Clinicopathological characteristics of young patients with sporadic colorectal cancer

Murata, Asuka; Akiyoshi, Takashi; Ueno, Masashi; Fukunaga, Yosuke; Nagayama, Satoshi; Fujimoto, Yoshiya; Konishi, Tsuyoshi; Nagasaki, Toshiya; Nagata, Jun; Ohno, Riki; Arai, Masami; Yamaguchi, Toshiharu

doi:10.1007/s00595-015-1298-9

Cited by 15 publications

(16 citation statements)

References 35 publications

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“…Studies on young CRC patients have used different criteria due to the ambiguous definition of “young” age. Some studies considered younger patients as those aged less than the screening age for CRC based on treatment guidelines [7,17], while others evaluated patients 10 years younger than screening age for CRC [15,18,19]. Thus, there is a need for a consensus about what age can be defined as young in CRC patients.…”

Section: Discussionmentioning

confidence: 99%

Differences in biological behaviors between young and elderly patients with colorectal cancer

Cheong

Kim

et al. 2019

PLoS ONE

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Background We investigated the differences in biological behaviors of sporadic colorectal cancer (CRC) between young and elderly patients. CRC is a common cancer, with a mean age at onset of > 65 years. However, recent reports indicate increasing rates in younger populations. The biological behaviors of sporadic CRC in elderly patients could differ from those in young patients. Methods Between September 2007 and August 2012, we selected 723 CRC patients from our institution. The patients were divided into Group Y (n = 127, aged ≤50 years) and Group O (n = 596, aged >50 years). The clinicopathologic and oncologic outcomes in the two groups were compared. Results Group Y tumors were characterized by higher incidences of mucin production (13.4% vs. 6.7%; P = 0.017), high microsatellite instability (MSI-H) (19.8% vs. 5.2%; P < 0.001), and N2 stage (32.3% vs. 22.1%; P = 0.020) than those in Group O. The recurrence rates were similar in both groups (14.9% vs. 17.3%; P = 0.665). The 5-year overall survival and disease-free survival did not differ. Multivariate analysis indicated that cellular differentiation and pathologic stage were significant prognostic factors for 5-year overall survival. Conclusion Although age was not a prognostic factor for overall survival and young patients did not show a worse prognosis, there were differences in mucin production, MSI-H, and N2 stage between the two groups. Further studies are needed to clarify the clinical and biological characteristics of CRC, improve its treatment strategies, and promote better outcomes in young patients.

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Section: Discussionmentioning

confidence: 99%

Differences in biological behaviors between young and elderly patients with colorectal cancer

Cheong

Kim

et al. 2019

PLoS ONE

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“…We systematically retrieved 37 articles describing the prognosis of EO‐CRC compared with older patients (Abdelsattar et al ., ; Blanke et al ., ; Boyce et al ., ; Chandrasinghe et al ., ; Chou et al ., , ; Damodaran and Seshadri, ; Fu et al ., ; Fu et al ., ; Haleshappa et al ., ; Hawk et al ., ; Hubbard et al ., ; Josifovski et al ., ; Khan et al ., ; Kim et al ., ; Kneuertz et al ., ; Kolarich et al ., ; Li et al ., ; Lieu et al ., ; Manjelievskaia et al ., ; McMillan and McArdle, ; Murata et al ., ; O'Connell et al ., ; Orsini et al ., ; Pokharkar et al ., ; Quah et al ., ; Rho et al ., ; Rodriguez et al ., ; Shen et al ., ; Shida et al ., ; Sultan et al ., ; Vatandoust et al ., ; Wang et al ., ,; Yang et al ., ; You et al ., ; Zhao et al ., ). EO‐CRC survival data are conflicting.…”

