Efficacy of feed additives against Campylobacter in live broilers during the entire rearing period: Part B

Gracia, Marta; Millán, Carlos; Sánchez, J.; Guyard‐Nicodème, Muriel; Mayot, J.; Carre, Y.; Csorbai, A.; Chemaly, Marianne; Medel, P.

doi:10.3382/ps/pev346

Cited by 44 publications

(42 citation statements)

References 26 publications

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“…Although they showed no significant impact on their own, prebiotics did significantly decrease the amount of Campylobacter when used in combination with three probiotic species (Arsi et al, 2015a). Similar studies supported these results where Campylobacter loads were reduced in the presence of a combination of prebiotics and probiotics (Peng et al, 2015; Gracia et al, 2016; Guyard-Nicodeme et al, 2016). …”

Section: Probiotics As a Treatment For Campylobacter Colonizationsupporting

confidence: 75%

Current and Potential Treatments for Reducing Campylobacter Colonization in Animal Hosts and Disease in Humans

2017

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Campylobacter jejuni is the leading cause of bacteria-derived gastroenteritis worldwide. In the developed world, Campylobacter is usually acquired by consuming under-cooked poultry, while in the developing world it is often obtained through drinking contaminated water. Once consumed, the bacteria adhere to the intestinal epithelium or mucus layer, causing toxin-mediated inhibition of fluid reabsorption from the intestine and invasion-induced inflammation and diarrhea. Traditionally, severe or prolonged cases of campylobacteriosis have been treated with antibiotics; however, overuse of these antibiotics has led to the emergence of antibiotic-resistant strains. As the incidence of antibiotic resistance, emergence of post-infectious diseases, and economic burden associated with Campylobacter increases, it is becoming urgent that novel treatments are developed to reduce Campylobacter numbers in commercial poultry and campylobacteriosis in humans. The purpose of this review is to provide the current status of present and proposed treatments to combat Campylobacter infection in humans and colonization in animal reservoirs. These treatments include anti-Campylobacter compounds, probiotics, bacteriophage, vaccines, and anti-Campylobacter bacteriocins, all of which may be successful at reducing the incidence of campylobacteriosis in humans and/or colonization loads in poultry. In addition to reviewing treatments, we will also address several proposed targets that may be used in future development of novel anti-Campylobacter treatments.

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Section: Probiotics As a Treatment For Campylobacter Colonizationsupporting

confidence: 75%

Current and Potential Treatments for Reducing Campylobacter Colonization in Animal Hosts and Disease in Humans

2017

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“…None of the three treatments (T3, T4, and T7) used from day 1 was able to prevent Campylobacter colonization detected at day 42. Similar results were observed in previous works testing several feed additives in experimental facilities with artificial Campylobacter contamination on fast-growing broilers (Gracia et al, 2016; Guyard-Nicodeme et al, 2016; Saint-Cyr et al, 2016b). Moreover, no treatment using single product (T2, T3, T4, T5, and T7) led to a significant reduction of Campylobacter in caeca, compared to the control group at the end of the rearing period.…”

Section: Discussionsupporting

confidence: 91%

“…Reduction in the caeca was low, as less than 1 log 10 CFU/g (0.82 ± 0.25 log10 CFU/g) was observed. Several previous studies presented results of feed or water additives leading to a reduction of Campylobacter colonization higher than 2 log 10 CFU/g but they were performed in experimental facilities with an artificial Campylobacter challenge (Nishiyama et al, 2014; Arsi et al, 2015; Gracia et al, 2016; Guyard-Nicodeme et al, 2016; Saint-Cyr et al, 2016b). However, these controlled conditions cannot reflect the field conditions, especially free-range conditions exposed to multiple sources of contaminations and contaminated with genetically diverse Campylobacter isolates (Rivoal et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…They give some promising results in experimental trials leading to at least 2 log 10 CFU/g reduction or more in Campylobacter colonization for some of them (Skanseng et al, 2010; Ghareeb et al, 2012; Guyard-Nicodeme et al, 2016; Saint-Cyr et al, 2016b). In these studies testing feed additives, trials were generally performed using conventional production conditions: indoor rearing, broiler breeds, whole rearing (Hilmarsson et al, 2006; Thibodeau et al, 2015; Gracia et al, 2016; Guyard-Nicodeme et al, 2016), or shorter periods (Solis de Los Santos et al, 2008; Skanseng et al, 2010; Ghareeb et al, 2012). However, there is an increasing consumer interest in free-range poultry.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Feed Additives on Productivity and Campylobacter spp. Loads in Broilers Reared under Free Range Conditions

