A multi-functional nanoplatform for tumor synergistic phototherapy

Zhang, Huijuan; Jiao, Xiaojing; Chen, Qianqian; Ji, Yandan; Zhu, Xing; Zhang, Zhenzhong

doi:10.1088/0957-4484/27/8/085104

Cited by 16 publications

(10 citation statements)

References 44 publications

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“…100 The up-conversion method of transforming NIR light into photoactivated chemotherapy at the lesion site has attracted much attention. 101 Xu et al prepared UCNPs with reversible charge and shrinking size to better promote cell internalization. 102 The hydrolysis of PEG-PAH-DMMA layer emerged UCNs loaded Pt(IV) prodrug by charge reversed in TME.…”

Section: Msr-ddss For Tumor Theranosticsmentioning

confidence: 99%

Advances in Multiple Stimuli-Responsive Drug-Delivery Systems for Cancer Therapy

Jia¹,

Teng²,

Lingyu³

et al. 2021

IJN

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Nanomedicines afford unique advantages in therapeutic intervention against tumors. However, conventional nanomedicines have failed to achieve the desired effect against cancers because of the presence of complicated physiological fluids and the tumor microenvironment. Stimuli-responsive drug-delivery systems have emerged as potential tools for advanced treatment of cancers. Versatile nano-carriers co-triggered by multiple stimuli in different levels of organisms (eg, extracorporeal, tumor tissue, cell, subcellular organelles) have aroused widespread interest because they can overcome sequential physiological and pathological barriers to deliver diverse therapeutic “payloads” to the desired targets. Furthermore, multiple stimuli-responsive drug-delivery systems (MSR-DDSs) offer a good platform for co-delivery of agents and reversing multidrug resistance. This review affords a comprehensive overview on the “landscape” of MSR-DDSs against tumors, highlights the design strategies of MSR-DDSs in recent years, discusses the putative advantage of oncotherapy or the obstacles that so far have hindered the clinical translation of MSR-DDSs.

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Section: Msr-ddss For Tumor Theranosticsmentioning

confidence: 99%

Advances in Multiple Stimuli-Responsive Drug-Delivery Systems for Cancer Therapy

Jia¹,

Teng²,

Lingyu³

et al. 2021

IJN

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“…For instance, since they have thermal properties when exposed to infrared light, 43 their heating could be simultaneously used for diagnosis and disease treatments. Zhang et al 44 observed that CNT can be used as a photosensitive drug carrier both in vitro and in vivo to fight tumor cells by hyperthermia. Nanoparticles delivering hematoporphyrin monomethyl ether help to potentiate the antitumor effects of photodynamic therapy against breast cancer cells (MCF-7), increasing cancer cell death and exhibiting low toxicity in healthy tissues irradiated with laser light.…”

Section: ■ Applicability Of Cnts In Cancer Diagnosismentioning

confidence: 99%

Carbon Nanotube as a Tool for Fighting Cancer

2017

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In 2015, cancer was the cause of almost 22% of deaths worldwide. The high frequency of relapsing diseases and metastasis requires the development of new diagnostic and therapeutic approaches, and the use of nanomaterials is a promising tool for fighting cancer. Among the more extensively studied nanomaterials are carbon nanotubes (CNTs), synthesized as graphene sheets, whose spiral shape is varied in length and thickness. Their physicochemical features, such as the resistance to tension, and thermal and electrical conductivity, allow their application in several fields. In this review, we show evidence supporting the applicability of CNTs in biomedical practice as nanocarriers for drugs and immunomodulatory material, emphasizing their potential for use in cancer treatment.

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“…Phototherapy as a new powerful cancer treatment technology has aroused tremendous concern in the light of its high selectivity, minimal invasiveness, remarkable reduced damage to normal tissues, and rather effective therapeutic efficacy compared with traditional methods. − Phototherapy, generally including photothermal therapy (PTT) and photodynamic therapy (PDT), relies on light-harvesting material to generate adverse factor from laser energy to destroy cancer cells. PTT employs a photothermal agent to generate heat from near infrared (NIR) light energy, leading to thermal burn of cancer cells. − However, PDT utilizes specific wavelength light to activate photosensitizer and transfer energy to molecular O 2 to produce reactive oxygen species (ROS), leading to strong oxidization damage of cancer cells .…”

Section: Introductionmentioning

confidence: 99%

“…Titanium-based materials have triggered an explosion of research interests in many fields such as catalysis, environment, aerospace, cosmetics, energy, and biomedicine. , In recent years, as the finest biocompatible metallic element in nature, titanium-based materials with high stability, nontoxicity, abundant storage, and unique photocatalytic activity have been successfully applied in cancer treatment, such as PDT, ,− PTT, sonodynamic therapy, − and drug delivery. ,, Specially, titanium dioxide (TiO 2 ) as the inorganic photosensitizer has been extensively used in PDT of cancer because TiO 2 can generate photoinduced hole–electron pairs that can react with oxygen and water to produce ROS to kill cancer cells under light irradiation . Traditional TiO 2 -based PDT mainly employed ultraviolet (UV) light as a light source.…”

Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Synthesis of Black Titanium Monoxide for Synergistic Tumor Phototherapy

Shu

Wang

Hai

et al. 2018

ACS Appl. Mater. Interfaces

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Black titanium oxide has attracted tremendous interest in tumor phototherapy via converting light energy to heat and reactive oxygen species (ROS). Nevertheless, current synthesis methods suffer from inert gas shielding, high costs, complicated procedures, and expensive facilities, which are fairly impractical for treatment application. Herein, we propose a one-step strategy for fast facile synthesis of black TiO nanoparticles via a microwave-assisted hydrothermal synthesis approach with Ti power, hydrochloric acid, and hydrofluoric acid without the requirement of an reducing agent and high-temperature calcination. The prepared black TiO nanoparticles with an average size of 52 nm exhibit strong absorbance from ultraviolet (UV) to near-infrared light region, favoring a single agent and single light-induced synergistic phototherapy of tumors. The black TiO nanoparticles shows an excellent performance in phototherapy with a photothermal conversion efficiency up to 50% and a prominent ROS generation under 808 nm laser irradiation. The toxicity and therapeutic effect in vitro and in vivo are investigated, and the results elucidate that black TiO nanoparticles possess good biocompatibility and remarkable synergistic tumor therapeutic efficacy. The proposed microwave-assisted method opens up a novel way for the synthesis of titanium-based material in a simple and fast manner, promoting their applications in the biomedical field.

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A multi-functional nanoplatform for tumor synergistic phototherapy

Cited by 16 publications

References 44 publications

Advances in Multiple Stimuli-Responsive Drug-Delivery Systems for Cancer Therapy

Advances in Multiple Stimuli-Responsive Drug-Delivery Systems for Cancer Therapy

Carbon Nanotube as a Tool for Fighting Cancer

Microwave-Assisted Synthesis of Black Titanium Monoxide for Synergistic Tumor Phototherapy

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