2016
DOI: 10.1631/jzus.b1500065
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左卡尼汀(而非辅酶q10)提高阿托伐他汀在切除卵巢的老鼠的抗骨质疏松作用

Abstract: Abstract:Objective: Statins' therapy in osteoporosis can aggravate muscle damage. This study was designed to assess which agent, L-carnitine or coenzyme Q10, could enhance the anti-osteoporotic effect of atorvastatin while antagonizing myopathy in ovariectomized rats. Methods: Forty-eight female Sprague Dawley rats were used; forty rats were ovariectomized while eight were sham-operated. Eight weeks post-ovariectomy, rats were divided into ovariectomized-untreated group and four ovariectomized-treated groups (… Show more

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Cited by 4 publications
(2 citation statements)
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References 62 publications
(68 reference statements)
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“…The carnitine needed for this transport is easily obtained from dietary sources or by de novo synthesis; however it is interesting to note that carnitine levels often decrease with age. As such, carnitine supplementation in an aging, OVX rat model of postmenopausal osteoporosis was able to increase bone mineral density (BMD) (Murad, 2016). While these data are compelling, recent data specifically targeting carnitine palmitoyltransferase II (CPTII), the obligate enzyme required to facilitate fatty acid entry in to the mitochondria, in osteoblasts, results in compromised bone acquisition in female mice (Kim et al, 2017b).…”
Section: Lipid Utilization For Mitochondrial Respirationmentioning
confidence: 99%
“…The carnitine needed for this transport is easily obtained from dietary sources or by de novo synthesis; however it is interesting to note that carnitine levels often decrease with age. As such, carnitine supplementation in an aging, OVX rat model of postmenopausal osteoporosis was able to increase bone mineral density (BMD) (Murad, 2016). While these data are compelling, recent data specifically targeting carnitine palmitoyltransferase II (CPTII), the obligate enzyme required to facilitate fatty acid entry in to the mitochondria, in osteoblasts, results in compromised bone acquisition in female mice (Kim et al, 2017b).…”
Section: Lipid Utilization For Mitochondrial Respirationmentioning
confidence: 99%
“…Murad et al, [81] mentioned that L-Carnitine occupy a vital role in the mitochondrial transport and oxidation of fatty acids. Shehata et al, [82] stated that L-carnitine defend against mitochondrial malfunctions accompanying oxidative strain caused by many factors such as aging, ischemia reperfusion, inflammation, degenerative diseases, carcinogenesis and drug toxicity, in vivo or in vitro.…”
Section: Discussionmentioning
confidence: 99%