Influence of Ultraviolet Radiation on the Association between 25-Hydroxy Vitamin D Levels and Cardiovascular Risk Factors in Obesity

Prodam, Flavia; Zanetta, Sara; Ricotti, Roberta; Marolda, Agostina; Giglione, Enza; Monzani, Alice; Walker, Gillian E.; Rampone, Sara; Castagno, Matteo; Bellone, Simonetta; Petri, Antonella; Aimaretti, Gianluca; Bona, Gianni

doi:10.1016/j.jpeds.2015.12.032

Cited by 20 publications

(19 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, previous studies have shown an inverse correlation between 25(OH)D concentrations and LDL cholesterol with an independent effect of solar UV radiation (32 (39)(40)(41)(42)(43)(44)(45).…”

Section: Discussionmentioning

confidence: 94%

A randomized clinical trial in vitamin D–deficient adults comparing replenishment with oral vitamin D3 with narrow-band UV type B light: effects on cholesterol and the transcriptional profiles of skin and blood ,

Ponda

Liang

Kim

et al. 2017

The American Journal of Clinical Nutrition

View full text Add to dashboard Cite

Design: We performed a randomized clinical trial in vitamin Ddeficient adults and compared vitamin D replenishment between subjects who received oral vitamin D 3 (n = 60) and those who received narrow-band UVB exposure (n = 58) #6 mo. Results: There was no difference in the change from baseline LDLcholesterol concentrations between oral vitamin D 3 and UVB groups (difference in median of oral vitamin D 3 minus that of UVB: 1.5 mg/dL; 95% CI: 25.0, 7.0 mg/dL). There were also no differences within groups or between groups for changes in total or HDL cholesterol or triglycerides. Transcriptional profiling of skin and blood, however, revealed significant upregulation of immune pathway signaling with oral vitamin D 3 but significant downregulation with UVB. Conclusions: Correcting vitamin D deficiency with either oral vitamin D 3 or UVB does not improve the lipid profile. Beyond cholesterol, these 2 modalities of raising 25(OH)D have disparate effects on gene transcription. This trial was registered at clinicaltrials.gov as NCT01688102.

show abstract

Section: Discussionmentioning

confidence: 94%

A randomized clinical trial in vitamin D–deficient adults comparing replenishment with oral vitamin D3 with narrow-band UV type B light: effects on cholesterol and the transcriptional profiles of skin and blood ,

Ponda

Liang

Kim

et al. 2017

The American Journal of Clinical Nutrition

View full text Add to dashboard Cite

show abstract

“…In the literature, half-life of serum 25(OH)D has been reported to range from 2 to 3 weeks [ 43 ] to 2 months [ 44 ]. Also, the lag-time between a change in monthly UV dose and the corresponding change in 25(OH)D levels has been reported to range from 4 to 8 weeks [ 17 , 45 , 46 ].…”

Section: Methodsmentioning

confidence: 99%

“…In other countries in similar latitudes, such as Spain [ 21 – 23 ] and Italy [ 24 , 25 ] as well as in Europe, America and Australia more studies have been published in this area [ 26 , 27 ]. The investigation of the association between UVI and 25(OH)D was not done in older adults specifically [ 17 – 19 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Association between serum 25-hidroxyvitamin D concentrations and ultraviolet index in Portuguese older adults: a cross-sectional study

