Treatment and survival of patients with insular thyroid carcinoma: 508 cases from the National Cancer Data Base

Abstract

Treatment recommendations should incorporate the use of radioactive iodine after complete surgical resection and clearance of involved nodal basins. © 2016 Wiley Periodicals, Inc. Head Neck 38: 906-912, 2016.

Propensity score matching analysis of the prognosis for the rare insular subtype of thyroid cancer based on SEER database

“…Likewise, the all-cause mortality rate in patients with ITC was better than those in patients with CPTC and FTC. This result was unexpected and maybe have potential prognostic and therapeutic implications for patients with ITC , as it was inconsistent with previously published data [ 15 , 24 , 25 , 28 , 29 ] ,and it maybe more trustworthy because we performed PSM analyses to adjust for biases from different baseline characteristics of two histotype groups , Surgeons have not yet established the best treatment option for ITC, and our results may provide guidance for clinicians and may also influence the new American Thyroid Association guidelines.…”

“…ITC is considered morphologically and biologically intermediate compared to well-differentiated thyroid carcinomas (PTC and FTC) on one hand and anaplastic carcinoma of the thyroid on the other; it was incorporated into the World Health Organization classification of poorly differentiated thyroid carcinoma in 2004 [ 21 , 22 ]. According to the literature, disease-related mortality due to ITC is higher than that due to DTC [ 15 , 23 – 25 ], and its insular histotype is independently associated with patient survival [ 26 , 27 ]. Because of sample size limitations owing to the overall rarity of ITC, the paucity of available studies have precluded the accurate determination of this disease's prognosis.…”

“…Its morphological features lie between those of well-differentiated carcinoma (papillary or follicular) and undifferentiated or anaplastic carcinoma of the thyroid [ 12 , 13 ]. This type of thyroid carcinoma is considered an aggressive cancer with a high propensity for local recurrence and distant metastasis [ 14 , 15 ]; it reportedly has a worse prognosis than classic thyroid carcinomas [ 9 , 12 , 13 , 15 ]. However, some studies did not find a significant difference in prognosis between patients with ITC and those with differentiated thyroid cancer: papillary and/or follicular thyroid carcinomas (FTCs) [ 16 , 17 ].…”

Radiation therapy dose is associated with improved survival for unresected anaplastic thyroid carcinoma: Outcomes from the National Cancer Data Base

“…Although numerically rare, comprising from 1% to 2% of all thyroid cancers, it has a grim prognosis, because ATC accounts for approximately 40% of all thyroid cancer‐related deaths . Median survival ranges from 3 months to 10 months, with long‐term survival rates of <20%, because patients routinely present with advanced disease . Patients with ATC often present with rapidly growing and immediately threatening local tumor that is not amenable to meaningful resection.…”

“…[1][2][3] Median survival ranges from 3 months to 10 months, with long-term survival rates of <20%, because patients routinely present with advanced disease. 4,5 Patients with ATC often present with rapidly growing and immediately threatening local tumor that is not amenable to meaningful resection. To date, there still are no standard, highly effective treatment regimens for ATC, but treatment is generally multimodal.…”