Advanced Small Animal Conformal Radiation Therapy Device

Sharma, Sunil; Narayanasamy, G.; Przybyla, Beata; Webber, Jessica; Boerma, Marjan; Clarkson, Richard W. E.; Moros, Eduardo G.; Corry, Peter M.; Griffin, Robert J.

doi:10.1177/1533034615626011

Cited by 26 publications

(22 citation statements)

References 28 publications

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“…Devices for precise, regional delivery of radiation [206] have enabled comparison of irradiated vs. untreated lung parenchyma. HP 129 Xe has shown promise with respect to the lung inflammation and fibrotic processes underlying RILI because of its solubility in tissues and blood.…”

Section: Applications Of Hyperpolarized Gas Mri To Pre-clinical Anmentioning

confidence: 99%

Magnetic resonance imaging with hyperpolarized agents: methods and applications

et al. 2017

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In the past decade, hyperpolarized (HP) contrast agents have been under active development for MRI applications to address the twin challenges of functional and quantitative imaging. Both HP helium (3He) and xenon (129Xe) gases have reached the stage where they are under study in clinical research. HP 129Xe, in particular, is poised for larger scale clinical research to investigate asthma, chronic obstructive pulmonary disease, and fibrotic lung diseases. With advances in polarizer technology and unique capabilities for imaging of 129Xe gas exchange into lung tissue and blood, HP 129Xe MRI is attracting new attention. In parallel, HP 13C and 15N MRI methods have steadily advanced in a wide range of pre-clinical research applications for imaging metabolism in various cancers and cardiac disease. The HP [1-13C] pyruvate MRI technique, in particular, has undergone phase I trials in prostate cancer and is poised for investigational new drug trials at multiple institutions in cancer and cardiac applications. This review treats the methodology behind both HP gases and HP 13C and 15N liquid state agents. Gas and liquid phase HP agents share similar technologies for achieving non-equilibrium polarization outside the field of the MRI scanner, strategies for image data acquisition, and translational challenges in moving from pre-clinical to clinical research. To cover the wide array of methods and applications, this review is organized by numerical section into 1) a brief introduction, 2) the physical and biological properties of the most common polarized agents with a brief summary of applications and methods of polarization, 3) methods for image acquisition and reconstruction specific to improving data acquisition efficiency for HP MRI, 4) the main physical properties that enable unique measures of physiology or metabolic pathways, followed by a more detailed review of the literature describing the use of HP agents to study 5) metabolic pathways in cancer and cardiac disease and 6) lung function in both pre-clinical and clinical research studies, 7) some future directions and challenges, and 8) an overall summary.

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Section: Applications Of Hyperpolarized Gas Mri To Pre-clinical Anmentioning

confidence: 99%

Magnetic resonance imaging with hyperpolarized agents: methods and applications

et al. 2017

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“…Radiotherapy studies on various small animal cancer models mimicking human treatment are useful to test potential therapeutics . Several small animal irradiators based on x‐ray computed tomography (CT) guidance have been developed, including our recently developed image‐guided SMall Animal Arc Radiation Treatment system (iSMAART) . The performance of the iSMAART system has been thoroughly evaluated, including CT imaging quality, image guidance capability, animal positioning stability, radiation targeting precision, and stereotactic radiation beam delivery …”

Section: Introductionmentioning

confidence: 99%

“…1 Several small animal irradiators based on x-ray computed tomography (CT) guidance have been developed, including our recently developed image-guided SMall Animal Arc Radiation Treatment system (iSMAART). [2][3][4][5] The performance of the iSMAART system has been thoroughly evaluated, including CT imaging quality, image guidance capability, animal positioning stability, radiation targeting precision, and stereotactic radiation beam delivery. 5 Although CT provides excellent bone to soft tissue contrast and is indispensable for tumor irradiation guidance, differentiating tumor from its surrounding soft tissues remains challenging.…”

Section: Introductionmentioning

confidence: 99%

Optical molecular imaging‐guided radiation therapy part 2: Integrated x‐ray and fluorescence molecular tomography

et al. 2017

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Purpose: Differentiating tumor from its surrounding soft tissues is challenging for x-ray computed tomography (CT). Fluorescence molecular tomography (FMT) can directly localize the internal tumors targeted with specific fluorescent probes. A FMT system was developed and integrated onto a CT-guided irradiator to improve tumor localization for image-guided radiation. Methods: The FMT system was aligned orthogonal to the cone-beam CT onboard our previously developed image-guided small animal arc radiation treatment system (iSMAART). Through rigorous physical registration, the onboard CT provides accurate surface contour which is used to generate three-dimensional mesh for FMT reconstruction. During FMT experiments, a point laser source perpendicular to the rotating axis was used to excite the internal fluorophores. The normalized optical images from multiple projection angles were adopted for tomographic reconstruction. To investigate the accuracy of the FMT in locating the tumor and recovering its volume, in vivo experiments were conducted on two breast cancer models: MDA-MB-231 cancer xenograft on nude mice and 4T1 cancer xenograft on white mice. Both cancer cell lines overexpress the epidermal growth factor receptor (EGFR). A novel fluorescent poly(lactic-co-glycolic) acid (PLGA) nanoparticle conjugated with anti-EGFR was intravenously injected to specifically target the breast cancer cells. Another ex vivo experiment on a mouse bearing a surgically implanted Indocyanine Green-containing glass tube was conducted, to additionally validate the precision of FMT-guided radiation therapy. Results: The FMT can accurately localize the single-nodule breast tumors actively targeted with fluorescent nanoparticles with localization error < 0.5 mm calculated between the centers of mass of tumors in FMT and CT. The reconstructed tumor volume in FMT was significantly correlated with that in the iodinated contrast-enhanced CT (R 2 = 0.94, P < 0.001). The FMT was able to guide focal radiation delivery with submillimeter accuracy. Conclusion: Using the tumor-targeting fluorescent probes, the iSMAART with onboard FMT system can accurately differentiate tumors from their surrounding soft tissue, guide precise focal radiation delivery, and potentially assess tumor response in cancer research.

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“…Image‐guided small animal radiation technology, allowing accurate focal irradiation to biological targets, has achieved significant advances in recent years . Several small animal irradiators utilizing x‐ray computed tomography (CT) guidance have been developed, including the image‐guided SMall Animal Arc Radiation Treatment system (iSMAART) developed by our group . The performance of the iSMAART system has been thoroughly evaluated in terms of image guidance and radiation targeting …”

Section: Introductionmentioning

confidence: 99%

“…1 Several small animal irradiators utilizing x-ray computed tomography (CT) guidance have been developed, including the image-guided SMall Animal Arc Radiation Treatment system (iSMAART) developed by our group. [2][3][4][5] The performance of the iSMAART system has been thoroughly evaluated in terms of image guidance and radiation targeting. 5 Although CT is indispensable for tumor radiation guidance, it faces challenges in differentiating tumors from surrounding soft tissues, because the tumor and soft tissue have similar x-ray attenuation coefficients.…”

Section: Introductionmentioning

confidence: 99%