et al. 2017

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The poultry reservoir, especially broiler meat, is generally recognized as one of the most-important sources for human Campylobacteriosis. The measures to control Campylobacter targeted essentially the primary production level. The aim of this work was to evaluate the effectiveness of different treatments against natural Campylobacter colonization in a French experimental farm of free-range broilers during the whole rearing period. Five commercial products and a combination of two of them were tested and all the products were added to feed or to water at the dose recommended by the suppliers. Campylobacter loads in caeca and on carcasses of broilers at the slaughter were determined by culture methods. Natural contamination of the flock occurred at the end of the indoor rearing period between day 35 and day 42. At day 42, the multispecies probiotic added to the feed reduced the contamination of 0.55 log10 CFU/g (p = 0.02) but was not significant (p > 0.05) at the end of rearing at day 78. However, another treatment, a combination of a cation exchange clay-based product in feed and an organic acid mixture (formic acid, sodium formate, lactic acid, propionic acid) in water, led to a slight but significant reduction of 0.82 ± 0.25 log10 CFU/g (p = 0.02) compared to the control group at day 78. Testing this combination in field conditions in several flocks is needed to determine if it is biologically relevant and if it could be a valuable measure to reduce Campylobacter in broiler flocks.

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“…Using two groups of around 40 broilers kept in three‐bird cages, Gracia et al. () examined the inclusion in drinking water of blends of monoglycerides of three‐ to 12‐carbon acids, with or without additional free organic acid mixes. Water was treated throughout a 6‐week rearing period, with oral C. jejuni inoculation (10 4 cfu) at 14 days of age and periodic post mortem sampling of 10 to 12 birds.…”

Section: Interventions Complementary To Biosecurity and Hygienementioning

confidence: 99%

Field Interventions Against Colonization of Broilers by Campylobacter

Wales

Vidal

Davies

et al. 2018

Comp Rev Food Sci Food Safe

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Poultry accounts for a high proportion of human campylobacteriosis cases, and the problem of Campylobacter colonization of broiler flocks has proven to be intractable. Owing to their broad host range and genetic instability, Campylobacter organisms are ubiquitous and adaptable in the broiler farm environment, colonizing birds heavily and spreading rapidly after introduction into a flock. This review examines strategies to prevent or suppress such colonization, with a heavy emphasis on field investigations. Attempts to exclude Campylobacter via enhanced biosecurity and hygiene measures have met with mixed success. Reasons for this are becoming better understood as investigations focus on houses, ventilation, biosecurity practices, external operators, and compliance, among other factors. It is evident that piecemeal approaches are likely to fail. Complementary measures include feed and drinking water treatments applied in either preventive or suppressive modes using agents including organic acids and their derivatives, also litter treatments, probiotics, prebiotics, and alterations to diet. Some treatments aim to reduce the number of Campylobacter organisms entering abattoirs by suppressing intestinal colonization just before slaughter; these include acid water treatment or administration of bacteriophages or bacteriocins. Experimental vaccines historically have had little success, but some recent subunit vaccines show promise. Overall, there is wide variation in the control achieved, and consistency and harmonization of trials is needed to enable robust evaluation. There is also some potential to breed for resistance to Campylobacter. Good and consistent control of flock colonization by Campylobacter may require an as‐yet undetermined combination of excellent biosecurity plus complementary measures.

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Efficacy of feed additives against Campylobacter in live broilers during the entire rearing period: Part B

Cited by 44 publications

References 26 publications

Current and Potential Treatments for Reducing Campylobacter Colonization in Animal Hosts and Disease in Humans

Current and Potential Treatments for Reducing Campylobacter Colonization in Animal Hosts and Disease in Humans

Effect of Feed Additives on Productivity and Campylobacter spp. Loads in Broilers Reared under Free Range Conditions

Field Interventions Against Colonization of Broilers by Campylobacter

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