipid nanoparticles, can offer a useful formulation for enhancing the skin permeation of drug for transdermal delivery.

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“…Last but not least, PLGA nanofibers were also explored for transdermal delivery of drugs with poor oral absorption and limited bioavailability, e.g., Daidzein, a promising candidate for treating cardiovascular and cerebrovascular diseases [97], or for local delivery of anticancer drugs (for a review, see [98]).…”

Section: Nanofibers From Synthetic Degradable Polymersmentioning

confidence: 99%

Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Synthetic Polymers

Bačáková¹,

Zikmundová²,

Pajorová³

et al. 2020

Applications of Nanobiotechnology

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Nanofibrous scaffolds are popular materials in all areas of tissue engineering, because they mimic the fibrous component of the natural extracellular matrix. In this chapter, we focused on the application of nanofibers in skin tissue engineering and wound healing, because the skin is an organ with several vitally important functions, particularly barrier, thermoregulatory, and sensory functions. Nanofibrous meshes not only serve as carriers for skin cells but also can prevent the penetration of microbes into wounds and can keep appropriate moisture in the damaged skin. The nanofibrous meshes have been prepared from a wide range of synthetic and nature-derived polymers. This review is concentrated on synthetic non-degradable and degradable polymers, which have been explored for skin tissue engineering and wound healing. These synthetic polymers were often combined with natural polymers of the protein or polysaccharide nature, which improved their attractiveness for cell colonization. The nanofibrous scaffolds can also be loaded with various bioactive molecules, such as growth factors, hormones, vitamins, antioxidants, antimicrobial, and antitumor agents. In advanced tissue engineering approaches, the cells on the nanofibrous scaffolds are cultured in dynamic bioreactors enabling appropriate mechanical stimulation of cells and at air-liquid interface. This chapter summarizes recent results achieved in the field of nanofiber-based skin tissue engineering, including results of our research group.

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Daidzein-loaded nanostructured lipid carriers-PLGA nanofibers for transdermal delivery

Cited by 42 publications

References 32 publications

A New Antimicrobial Agent: Poly (3‐hydroxybutyric acid) Oligomer

A New Antimicrobial Agent: Poly (3‐hydroxybutyric acid) Oligomer

Core–shell‐type polymer–lipid nanoparticles for the transdermal delivery of daidzein

Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Synthetic Polymers

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