Section: Methodsmentioning

confidence: 99%

Early‐onset colorectal cancer in young individuals

et al. 2018

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Treatment of young adults with colorectal cancer (CRC) represents an unmet clinical need, especially as diagnosis in this population might lead to the greatest loss of years of life. Since 1994, CRC incidence in individuals younger than 50 years has been increasing by 2% per year. The surge in CRC incidence in young adults is particularly alarming as the overall CRC frequency has been decreasing. Early‐onset CRC are characterized by a more advanced stage at diagnosis, poorer cell differentiation, higher prevalence of signet ring cell histology, and left colon‐sided location of the primary tumor. Among EO‐CRC, approximately 30% of patients are affected by tumors harboring mutations causing hereditary cancer predisposing syndromes, and 20% have familial CRC. Most notably, the remaining 50% of EO‐CRC patients have neither hereditary syndromes nor familial CRC, thus representing a formidable challenge for research. In this review article we summarize epidemiology, clinical and molecular features, heredity and outcome of treatments of EO‐CRC, and provide considerations for future perspectives.

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“…1 Thus, in order to better estimate an individual patient's chances of harboring clinically silent micrometastatic disease and to assess recurrence risk, the integration of reliable prognostic information provided by genomic testing and clinicopathological factors is critical for bedside tangible outcomes. 9,25 However, it is highly challenging task particularly for cancers with higher rate of worldwide occurrence and those characterized by various histotypes such as CRC. 3,4 These histotypes demonstrate high level of variability in cancer onset and progression, metastatic pattern, chemotherapeutic response, resistance development, and clinical outcome.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of Osteopontin (SPP1) in colorectal carcinoma requires a personalized molecular approach

et al. 2019

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Stratification of colorectal cancer for better management and tangible clinical outcomes is lacking in clinical practice. To reach this goal, the identification of reliable biomarker(s) is a prerequisite to deliver personalized colorectal cancer theranostics. Osteopontin (SPP1) is a key extracellular matrix protein involved in several pathophysiological processes including cancer progression and metastasis. However, the exact molecular mechanisms regulating its expression, localization, and molecular functions in cancer are still poorly understood. This study was designed to investigate the SPP1 expression profiles in Saudi colorectal cancer patients, and to assess its prognostic value. Hundred thirty-four (134) archival paraffin blocks of colorectal cancer were collected from King Abdulaziz University Hospital, Saudi Arabia. Tissue microarrays were constructed, and automated immunohistochemistry was performed to evaluate SPP1 protein expression patterns in colorectal cancer. About 20% and 23% of our colorectal cancer samples showed high SPP1 cytoplasmic and nuclear expression patterns, respectively. Cytoplasmic SPP1 did not correlate with age, gender, tumor size, and location. However, significant correlations were observed with tumor grade ( p = 0.008), tumor invasion ( p = 0.01), and distant metastasis ( p = 0.04). Kaplan–Meier survival analysis showed a significantly lower recurrence rate in patients with higher SPP1 cytoplasmic expression ( p = 0.05). At multivariate analysis, high SPP1 cytoplasmic expression was an independent favorable prognostic marker ( p = 0.02). However, nuclear SPP1 expression did not show any prognostic value ( p = 0.712). Our results showed a particular SPP1 prognostic relevance that is not in line with most colorectal cancer previous studies that may be attributed to the molecular pathophysiology of our colorectal cancer cohort. Saudi Arabia has both specific genomic makeup and particular environment that could lead to distinctive molecular roots of cancer. SPP1 has several isoforms, tissue localizations and molecular functions, signaling pathways, and downstream molecular functions. Therefore, a more individualized approach for CRC studies and particularly SPP1 prognosis outcomes’ assessment is highly recommended toward precision oncology.

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Clinicopathological characteristics of young patients with sporadic colorectal cancer

Abstract: Young Japanese patients with sporadic CRC have unique characteristics such as a high incidence of rectal cancer and similar pathological features; however, they appear to have comparable survival to older patients.

Cited by 15 publications

References 35 publications

Differences in biological behaviors between young and elderly patients with colorectal cancer

Differences in biological behaviors between young and elderly patients with colorectal cancer

Early‐onset colorectal cancer in young individuals

Prognostic value of Osteopontin (SPP1) in colorectal carcinoma requires a personalized molecular approach

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