The protective effect of blueberry anthocyanins against perfluorooctanoic acid-induced disturbance in planarian (Dugesia japonica)

Yuan, Zuoqing; Zhang, Jianyong; Tu, Changchao; Wang, Zhijing; Xin, Wenpeng

doi:10.1016/j.ecoenv.2016.01.019

Cited by 16 publications

(6 citation statements)

References 21 publications

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“…The mPTP activity mainly appeared as a property of mammalian and yeast mitochondria, where it was intensively investigated. However recently the mPTP was also reported in mussel [183], in sea urchin oocytes [184], in the nematode Caenorhabditis elegans [185], in plathelminths [186] and insects [187,188], while it is still controversial in crustaceans [189,190]. Indeed, it is not a "vertebrate invention" to rule cell fate, as initially thought [191].…”

Section: How the Atp Synthase/hydrolase Is Involved In The Mitochondrial Permeability Transition Porementioning

confidence: 99%

Molecular and Supramolecular Structure of the Mitochondrial Oxidative Phosphorylation System: Implications for Pathology

Nesci

Trombetti

Pagliarani

et al. 2021

Life

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Under aerobic conditions, mitochondrial oxidative phosphorylation (OXPHOS) converts the energy released by nutrient oxidation into ATP, the currency of living organisms. The whole biochemical machinery is hosted by the inner mitochondrial membrane (mtIM) where the protonmotive force built by respiratory complexes, dynamically assembled as super-complexes, allows the F1FO-ATP synthase to make ATP from ADP + Pi. Recently mitochondria emerged not only as cell powerhouses, but also as signaling hubs by way of reactive oxygen species (ROS) production. However, when ROS removal systems and/or OXPHOS constituents are defective, the physiological ROS generation can cause ROS imbalance and oxidative stress, which in turn damages cell components. Moreover, the morphology of mitochondria rules cell fate and the formation of the mitochondrial permeability transition pore in the mtIM, which, most likely with the F1FO-ATP synthase contribution, permeabilizes mitochondria and leads to cell death. As the multiple mitochondrial functions are mutually interconnected, changes in protein composition by mutations or in supercomplex assembly and/or in membrane structures often generate a dysfunctional cascade and lead to life-incompatible diseases or severe syndromes. The known structural/functional changes in mitochondrial proteins and structures, which impact mitochondrial bioenergetics because of an impaired or defective energy transduction system, here reviewed, constitute the main biochemical damage in a variety of genetic and age-related diseases.

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Section: How the Atp Synthase/hydrolase Is Involved In The Mitochondrial Permeability Transition Porementioning

confidence: 99%

Molecular and Supramolecular Structure of the Mitochondrial Oxidative Phosphorylation System: Implications for Pathology

Nesci

Trombetti

Pagliarani

et al. 2021

Life

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“…The D. japonica was collected as described previously (Yuan et al, 2016). PFOA was purchased from Sigma-Aldrich Chemical Co. (St. Louis, MO, USA) and dissolved in autoclaved distilled water containing 0.005% (v/v) dimethyl sulfoxide (DMSO) to the desired concentrations.…”

Section: Materials and Animal Handlingmentioning

confidence: 99%

“…Mitochondria of all treatment groups were isolated using a Mitochondria Isolation Kit (Beyotime, Shanghai, China). Activities of SDH, COX and MAO were determined using the method of Yuan et al (2016). Protein contents were determined using the Bradford method.…”

Section: Mitochondrial Enzyme Activitiesmentioning

confidence: 99%

“…Per uorooctanoic acid (PFOA) has been discovered in organisms and the environment, particularly as an environmental pollutant in aquatic environments (Lindstrom et al, 2011;Hu et al, 2016), resulting in a variety of toxicological effects (Li et al, 2017). PFOA causes acute toxic effects (Yuan et al, 2015), oxidative stress (Feng et al, 2017), cell apoptosis (Liu et al, 2007), mitochondrial dysfunction (Yuan et al, 2016) and decreased enzymatic activities (Yuan et al, 2014). Therefore, evaluation of the combined effects of WV and PFOA on aquatic organisms is important.…”