et al. 2017

View full text Add to dashboard Cite

BackgroundThe older population is a risk group for hypovitaminosis D. The Ultraviolet Index (UVI) can be an indicator of potential for cutaneous synthesis of vitamin D but physiological and other environmental factors also influence vitamin D synthesis and status. Knowledge about vitamin D status in Portuguese older adults is limited. This study aims to explore the association between Ultraviolet Index and serum 25-hidroxyvitamin D3 [25(OH)D] levels accounting for other potential influential factors.MethodsA cross-sectional study was conducted between December 2015 and June 2016, in 1497 Portuguese older adults (≥ 65 years) within Nutrition UP 65 project. For each participant, serum 25(OH)D was determined and the mean UVI (mUVI) in the respective residence district was calculated for the previous 30 days. Stepwise linear regression analyses were conducted for the following periods of blood collection: between December and June, December and March and April and June. Standardized regression coefficients (Sβ) and 95% confidence intervals were calculated.ResultsThe median 25(OH)D concentration was 35.9 nmol/L. The UVI was independently and positively associated with 25(OH)D in the models for December–June (Sβ = 0.244, 95% CI: 0.198; 0.291, P < 0.001) and April–June (Sβ = 0.295, 95% CI: 0.299; 0.362, P < 0.001) and independently and negatively associated in December–March period (Sβ = −0.149, 95% CI: -0.211; −0.087, P < 0.001).ConclusionsIn this sample with high vitamin D deficiency frequency, the UVI was a predictor of 25(OH)D levels but the direction of the association varied according to the blood collection period. Our results suggest that accounting for the time of year in future research regarding vitamin status and related public health recommendations may be relevant.Electronic supplementary materialThe online version of this article (10.1186/s12877-017-0644-8) contains supplementary material, which is available to authorized users.

show abstract

“…Although without significance, our results showed a positive correlation between VD and HDL-c levels. Sriram et al [34] and Prodam et al [35] showed that VD levels are negatively correlated with total cholesterol, Contradicting recent studies that have shown that supplementation with VD may improve glycemia and lipid profile in children with deficiency of this vitamin [36] [37] [38], Jamka et al [39] and Jamka et al [40] performed meta-analysis that showed no correlation between VD and glucose and lipid levels.…”

Section: Discussionmentioning

confidence: 99%

Association of Vitamin D Levels with the Metabolic Profile and Sexual Maturation Stage of Adolescents

Haber¹,

Quesada²,

Lopes³

et al. 2018

JDM

View full text Add to dashboard Cite

The deficiency of Vitamin D (VD) is widely prevalent worldwide in adults, but many studies show that this deficiency also affects adolescents and may be considered a global public health problem. The VD levels are particularly significant in adolescents since it influences several aspects of growth, development, and puberty. During this phase of life, both girls and boys develop reproductive aspects, and secondary sexual characteristics and the adequate nutritional status appear to be the prerequisite for normal pubertal development. Due to the importance of VD in adolescents, the objective of this study was to investigate the association of the levels of this vitamin with glycemic, lipid, and anthropometric profile and sexual maturation stages of adolescents. Anthropometric (weight and height) and biochemical (fasting glycemia, total cholesterol, HDL-c, LDL-c, and triglycerides) data and VD levels were collected in 67 adolescents. 66% of the adolescents showed VD sufficiency, 28% insufficiency, and 6% showed the deficiency. There was a significant difference in VD levels between the stages of sexual maturation for boys and girls. Overweight patients had lower serum VD levels. The correlation analysis indicated a positive correlation between VD and fasting glycemia and HDL-c, but with no significant difference. A negative correlation was observed between VD and cholesterol, LDL-c and triglycerides, but also with no significant difference. Once VD is crucial for bone health, and as it seems it is necessary to the homeostasis of glycemia, lipids, and body weight, we suggest that more studies should be conducted to confirm the precise role of this vitamin in the promotion and maintenance of health in this population. How to cite this paper: Haber, J.

show abstract

Influence of Ultraviolet Radiation on the Association between 25-Hydroxy Vitamin D Levels and Cardiovascular Risk Factors in Obesity

Cited by 20 publications

References 25 publications

A randomized clinical trial in vitamin D–deficient adults comparing replenishment with oral vitamin D3 with narrow-band UV type B light: effects on cholesterol and the transcriptional profiles of skin and blood ,

A randomized clinical trial in vitamin D–deficient adults comparing replenishment with oral vitamin D3 with narrow-band UV type B light: effects on cholesterol and the transcriptional profiles of skin and blood ,

Association between serum 25-hidroxyvitamin D concentrations and ultraviolet index in Portuguese older adults: a cross-sectional study

Association of Vitamin D Levels with the Metabolic Profile and Sexual Maturation Stage of Adolescents

Contact Info

Product

Resources

About