Section: Introductionmentioning

confidence: 99%

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The Combined Effects of Wood Vinegar and Perfluorooctanoic Acid on Enzymatic Activities, DNA Integrity and Gene Transcription in Dugesia Japonica

Zhang

Sun

et al. 2021

Preprint

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Perfluorooctanoic acid (PFOA) has been identified widely in aquatic environments, while there are few reports detailing the environmental risk of wood vinegar (WV) on freshwater ecosystems. We used freshwater planarians, Dugesia japonica, to evaluate the combined effects of PFOA and WV by examining the adverse influence of enzymatic activities, DNA damage and gene transcription on planarians. Compared with control and PFOA groups, the malonaldehyde content was lower in planarians treated with WV. In addition, WV enhanced the activities of antioxidant enzymes and mitochondrial enzymes, relieving the toxicity effects of PFOA. We also studied the genotoxicity of PFOA and WV on planarians using the comet assay. WV decreased the proportion of DNA in the tail and the olive tail moment. Furthermore, expression of gpx, gst and gr genes in planarians was significantly altered following exposure to both PFOA and WV, compared with individual exposure. Our results suggest that WV could alleviate the adverse effects of PFOA on the aquatic environment, but ecological risk assessments and toxicological safety evaluations of WV are necessary.

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“…Blueberries ( Vaccinium corymbosum L. ) are rich in antioxidant compounds such as proanthocyanidins, flavonols, anthocyanins and the phenolic acids ferulic, pcoumaric, chlorogenic and caffeic acids (Yuan et al, 2016). In particular, the health benefits of blueberry anthocyanins (BA) have been demonstrated, and have been shown to reduce the risk cardiovascular disorders, neurodegenerative diseases and some cancers.…”

Section: Introductionmentioning

confidence: 99%

Blueberry extract attenuates γ-radiation-induced hepatocyte damage by modulating oxidative stress and suppressing NF-κB in male rats

Alkhalf

Khalifa

2018

Saudi Journal of Biological Sciences

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Radiation exposure is known to produce many harmful effects in biological systems, and these effects are often mediated by oxygen free radicals. Because blueberries are rich in antioxidant compounds such as anthocyanins and phenolic acids, we divided forty adult rats into four treatment groups of 10 (G1–4) as follows: G1 rats were used as a control, G2 rats were irradiated with 8 Gy at 2 Gy/week at a dose rate of 0.5 Gy/min, G3 rats were administered blueberry extract (200 mg/kg) and G4 rats were administered blueberry extract during the same irradiation period. In subsequent determinations, γ-irradiated rats had increased levels of cholesterol, triglyceride, high density lipoprotein (HDL) and low density lipoprotein (LDL), and significantly elevated liver enzyme activities, including alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP), and total bilirubin. In contrast, significant reductions in albumin, total protein and globulin were observed, whereas gamma irradiation decreased activities of the antioxidant enzymes glutathione (GSH), catalase (CAT), xanthine dehydrogenase (XDH) and superoxide dismutase (SOD). We also observed incremental increases in DNA fragmentation percentages and histopathological changes in liver tissues. Serum pro-inflammatory cytokine levels (IL-6, IL-10 and TNF-α) were significantly elevated and hepatic NF-кB was upregulated. In G4 rats, treatments with blueberry extract restored liver pro-oxidant status, reduced cytokine levels, ameliorated histopathological parameters and reduced DNA damage. In conclusion, γ-radiation exerts toxic effects in the rat livers, and blueberry extract is protective against these.

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The protective effect of blueberry anthocyanins against perfluorooctanoic acid-induced disturbance in planarian (Dugesia japonica)

Cited by 16 publications

References 21 publications

Molecular and Supramolecular Structure of the Mitochondrial Oxidative Phosphorylation System: Implications for Pathology

Molecular and Supramolecular Structure of the Mitochondrial Oxidative Phosphorylation System: Implications for Pathology

The Combined Effects of Wood Vinegar and Perfluorooctanoic Acid on Enzymatic Activities, DNA Integrity and Gene Transcription in Dugesia Japonica

Blueberry extract attenuates γ-radiation-induced hepatocyte damage by modulating oxidative stress and suppressing NF-κB in male rats

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